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Pleconaril

Pleconaril (Picovir) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and…

History, Resistance & Mechanism of action

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Key facts & relationships

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3D model (JSmol)
Interactive image
ATC code
J05AX06 (WHO)
Bioavailability
70% (oral)
CAS Number
153168-05-9 N
ChEMBL
ChEMBL29609 Y
ChemSpider
1621 Y

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Overview

History

Mechanism of action

Clinical trials

Resistance

Side effects

Advanced semantic analysis

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Map overview Semantic statistics

Pleconaril

Nodes34
Edges33
Triples79
Avg. degree1.94
Density0.058824
Components1

How this topic connects Entity context

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Pleconaril

Top relations

related to Mechanism of action · 18
Pleconaril → Amino, CVB3, Drugs, HRVs, Human, In, In Coxsackievirus, Proteins VP1, RNA, The, Through, Tyr152, Val191, VP1, VP1-VP4, VP2, VP3, VP4
related to Resistance · 14
Pleconaril → Amino, Coxsackievirus B3, CVB3, HRV, Ile1092, In, Leu, Leu1092, Met, Methyl, Nancy, The, The Ile, VP1
related to history · 11
Pleconaril → Drug Administration, FDA, However, II, New Drug Application, Sanofi-Aventis, Schering-Plough, The, The Phase II, United States Food, ViroPharma
related to Clinical trials · 9
Pleconaril → Another, Canada, Of, Participants, Resistance, The, To, United States, Virus
has effect · 8
Pleconaril → Drug Administration, Food, In, Menstrual, Other, P-450, Some, The
3D model (JSmol) · 1
Pleconaril → Interactive image
ATC code · 1
Pleconaril → J05AX06 (WHO)
Bioavailability · 1
Pleconaril → 70% (oral)
CAS Number · 1
Pleconaril → 153168-05-9 N
ChEMBL · 1
Pleconaril → ChEMBL29609 Y

Important terminology Word statistics

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Important terminology

pocket drug resistance trial amino two virus vp1 hydrophobic placebo participants symptoms patients shown clinical enterovirus binding asthma intranasal acid

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pleconaril3D model (JSmol)Interactive image1.00infobox
PleconarilATC codeJ05AX06 (WHO)1.00infobox
PleconarilBioavailability70% (oral)1.00infobox
PleconarilCAS Number153168-05-9 N1.00infobox
PleconarilChEMBLChEMBL29609 Y1.00infobox
PleconarilChemSpider1621 Y1.00infobox
PleconarilCompTox Dashboard (EPA)DTXSID80576491.00infobox
PleconarilDrugBankDB05105 N1.00infobox
PleconarilECHA InfoCard100.208.9471.00infobox
PleconarilExcretion<1% excreted unchanged in urine1.00infobox
PleconarilFormulaC18H18F3N3O31.00infobox
PleconarilLegal status?1.00infobox
PleconarilMetabolismHepatic1.00infobox
PleconarilMolar mass381.355 g·mol−11.00infobox
PleconarilPDB ligandW11 (PDBe, RCSB PDB)1.00infobox
PleconarilProtein binding>99%1.00infobox
PleconarilPubChem CID16841.00infobox
PleconarilRoutes of administrationOral, intranasal1.00infobox
PleconarilUNII9H4570Q89D1.00infobox

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