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Pharmacokinetics

Pharmacokinetics (from Ancient Greek pharmakon 'drug' and kinetikos 'moving, putting in motion'; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body affects a specific substance after administration. The substances of interest include any chemical xenobiotics such as pharmaceutical drugs…

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Overview

ADME

Metrics

Modeling

Bioavailability

Analysis

Population pharmacokinetics

Clinical pharmacokinetics

Ecotoxicology

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Map overview Semantic statistics

Pharmacokinetics

Nodes112
Edges111
Triples52
Avg. degree1.98
Density0.017857
Components1

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Pharmacokinetics

Top relations

related to Mass spectrometry · 10
Pharmacokinetics → Blank, LC-MS, Much, Recent, Secondary, SESI-MS, Standard, Tandem, The, There
related to Metrics · 6
Pharmacokinetics → AUC, AUCτ, In, Similarly, The, To
related to Clinical pharmacokinetics · 5
Pharmacokinetics → An, Clinical, However, The, This
related to Ecotoxicology · 5
Pharmacokinetics → Ecotoxicology, EPA, How, The, WHO
related to Modeling · 5
Pharmacokinetics → Clinical, Models, Multi-compartment, Pharmacokinetic, The
related to Population pharmacokinetics · 4
Pharmacokinetics → Additionally, Certain, For, Population
is a · 1
Pharmacokinetics → study of how an organism affects the drug

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Important terminology

drug elimination concentration distribution plasma drugs drug's models body metabolism bioavailability model dose used blood tissues pk compartment organism time

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Pharmacokineticsis astudy of how an organism affects the drug0.90text
pharmaceutical drugsinstance ofThe substances of interest include any chemical xenobiotics0.80text
pesticidesinstance ofThe substances of interest include any chemical xenobiotics0.80text
food additivesinstance ofThe substances of interest include any chemical xenobiotics0.80text
cosmeticsinstance ofThe substances of interest include any chemical xenobiotics0.80text
etcinstance ofThe substances of interest include any chemical xenobiotics0.80text
cytochrome P450 or glucuronosyltransferase enzymesinstance ofe.g. by metabolic enzymes0.80text
its acid dissociation constantinstance ofas well as how a particular drug will behave given information regarding some of its basic characteristics0.80text
Cmaxinstance ofparameters0.80text
chemical kineticsinstance ofPK compartmental models are often similar to kinetic models used in other scientific disciplines0.80text
thermodynamicsinstance ofPK compartmental models are often similar to kinetic models used in other scientific disciplines0.80text
quadratics since the response of most mass spectrometers is not linear across large concentration ranges.There is currently considerable interest in the use of very high sensitivity mass spectrometry for microdosing studiesinstance ofhowever it is common to use curve fitting with more complex functions0.80text

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