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Phosphoglucomutase: Function, Disease relevance & Reaction mechanism

Phosphoglucomutase (EC 5.4.2.2) is an enzyme that transfers a phosphate group on an α-D-glucose monomer from the 1 to the 6 position in the forward direction or the 6 to the 1 position in the reverse direction.

Language: English [EN]
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Phosphoglucomutase topic overview

The analysis highlights Function, Disease relevance and Reaction mechanism as prominent areas in the source structure around Phosphoglucomutase.

Related topics
67
Source areas
6
Connected nodes
73
Extracted relationships
54
Concept neighborhoods
27
Bridge connections
73

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Disease relevance · 19 topics
Function · 19 topics
Reaction mechanism · 14 topics
Overview · 7 topics
Genes · 4 topics
Structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
9001-81-4
EC no.
5.4.2.2
ExPASy
NiceZyme view
KEGG
enzyme entry
MetaCyc
metabolic pathway

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Reaction mechanism

Structure

Disease relevance

Genes

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Phosphoglucomutase connects Entity context

The extracted context around Phosphoglucomutase shows recurring relationship patterns in the source. For example, Phosphoglucomutase → CDG, CDG1T, GSD XIV, Human, It, One, PGM, PGM II, PGM1, PGM1-CDG, The, There, This Another extracted example is Phosphoglucomutase → If, In, This, UDP-glucose, UDP-glucose-pyrophosphorylase, UTP. Use these groups to spot repeated connection types before inspecting the individual relationships.

Phosphoglucomutase

Top relations

related to Disease relevance · 13
Phosphoglucomutase → CDG, CDG1T, GSD XIV, Human, It, One, PGM, PGM II, PGM1, PGM1-CDG, The, There, This
related to Role in glycogenesis · 6
Phosphoglucomutase → If, In, This, UDP-glucose, UDP-glucose-pyrophosphorylase, UTP
see also · 6
Phosphoglucomutase → ADP, AMP, ATP, Beta-phosphoglucomutaseCongenital, Low ATP, Second
related to Role in glycogenolysis · 5
Phosphoglucomutase → After, Glucose, If, NADPH, This
related to Structure · 5
Phosphoglucomutase → Each, I-IV, Ser-116, The, While
related to Reaction mechanism · 4
Phosphoglucomutase → Isotopic, Later, Substrate-velocity, The
related to External links · 3
Phosphoglucomutase → Medicine Medical Subject Headings, MeSH, National Library
BRENDA · 1
Phosphoglucomutase → enzyme data
CAS no. · 1
Phosphoglucomutase → 9001-81-4
EC no. · 1
Phosphoglucomutase → 5.4.2.2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

glucose glycogen muscle enzyme atp exercise reaction 6-phosphate group pathway intermediate cell disease see also metabolic 1-phosphate dephosphorylated amp phosphate

Phosphoglucomutase relationships Subject–Predicate–Object triples

TTTA extracted 54 structured relationships around Phosphoglucomutase. Examples in this analysis include Phosphoglucomutase → BRENDA → enzyme data and Phosphoglucomutase → CAS no. → 9001-81-4. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PhosphoglucomutaseBRENDAenzyme data1.00infobox
PhosphoglucomutaseCAS no.9001-81-41.00infobox
PhosphoglucomutaseEC no.5.4.2.21.00infobox
PhosphoglucomutaseExPASyNiceZyme view1.00infobox
PhosphoglucomutaseKEGGenzyme entry1.00infobox
PhosphoglucomutaseMetaCycmetabolic pathway1.00infobox
PhosphoglucomutaseNCBIproteins1.00infobox
PhosphoglucomutasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
PhosphoglucomutasePMCarticles1.00infobox
PhosphoglucomutasePubMedarticles1.00infobox
PhosphoglucomutaseRheareactions1.00infobox
PhosphoglucomutaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Phosphoglucomutase bring nearby vocabulary together. In this analysis, examples include Glucose, See and 6-phosphate. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • glucose
    • 6-phosphate
    • Pathway
    • 6-bisphosphate
    • 1-phosphate
    • Intermediate
    • Phosphoglucomutase
    • Glycogen
    • Blood
    • Cell
    • Metabolic
    • Group
    • Reaction
  • glucose 6-phosphate
    • 6-phosphate
    • Glucose
    • Pathway
    • 6-bisphosphate
    • 1-phosphate
    • Intermediate
    • Cell
    • Phosphoglucomutase
    • Glycogen
    • Blood
    • Metabolic
    • Group
  • glycogen phosphorylase
    • Muscle
    • Exercise
    • Adp
    • Glucose-1-phosphate
    • Low
    • Reservoir
    • Glucose
    • Pathway
    • Atp
    • Blood
    • Cycle
    • Nucleotide
  • glycogen
    • Muscle
    • Exercise
    • Adp
    • Glucose-1-phosphate
    • Low
    • Reservoir
    • Glucose
    • Pathway
    • Atp
    • Blood
    • Cycle
    • Nucleotide
  • converted to glucose
    • Amp
    • 6-phosphate
    • Cycle
    • Nucleotide
    • Purine
    • Pathway
    • 6-bisphosphate
    • 1-phosphate
    • Atp
    • Intermediate
    • Phosphoglucomutase
    • Glycogen
  • glucose 6-phosphatase
    • 6-phosphate
    • Pathway
    • 6-bisphosphate
    • 1-phosphate
    • Intermediate
    • Phosphoglucomutase
    • Glycogen
    • Blood
    • Cell
    • Metabolic
    • Group
    • Reaction
  • glycogen synthase
    • Muscle
    • Exercise
    • Adp
    • Glucose-1-phosphate
    • Low
    • Reservoir
    • Glucose
    • Pathway
    • Atp
    • Blood
    • Cycle
    • Nucleotide
  • glucose 1,6-bisphosphate
    • Intermediate
    • 6-phosphate
    • Phosphoryl
    • Dephosphorylated
    • Pathway
    • Group
    • 6-bisphosphate
    • Glucose
    • 1-phosphate
    • Reaction
    • Phosphoglucomutase
    • Glycogen

Connections between topic areas Semantic bridges

For Phosphoglucomutase, one of the stronger structural bridges in this analysis connects Phosphoglucomutase with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PhosphoglucomutaseFunction · splits 54 ⟂ 20
PhosphoglucomutaseDisease relevance · splits 54 ⟂ 20
PhosphoglucomutaseReaction mechanism · splits 59 ⟂ 15
PhosphoglucomutaseOverview · splits 66 ⟂ 8
PhosphoglucomutaseStructure · splits 69 ⟂ 5
PhosphoglucomutaseGenes · splits 69 ⟂ 5

Map overview Semantic statistics

Phosphoglucomutase

Nodes74
Edges73
Triples54
Avg. degree1.97
Density0.027027
Components1

Source & methodology

TTTA analyzes the structure around Phosphoglucomutase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Disease relevance & Reaction mechanism, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Phosphoglucomutase · EN edition · Analysis: TopicsToTalkAbout

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