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Pleconaril: History, Resistance & Mechanism of action

Pleconaril (Picovir) is an antiviral drug that was being developed by Schering-Plough for prevention of asthma exacerbations and common cold symptoms in patients exposed to picornavirus respiratory infections. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and…

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Pleconaril topic overview

The analysis highlights History, Resistance and Mechanism of action as prominent areas in the source structure around Pleconaril.

Related topics: 27
Source areas: 6
Connected nodes: 33
Extracted relationships: 79
Concept neighborhoods: 18
Bridge connections: 33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics

History · 5 topics

Resistance · 5 topics

Mechanism of action · 4 topics

Clinical trials · 3 topics

Side effects · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
ATC code: J05AX06 (WHO)
Bioavailability: 70% (oral)
CAS Number: 153168-05-9 N
ChEMBL: ChEMBL29609 Y
ChemSpider: 1621 Y

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Mechanism of action

RNA
Tyr Tyrosine
Val Valine
Coxsackievirus

Clinical trials

Phase II Phases of clinical research
Intranasal
PCR Polymerase chain reaction

Resistance

Phenylalanine
Leu Leucine
Coxsackievirus B3 (CVB3) Coxsackie B virus
Ile Isoleucine
Met Methionine

Side effects

Cytochrome P-450 3A enzymes CYP3A

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pleconaril connects Entity context

The extracted context around Pleconaril shows recurring relationship patterns in the source. For example, Pleconaril → Amino, CVB3, Drugs, HRVs, Human, In, In Coxsackievirus, Proteins VP1, RNA, The, Through, Tyr152, Val191, VP1, VP1-VP4, VP2, VP3, VP4 Another extracted example is Pleconaril → Amino, Coxsackievirus B3, CVB3, HRV, Ile1092, In, Leu, Leu1092, Met, Methyl, Nancy, The, The Ile, VP1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pleconaril

Top relations

related to Mechanism of action · 18

Pleconaril → Amino, CVB3, Drugs, HRVs, Human, In, In Coxsackievirus, Proteins VP1, RNA, The, Through, Tyr152, Val191, VP1, VP1-VP4, VP2, VP3, VP4

related to Resistance · 14

Pleconaril → Amino, Coxsackievirus B3, CVB3, HRV, Ile1092, In, Leu, Leu1092, Met, Methyl, Nancy, The, The Ile, VP1

related to history · 11

Pleconaril → Drug Administration, FDA, However, II, New Drug Application, Sanofi-Aventis, Schering-Plough, The, The Phase II, United States Food, ViroPharma

related to Clinical trials · 9

Pleconaril → Another, Canada, Of, Participants, Resistance, The, To, United States, Virus

has effect · 8

Pleconaril → Drug Administration, Food, In, Menstrual, Other, P-450, Some, The

3D model (JSmol) · 1

Pleconaril → Interactive image

ATC code · 1

Pleconaril → J05AX06 (WHO)

Bioavailability · 1

Pleconaril → 70% (oral)

CAS Number · 1

Pleconaril → 153168-05-9 N

ChEMBL · 1

Pleconaril → ChEMBL29609 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pocket drug resistance trial amino two virus vp1 hydrophobic placebo participants symptoms patients shown clinical enterovirus binding asthma intranasal acid

Pleconaril relationships Subject–Predicate–Object triples

TTTA extracted 79 structured relationships around Pleconaril. Examples in this analysis include Pleconaril → 3D model (JSmol) → Interactive image and Pleconaril → ATC code → J05AX06 (WHO). The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Pleconaril	3D model (JSmol)	Interactive image	1.00	infobox
Pleconaril	ATC code	J05AX06 (WHO)	1.00	infobox
Pleconaril	Bioavailability	70% (oral)	1.00	infobox
Pleconaril	CAS Number	153168-05-9 N	1.00	infobox
Pleconaril	ChEMBL	ChEMBL29609 Y	1.00	infobox
Pleconaril	ChemSpider	1621 Y	1.00	infobox
Pleconaril	CompTox Dashboard (EPA)	DTXSID8057649	1.00	infobox
Pleconaril	DrugBank	DB05105 N	1.00	infobox
Pleconaril	ECHA InfoCard	100.208.947	1.00	infobox
Pleconaril	Excretion	<1% excreted unchanged in urine	1.00	infobox
Pleconaril	Formula	C18H18F3N3O3	1.00	infobox
Pleconaril	Legal status	?	1.00	infobox
Pleconaril	Metabolism	Hepatic	1.00	infobox
Pleconaril	Molar mass	381.355 g·mol−1	1.00	infobox
Pleconaril	PDB ligand	W11 (PDBe, RCSB PDB)	1.00	infobox
Pleconaril	Protein binding	>99%	1.00	infobox
Pleconaril	PubChem CID	1684	1.00	infobox
Pleconaril	Routes of administration	Oral, intranasal	1.00	infobox
Pleconaril	UNII	9H4570Q89D	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pleconaril bring nearby vocabulary together. In this analysis, examples include Resistance, Virus and Group. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Pleconaril
- Resistance
- Virus
- Group
- Placebo
- Asthma
- Cold
- Intranasal
- Oral
- Treatment
- Patients
- Symptoms
- Hydrophobic
pleconaril
- Resistance
- Virus
- Group
- Placebo
- Asthma
- Cold
- Intranasal
- Oral
- Treatment
- Patients
- Symptoms
- Hydrophobic
food and drug administration
- Effects
- Side
- Administration
- Developed
- Drug
- Intranasal
- Oral
- Viropharma
- Clinical
- Schering-plough
- Asthma
- Cold
antiviral drug
- Administration
- Developed
- Schering-plough
- Asthma
- Cold
- Common
- Effects
- Side
- Viropharma
- Binding
- Clinical
- Patients
new drug application
- Administration
- Developed
- Schering-plough
- Asthma
- Cold
- Common
- Effects
- Side
- Viropharma
- Binding
- Clinical
- Patients
asthma
- Cold
- Common
- Ii
- Intranasal
- Phase
- Symptoms
- Rhinovirus
- Schering-plough
- Developed
- Treatment
- Clinical
- Patients
clinical trial
- Trial
- Ii
- Intranasal
- Phase
- Two
- Administration
- Cold
- Common
- Effects
- Oral
- Side
- Treatment
clinical trials
- Trial
- Ii
- Intranasal
- Phase
- Administration
- Cold
- Common
- Effects
- Oral
- Side
- Treatment
- Symptoms

Connections between topic areas Semantic bridges

For Pleconaril, one of the stronger structural bridges in this analysis connects Pleconaril with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Pleconaril — Overview · splits 24 ⟂ 10

Pleconaril — History · splits 28 ⟂ 6

Pleconaril — Resistance · splits 28 ⟂ 6

Pleconaril — Mechanism of action · splits 29 ⟂ 5

Pleconaril — Clinical trials · splits 30 ⟂ 4

Map overview Semantic statistics

Pleconaril

Nodes34

Edges33

Triples79

Avg. degree1.94

Density0.058824

Components1

Source & methodology

TTTA analyzes the structure around Pleconaril to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Resistance & Mechanism of action, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pleconaril · EN edition · Analysis: TopicsToTalkAbout

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