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NRXN1: Function, Interactions & Genomics

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.

Language: English [EN]
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NRXN1 topic overview

The analysis highlights Function, Interactions and Genomics as prominent areas in the source structure around NRXN1.

Related topics
17
Source areas
4
Connected nodes
21
Extracted relationships
170
Concept neighborhoods
12
Bridge connections
21

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 8 topics
Overview · 6 topics
Interactions · 2 topics
Genomics · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3B3Q
Band
2p16.3 · 17|17 E5
Bgee
sural nerve · middle temporal gyrus · superior frontal gyrus · parietal lobe · postcentral gyrus
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Genomics

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NRXN1 connects Entity context

The extracted context around NRXN1 shows recurring relationship patterns in the source. For example, NRXN1 → acetylcholine receptor binding, adult behavior, angiogenesis, axon guidance, axonal growth cone, calcium channel regulator activity, calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, calcium-dependent protein binding, cell adhesion, cell adhesion molecule binding, cell junction, cell surface, cellular response to calcium ion, cerebellar granule cell differentiation, chemical synaptic transmission, endocytic vesicle, endoplasmic reticulum, establishment of protein localization, GABA-ergic synapse Another extracted example is NRXN1 → anterior amygdaloid area, Brodmann area 23, cingulate gyrus, dentate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal lobe, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, superior frontal gyrus, sural nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

NRXN1

Top relations

Gene ontology · 93
NRXN1 → acetylcholine receptor binding, adult behavior, angiogenesis, axon guidance, axonal growth cone, calcium channel regulator activity, calcium ion binding, calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, calcium-dependent protein binding, cell adhesion, cell adhesion molecule binding, cell junction, cell surface, cellular response to calcium ion, cerebellar granule cell differentiation, chemical synaptic transmission, endocytic vesicle, endoplasmic reticulum, establishment of protein localization, GABA-ergic synapse
Bgee · 20
NRXN1 → anterior amygdaloid area, Brodmann area 23, cingulate gyrus, dentate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal lobe, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, superior frontal gyrus, sural nerve, ventricular zone
RNA expression pattern · 20
NRXN1 → anterior amygdaloid area, Brodmann area 23, cingulate gyrus, dentate gyrus, dentate gyrus of hippocampal formation granule cell, entorhinal cortex, lateral geniculate nucleus, lateral nuclear group of thalamus, medial dorsal nucleus, medial geniculate nucleus, middle temporal gyrus, parietal lobe, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, superior frontal gyrus, sural nerve, ventricular zone
related to Function · 10
NRXN1 → Autism, GABA, Implications, Neurexins, NRXN1a, Social, Structural, These, They, This
related to Genomics · 3
NRXN1 → Crick, Mutations, The
Band · 2
NRXN1 → 17|17 E5, 2p16.3
Chr. · 2
NRXN1 → Chromosome 17 (mouse), Chromosome 2 (human)
End · 2
NRXN1 → 51,225,575 bp, 91,093,071 bp
Aliases · 1
NRXN1 → NRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1
Available structures · 1
NRXN1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3B3Q

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp autism chr band protein chromosome function neurexins social molecules location encoded genes two transcripts isoforms alpha-neurexins contain

NRXN1 relationships Subject–Predicate–Object triples

TTTA extracted 170 structured relationships around NRXN1. Examples in this analysis include NRXN1 → Aliases → NRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1 and NRXN1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3B3Q. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NRXN1AliasesNRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 11.00infobox
NRXN1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3B3Q1.00infobox
NRXN1Band2p16.31.00infobox
NRXN1Band17|17 E51.00infobox
NRXN1Bgeesural nerve1.00infobox
NRXN1Bgeemiddle temporal gyrus1.00infobox
NRXN1Bgeesuperior frontal gyrus1.00infobox
NRXN1Bgeeparietal lobe1.00infobox
NRXN1Bgeepostcentral gyrus1.00infobox
NRXN1BgeeBrodmann area 231.00infobox
NRXN1Bgeeentorhinal cortex1.00infobox
NRXN1Bgeeprimary visual cortex1.00infobox
NRXN1Bgeeventricular zone1.00infobox
NRXN1Bgeelateral nuclear group of thalamus1.00infobox
NRXN1Bgeemedial dorsal nucleus1.00infobox
NRXN1Bgeemedial geniculate nucleus1.00infobox
NRXN1Bgeelateral geniculate nucleus1.00infobox
NRXN1Bgeeanterior amygdaloid area1.00infobox
NRXN1Bgeecingulate gyrus1.00infobox
NRXN1Bgeeprimary motor cortex1.00infobox
NRXN1Bgeedentate gyrus1.00infobox
NRXN1Bgeeprefrontal cortex1.00infobox
NRXN1Bgeepiriform cortex1.00infobox
NRXN1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
NRXN1BioGPSMore reference expression data1.00infobox
NRXN1Chr.Chromosome 2 (human)1.00infobox
NRXN1Chr.Chromosome 17 (mouse)1.00infobox
NRXN1DatabasesNCBI: entry; OMA: entry1.00infobox
NRXN1End51,225,575 bp1.00infobox
NRXN1End91,093,071 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NRXN1 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NRXN1
    • Gene
    • Human
    • Function
    • Location
    • Mutations
    • Protein
    • Bp
    • Chr
    • Chromosome
    • Autism
    • External
    • Adhesion
  • nrxn1
    • Gene
    • Human
    • Function
    • Location
    • Mutations
    • Protein
    • Bp
    • Chr
    • Chromosome
    • Autism
    • External
    • Adhesion
  • gene
    • Chromosome
    • Location
    • Nrxn1
    • Protein
    • Bp
    • Chr
    • Human
    • Autism
    • Mouse
    • Function
    • Band
    • Social
  • autism
    • Social
    • Mutations
    • Gene
    • Nrxn1
    • Cell
    • Exons
    • Family
    • Growth
    • Molecules
    • Mouse
    • Mrna
    • P58400
  • autism spectrum disorder
    • Social
    • Mutations
    • Gene
    • Nrxn1
    • Cell
    • Exons
    • Family
    • Growth
    • Molecules
    • Mouse
    • Mrna
    • P58400
  • function
    • Adhesion
    • Cell
    • Molecules
    • Proteins
    • Location
    • Neurexins
    • Bp
    • Chr
    • Chromosome
    • External
    • Human
    • Growth
  • neurexins
    • Adhesion
    • Cell
    • Molecules
    • Proteins
    • Function
    • Growth
    • Mouse
    • Mrna
    • P58400
    • Uniprot
    • Communication
    • Location
  • cell-adhesion molecules
    • Proteins
    • Neurexins
    • Growth
    • Mouse
    • Mrna
    • P58400
    • Uniprot
    • Location
    • Band
    • Protein
    • Social
    • Bp

Connections between topic areas Semantic bridges

For NRXN1, one of the stronger structural bridges in this analysis connects NRXN1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NRXN1Function · splits 13 ⟂ 9
NRXN1Overview · splits 15 ⟂ 7
NRXN1Interactions · splits 19 ⟂ 3

Map overview Semantic statistics

NRXN1

Nodes22
Edges21
Triples170
Avg. degree1.91
Density0.090909
Components1

Source & methodology

TTTA analyzes the structure around NRXN1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Genomics, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NRXN1 · EN edition · Analysis: TopicsToTalkAbout

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