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Peripherin 2: Function, Clinical significance & Overview

Peripherin-2 is a protein, that in humans is encoded by the PRPH2 gene. Peripherin-2 is found in the rod and cone cells of the retina of the eye. Defects in this protein result in one form of retinitis pigmentosa, an incurable blindness.

Language: English [EN]
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Peripherin 2 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around Peripherin 2.

Related topics
13
Source areas
3
Connected nodes
16
Extracted relationships
59
Related term clusters
10
Bridge connections
16

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 6 topics
Overview · 6 topics
Clinical significance · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PRPH2, AOFMD, AVMD, CACD2, DS, PRPH, RDS, RP7, TSPAN22, rd2, MDBS1, Peripherin 2, peripherin 2 (retinal degeneration, slow)
Band
6p21.1 · 17 C|17 22.91 cM
Bgee
quadriceps femoris muscle · vastus lateralis muscle · muscle of thigh · deltoid muscle · testicle
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Peripherin 2 connects Entity context

The extracted context around Peripherin 2 shows recurring relationship patterns in the source. For example, Peripherin 2 → biceps brachii, deltoid muscle, embryo, epithelium of lens, gastrocnemius muscle, gonad, muscle of arm, muscle of thigh, neural layer of retina, nucleus of stria terminalis, outer nuclear layer, pineal gland, quadriceps femoris muscle, retinal pigment epithelium, Skeletal muscle tissue of biceps brachii, spermatid, testicle, vastus lateralis muscle Another extracted example is Peripherin 2 → Peripherin, RDS, Tetraspanins. Use these groups to spot repeated connection types before inspecting the individual relationships.

Peripherin 2

Top relations

Bgee · 18
Peripherin 2 → biceps brachii, deltoid muscle, embryo, epithelium of lens, gastrocnemius muscle, gonad, muscle of arm, muscle of thigh, neural layer of retina, nucleus of stria terminalis, outer nuclear layer, pineal gland, quadriceps femoris muscle, retinal pigment epithelium, Skeletal muscle tissue of biceps brachii, spermatid, testicle, vastus lateralis muscle
RNA expression pattern · 18
Peripherin 2 → biceps brachii, deltoid muscle, embryo, epithelium of lens, gastrocnemius muscle, gonad, muscle of arm, muscle of thigh, neural layer of retina, nucleus of stria terminalis, outer nuclear layer, pineal gland, quadriceps femoris muscle, retinal pigment epithelium, Skeletal muscle tissue of biceps brachii, spermatid, testicle, vastus lateralis muscle
related to Function · 3
Peripherin 2 → Peripherin, RDS, Tetraspanins
Band · 2
Peripherin 2 → 17 C|17 22.91 cM, 6p21.1
Chr. · 2
Peripherin 2 → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
Peripherin 2 → 42,722,597 bp, 47,235,859 bp
Aliases · 1
Peripherin 2 → PRPH2, AOFMD, AVMD, CACD2, DS, PRPH, RDS, RP7, TSPAN22, rd2, MDBS1, Peripherin 2, peripherin 2 (retinal degeneration, slow)
BioGPS · 1
Peripherin 2 → More reference expression data
Databases · 1
Peripherin 2 → NCBI: entry; OMA: entry
Ensembl · 1
Peripherin 2 → ENSG00000112619

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein bp prph2 chr human band chromosome location retinitis pigmentosa retinal peripherin-2 retina mouse peripherin outer external encoded found

Peripherin 2 relationships Subject–Predicate–Object triples

TTTA extracted 59 structured relationships around Peripherin 2. Examples in this analysis include Peripherin 2 → Aliases → PRPH2, AOFMD, AVMD, CACD2, DS, PRPH, RDS, RP7, TSPAN22, rd2, MDBS1, Peripherin 2, peripherin 2 (retinal degeneration, slow) and Peripherin 2 → Band → 6p21.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Peripherin 2AliasesPRPH2, AOFMD, AVMD, CACD2, DS, PRPH, RDS, RP7, TSPAN22, rd2, MDBS1, Peripherin 2, peripherin 2 (retinal degeneration, slow)1.00infobox
Peripherin 2Band6p21.11.00infobox
Peripherin 2Band17 C|17 22.91 cM1.00infobox
Peripherin 2Bgeequadriceps femoris muscle1.00infobox
Peripherin 2Bgeevastus lateralis muscle1.00infobox
Peripherin 2Bgeemuscle of thigh1.00infobox
Peripherin 2Bgeedeltoid muscle1.00infobox
Peripherin 2Bgeetesticle1.00infobox
Peripherin 2Bgeegastrocnemius muscle1.00infobox
Peripherin 2Bgeegonad1.00infobox
Peripherin 2Bgeemuscle of arm1.00infobox
Peripherin 2Bgeebiceps brachii1.00infobox
Peripherin 2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
Peripherin 2Bgeeneural layer of retina1.00infobox
Peripherin 2Bgeeepithelium of lens1.00infobox
Peripherin 2Bgeeretinal pigment epithelium1.00infobox
Peripherin 2Bgeeembryo1.00infobox
Peripherin 2Bgeeouter nuclear layer1.00infobox
Peripherin 2Bgeepineal gland1.00infobox
Peripherin 2Bgeenucleus of stria terminalis1.00infobox
Peripherin 2Bgeespermatid1.00infobox
Peripherin 2BioGPSMore reference expression data1.00infobox
Peripherin 2Chr.Chromosome 6 (human)1.00infobox
Peripherin 2Chr.Chromosome 17 (mouse)1.00infobox
Peripherin 2DatabasesNCBI: entry; OMA: entry1.00infobox
Peripherin 2End42,722,597 bp1.00infobox
Peripherin 2End47,235,859 bp1.00infobox
Peripherin 2EnsemblENSG000001126191.00infobox
Peripherin 2Entrez59611.00infobox
Peripherin 2External IDsOMIM: 179605; MGI: 102791; GeneCards: PRPH21.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Peripherin 2 bring nearby vocabulary together. In this analysis, examples include Rds, Outer and Rod. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Prph2
    • Location
    • Retinal
    • Chromosome
    • Human
    • Bp
    • Chr
    • Associated
    • End
    • Mouse
    • Band
    • Protein
  • protein
    • Prph2
    • Defects
    • End
    • Entry
    • Mouse
    • Ncbi
    • Retina
    • Location
    • Outer
    • Pigmentosa
    • Retinal
    • Retinitis
  • retina
    • End
    • Entry
    • Mouse
    • Ncbi
    • Rod
    • Location
    • Outer
    • Retinal
    • Band
    • Chromosome
    • Human
    • Prph2
  • function
    • Peripherin
    • Rds
    • Location
    • Outer
    • Retinal
    • Chromosome
    • Human
    • Prph2
    • Bp
    • Chr
    • Gene
  • retinitis pigmentosa
    • Pigmentosa
    • Retinitis
    • Defects
    • Dystrophy
    • Entry
    • Macular
    • Ncbi
    • Protein
  • outer segment disks
    • Peripherin
    • Ncbi
    • Rds
    • Retina
    • Rod
    • Retinal
    • Prph2
    • Protein
  • Peripherin 2
    • Rds
    • Outer
    • Rod
    • Location
    • Retinal
    • Human
    • Prph2
  • peripherin 2
    • Rds
    • Outer
    • Rod
    • Location
    • Retinal
    • Human
    • Prph2

Connections between topic areas Semantic bridges

For Peripherin 2, one of the stronger structural bridges in this analysis connects Peripherin 2 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Peripherin 2 — Overview · splits 10 ⟂ 7
Peripherin 2 — Function · splits 10 ⟂ 7

Map overview Semantic statistics

Peripherin 2

Nodes17
Edges16
Triples59
Avg. degree1.88
Density0.117647
Components1

Source & methodology

TTTA analyzes the structure around Peripherin 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Peripherin 2 · EN edition · Analysis: TopicsToTalkAbout

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