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Progesterone receptor membrane component 1 (abbreviated PGRMC1) is a protein which co-purifies with progesterone binding proteins in the liver and ovary. In humans, the PGRMC1 protein is encoded by the PGRMC1 gene.
The analysis highlights Binding to heme and cytochrome P450s, Expression and Roles in signaling and apoptosis as prominent areas in the source structure around PGRMC1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around PGRMC1 shows recurring relationship patterns in the source. For example, PGRMC1 → amyloid-beta binding, cell body, endomembrane system, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, heme binding, integral component of membrane, integral component of plasma membrane, intracellular membrane-bounded organelle, lipid binding, membrane, neuron projection, neutrophil degranulation, organelle membrane, plasma membrane, protein binding, smooth endoplasmic reticulum membrane, soma, specific granule membrane Another extracted example is PGRMC1 → anterior amygdaloid area, arcuate nucleus, bronchial epithelial cell, caput epididymis, corpus epididymis, dorsomedial hypothalamic nucleus, endometrium, lateral septal nucleus, left lobe of liver, middle temporal gyrus, olfactory epithelium, paraventricular nucleus of hypothalamus, pars compacta, pons, seminal vesicula, skin of thigh, suprachiasmatic nucleus, tail of epididymis, transitional epithelium of urinary bladder, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.
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protein gene progesterone human expression binding bp proteins also dap1 chr band yeast binds membrane liver cells component chromosome receptor
TTTA extracted 106 structured relationships around PGRMC1. Examples in this analysis include PGRMC1 → Aliases → PGRMC1, HPR6.6, MPR, progesterone receptor membrane component 1, Dap1, IZA, 25-Dx and PGRMC1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4X8Y. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PGRMC1 | Aliases | PGRMC1, HPR6.6, MPR, progesterone receptor membrane component 1, Dap1, IZA, 25-Dx | 1.00 | infobox |
| PGRMC1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4X8Y | 1.00 | infobox |
| PGRMC1 | Band | Xq24 | 1.00 | infobox |
| PGRMC1 | Band | X|X A3.3 | 1.00 | infobox |
| PGRMC1 | Bgee | seminal vesicula | 1.00 | infobox |
| PGRMC1 | Bgee | caput epididymis | 1.00 | infobox |
| PGRMC1 | Bgee | corpus epididymis | 1.00 | infobox |
| PGRMC1 | Bgee | tail of epididymis | 1.00 | infobox |
| PGRMC1 | Bgee | bronchial epithelial cell | 1.00 | infobox |
| PGRMC1 | Bgee | pons | 1.00 | infobox |
| PGRMC1 | Bgee | endometrium | 1.00 | infobox |
| PGRMC1 | Bgee | skin of thigh | 1.00 | infobox |
| PGRMC1 | Bgee | middle temporal gyrus | 1.00 | infobox |
| PGRMC1 | Bgee | pars compacta | 1.00 | infobox |
| PGRMC1 | Bgee | olfactory epithelium | 1.00 | infobox |
| PGRMC1 | Bgee | transitional epithelium of urinary bladder | 1.00 | infobox |
| PGRMC1 | Bgee | paraventricular nucleus of hypothalamus | 1.00 | infobox |
| PGRMC1 | Bgee | arcuate nucleus | 1.00 | infobox |
| PGRMC1 | Bgee | ventromedial nucleus | 1.00 | infobox |
| PGRMC1 | Bgee | suprachiasmatic nucleus | 1.00 | infobox |
| PGRMC1 | Bgee | anterior amygdaloid area | 1.00 | infobox |
| PGRMC1 | Bgee | lateral septal nucleus | 1.00 | infobox |
| PGRMC1 | Bgee | left lobe of liver | 1.00 | infobox |
| PGRMC1 | Bgee | dorsomedial hypothalamic nucleus | 1.00 | infobox |
| PGRMC1 | BioGPS | More reference expression data | 1.00 | infobox |
| PGRMC1 | Chr. | X chromosome (human) | 1.00 | infobox |
| PGRMC1 | Chr. | X chromosome (mouse) | 1.00 | infobox |
| PGRMC1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PGRMC1 | End | 119,244,466 bp | 1.00 | infobox |
| PGRMC1 | End | 35,869,732 bp | 1.00 | infobox |
The concept neighborhoods around PGRMC1 bring nearby vocabulary together. In this analysis, examples include Progesterone, Protein and Proteins. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PGRMC1, one of the stronger structural bridges in this analysis connects PGRMC1 with Binding to heme and cytochrome P450s. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PGRMC1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Binding to heme and cytochrome P450s, Expression & Roles in signaling and apoptosis, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PGRMC1 · EN edition · Analysis: TopicsToTalkAbout
