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MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.
The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around MKL1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around MKL1 shows recurring relationship patterns in the source. For example, MKL1 → blood, body of uterus, bone marrow cell, CA3 field, dentate gyrus of hippocampal formation granule cell, granular layer of dentate gyrus, granulocyte, Ileal epithelium, layer of dentate gyrus, left testis, mesenteric lymph nodes, monocyte, olfactory tubercle, popliteal artery, pyramidal layer of hippocampus, right testis, stromal cell of endometrium, tibial arteries Another extracted example is MKL1 → actin binding, actin cytoskeleton organization, actin monomer binding, cytoplasm, cytosol, leucine zipper domain binding, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, regulation of transcription, DNA-templated, smooth muscle cell differentiation, transcription by RNA polymerase II, transcription coactivator activity, transcription, DNA-templated. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp gene chr human band transcription chromosome 22 mrtfa factor myocardin protein also leukemia related location nucleus mouse translocation mkl
TTTA extracted 75 structured relationships around MKL1. Examples in this analysis include MKL1 → Aliases → MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A and MKL1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KVU, 2KW9. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MKL1 | Aliases | MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A | 1.00 | infobox |
| MKL1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KVU, 2KW9 | 1.00 | infobox |
| MKL1 | Band | 22q13.1-q13.2 | 1.00 | infobox |
| MKL1 | Band | 15|15 E1 | 1.00 | infobox |
| MKL1 | Bgee | monocyte | 1.00 | infobox |
| MKL1 | Bgee | granulocyte | 1.00 | infobox |
| MKL1 | Bgee | popliteal artery | 1.00 | infobox |
| MKL1 | Bgee | tibial arteries | 1.00 | infobox |
| MKL1 | Bgee | right testis | 1.00 | infobox |
| MKL1 | Bgee | bone marrow cell | 1.00 | infobox |
| MKL1 | Bgee | left testis | 1.00 | infobox |
| MKL1 | Bgee | body of uterus | 1.00 | infobox |
| MKL1 | Bgee | blood | 1.00 | infobox |
| MKL1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| MKL1 | Bgee | layer of dentate gyrus | 1.00 | infobox |
| MKL1 | Bgee | granular layer of dentate gyrus | 1.00 | infobox |
| MKL1 | Bgee | olfactory tubercle | 1.00 | infobox |
| MKL1 | Bgee | pyramidal layer of hippocampus | 1.00 | infobox |
| MKL1 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| MKL1 | Bgee | Ileal epithelium | 1.00 | infobox |
| MKL1 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| MKL1 | Bgee | CA3 field | 1.00 | infobox |
| MKL1 | BioGPS | More reference expression data | 1.00 | infobox |
| MKL1 | Chr. | Chromosome 22 (human) | 1.00 | infobox |
| MKL1 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| MKL1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MKL1 | End | 40,636,719 bp | 1.00 | infobox |
| MKL1 | End | 81,074,958 bp | 1.00 | infobox |
| MKL1 | Ensembl | ENSG00000196588 | 1.00 | infobox |
| MKL1 | Entrez | 57591 | 1.00 | infobox |
The concept neighborhoods around MKL1 bring nearby vocabulary together. In this analysis, examples include Clinical, Mrtfa and Myocardin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MKL1, one of the stronger structural bridges in this analysis connects MKL1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MKL1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MKL1 · EN edition · Analysis: TopicsToTalkAbout
