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Twinkle (protein)

Twinkle protein also known as twinkle mtDNA helicase is a mitochondrial protein that in humans is encoded by the TWNK gene (also known as C10orf2 or PEO1) located in the long arm of chromosome 10 (10q24.31).

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5.6.2.3
Aliases
TWNK, ATXN8, IOSCA, MTDPS7, PEO, PEO1, PEOA3, SANDO, SCA8, TWINL, PRLTS5, C10orf2, chromosome 10 open reading frame 2, twinkle mtDNA helicase
Band
10q24.31 · 19 C3|19 38.19 cM
Bgee
testicle · gastrocnemius muscle · ventricular zone · gonad · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

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Map overview Semantic statistics

Twinkle (protein)

Nodes27
Edges26
Triples83
Avg. degree1.93
Density0.074074
Components1

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Twinkle (protein)

Top relations

Bgee · 19
Twinkle (protein) → abdominal wall, autopod region, cumulus cell, epiblast, foot, ganglionic eminence, gastrocnemius muscle, glutes, gonad, interventricular septum, left adrenal cortex, left adrenal gland, mucosa of transverse colon, muscle of thigh, otic vesicle, right adrenal gland, superior cervical ganglion, testicle, ventricular zone
Gene ontology · 19
Twinkle (protein) → 5'-3' DNA helicase activity, ATP binding, cellular response to glucose stimulus, DNA helicase activity, DNA replication, DNA unwinding involved in DNA replication, helicase activity, hydrolase activity, mitochondrial DNA replication, mitochondrial matrix, mitochondrial nucleoid, mitochondrial transcription, mitochondrion, mitochondrion organization, nucleotide binding, protease binding, protein hexamerization, protein homooligomerization, single-stranded DNA binding
RNA expression pattern · 19
Twinkle (protein) → abdominal wall, autopod region, cumulus cell, epiblast, foot, ganglionic eminence, gastrocnemius muscle, glutes, gonad, interventricular septum, left adrenal cortex, left adrenal gland, mucosa of transverse colon, muscle of thigh, otic vesicle, right adrenal gland, superior cervical ganglion, testicle, ventricular zone
Band · 2
Twinkle (protein) → 10q24.31, 19 C3|19 38.19 cM
Chr. · 2
Twinkle (protein) → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
Twinkle (protein) → 100,994,403 bp, 45,001,201 bp
5.6.2.3 · 1
Twinkle (protein) → ↗
Aliases · 1
Twinkle (protein) → TWNK, ATXN8, IOSCA, MTDPS7, PEO, PEO1, PEOA3, SANDO, SCA8, TWINL, PRLTS5, C10orf2, chromosome 10 open reading frame 2, twinkle mtDNA helicase
BioGPS · 1
Twinkle (protein) → More reference expression data
Databases · 1
Twinkle (protein) → NCBI: entry; OMA: entry

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Important terminology

mtdna twinkle protein helicase gene mitochondrial dna human bp chromosome 10 twnk chr band function disease unwinding ataxia known mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Twinkle (protein)5.6.2.31.00infobox
Twinkle (protein)AliasesTWNK, ATXN8, IOSCA, MTDPS7, PEO, PEO1, PEOA3, SANDO, SCA8, TWINL, PRLTS5, C10orf2, chromosome 10 open reading frame 2, twinkle mtDNA helicase1.00infobox
Twinkle (protein)Band10q24.311.00infobox
Twinkle (protein)Band19 C3|19 38.19 cM1.00infobox
Twinkle (protein)Bgeetesticle1.00infobox
Twinkle (protein)Bgeegastrocnemius muscle1.00infobox
Twinkle (protein)Bgeeventricular zone1.00infobox
Twinkle (protein)Bgeegonad1.00infobox
Twinkle (protein)Bgeeganglionic eminence1.00infobox
Twinkle (protein)Bgeeglutes1.00infobox
Twinkle (protein)Bgeeleft adrenal gland1.00infobox
Twinkle (protein)Bgeeleft adrenal cortex1.00infobox
Twinkle (protein)Bgeemucosa of transverse colon1.00infobox
Twinkle (protein)Bgeeright adrenal gland1.00infobox
Twinkle (protein)Bgeeepiblast1.00infobox
Twinkle (protein)Bgeeinterventricular septum1.00infobox
Twinkle (protein)Bgeeautopod region1.00infobox
Twinkle (protein)Bgeesuperior cervical ganglion1.00infobox
Twinkle (protein)Bgeemuscle of thigh1.00infobox
Twinkle (protein)Bgeecumulus cell1.00infobox
Twinkle (protein)Bgeefoot1.00infobox
Twinkle (protein)Bgeeabdominal wall1.00infobox
Twinkle (protein)Bgeeotic vesicle1.00infobox
Twinkle (protein)BioGPSMore reference expression data1.00infobox
Twinkle (protein)Chr.Chromosome 10 (human)1.00infobox
Twinkle (protein)Chr.Chromosome 19 (mouse)1.00infobox
Twinkle (protein)DatabasesNCBI: entry; OMA: entry1.00infobox
Twinkle (protein)End100,994,403 bp1.00infobox
Twinkle (protein)End45,001,201 bp1.00infobox
Twinkle (protein)EnsemblENSG000001078151.00infobox

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