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Nusinersen, marketed as Spinraza, is a medication used in treating spinal muscular atrophy (SMA), a rare neuromuscular disorder. In December 2016, it became the first approved drug used in treating this disorder.
The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Nusinersen.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Nusinersen shows recurring relationship patterns in the source. For example, Nusinersen → Adrian Krainer, Biogen, Cold Spring Harbor Laboratory, Cure SMA, Initial, Ionis, Ionis Pharmaceuticals, Isis Pharmaceuticals, Massachusetts, Massachusetts Medical School, Ravindra, Singh, Starting, University, US Another extracted example is Nusinersen → According, Denmark, In October, SMA, The New York Times, US, USA. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
drug sma people spinal 2018 price muscular atrophy approved used us protein gene clinical type children treatment 2017 2019 december
TTTA extracted 57 structured relationships around Nusinersen. Examples in this analysis include Nusinersen → AHFS/Drugs.com → Monograph and Nusinersen → ATC code → M09AX07 (WHO). The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Nusinersen | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Nusinersen | ATC code | M09AX07 (WHO) | 1.00 | infobox |
| Nusinersen | Bioavailability | 100% (intrathecal) | 1.00 | infobox |
| Nusinersen | CAS Number | 1258984-36-9 | 1.00 | infobox |
| Nusinersen | ChemSpider | 34983394 | 1.00 | infobox |
| Nusinersen | DrugBank | DB13161 | 1.00 | infobox |
| Nusinersen | Elimination half-life | 135–177 days (in CSF), 63–87 days (in plasma) | 1.00 | infobox |
| Nusinersen | Formula | C234H323N61Na17O128P17S17 | 1.00 | infobox |
| Nusinersen | KEGG | D10881 | 1.00 | infobox |
| Nusinersen | KEGG | as salt: D10791 | 1.00 | infobox |
| Nusinersen | Legal status | AU: S4 (Prescription only) | 1.00 | infobox |
| Nusinersen | Legal status | CA: ℞-only | 1.00 | infobox |
| Nusinersen | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Nusinersen | Legal status | US: ℞-only | 1.00 | infobox |
| Nusinersen | Legal status | EU: Rx-only | 1.00 | infobox |
| Nusinersen | License data | US DailyMed: Nusinersen | 1.00 | infobox |
| Nusinersen | MedlinePlus | a617010 | 1.00 | infobox |
| Nusinersen | Metabolism | Exonuclease (3'- and 5')-mediated hydrolysis | 1.00 | infobox |
| Nusinersen | Molar mass | 7500.86 g·mol−1 | 1.00 | infobox |
| Nusinersen | Other names | IONIS-SMNRx, ISIS-SMNRx | 1.00 | infobox |
| Nusinersen | Pregnancy category | AU: B1 | 1.00 | infobox |
| Nusinersen | Protein binding | <25% (in CSF), >94% (in plasma) | 1.00 | infobox |
| Nusinersen | PubChem CID | 124037382 | 1.00 | infobox |
| Nusinersen | Routes of administration | Intrathecal | 1.00 | infobox |
| Nusinersen | Trade names | Spinraza | 1.00 | infobox |
| Nusinersen | UNII | 5Z9SP3X666 | 1.00 | infobox |
The concept neighborhoods around Nusinersen bring nearby vocabulary together. In this analysis, examples include Sma, Us and Price. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Nusinersen, one of the stronger structural bridges in this analysis connects Nusinersen with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Nusinersen to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Nusinersen · EN edition · Analysis: TopicsToTalkAbout
