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MKL1

MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.

Function, Clinical significance & Overview

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Function

3 related topics

Clinical significance

1 related topics

Overview

2 related topics

Key facts & relationships

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Aliases
MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KVU, 2KW9
Band
22q13.1-q13.2 · 15|15 E1
Bgee
monocyte · granulocyte · popliteal artery · tibial arteries · right testis
BioGPS
More reference expression data
Chr.
Chromosome 22 (human) · Chromosome 15 (mouse)

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Overview

Function

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

MKL1

Nodes10
Edges9
Triples75
Avg. degree1.8
Density0.2
Components1

How this topic connects Entity context

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MKL1

Top relations

Bgee · 18
MKL1 → blood, body of uterus, bone marrow cell, CA3 field, dentate gyrus of hippocampal formation granule cell, granular layer of dentate gyrus, granulocyte, Ileal epithelium, layer of dentate gyrus, left testis, mesenteric lymph nodes, monocyte, olfactory tubercle, popliteal artery, pyramidal layer of hippocampus, right testis, stromal cell of endometrium, tibial arteries
RNA expression pattern · 18
MKL1 → blood, body of uterus, bone marrow cell, CA3 field, dentate gyrus of hippocampal formation granule cell, granular layer of dentate gyrus, granulocyte, Ileal epithelium, layer of dentate gyrus, left testis, mesenteric lymph nodes, monocyte, olfactory tubercle, popliteal artery, pyramidal layer of hippocampus, right testis, stromal cell of endometrium, tibial arteries
Gene ontology · 15
MKL1 → actin binding, actin cytoskeleton organization, actin monomer binding, cytoplasm, cytosol, leucine zipper domain binding, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, regulation of transcription, DNA-templated, smooth muscle cell differentiation, transcription by RNA polymerase II, transcription coactivator activity, transcription, DNA-templated
Band · 2
MKL1 → 15|15 E1, 22q13.1-q13.2
Chr. · 2
MKL1 → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
MKL1 → 40,636,719 bp, 81,074,958 bp
Aliases · 1
MKL1 → MRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A
Available structures · 1
MKL1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KVU, 2KW9
BioGPS · 1
MKL1 → More reference expression data
Databases · 1
MKL1 → NCBI: entry; OMA: entry

Important terminology Word statistics

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Important terminology

bp gene chr human band transcription chromosome 22 mrtfa factor myocardin protein also leukemia related location nucleus mouse translocation mkl

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MKL1AliasesMRTFA, BSAC, MAL, MRTF-A, megakaryoblastic leukemia (translocation) 1, MKL, MKL1, myocardin related transcription factor A1.00infobox
MKL1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2KVU, 2KW91.00infobox
MKL1Band22q13.1-q13.21.00infobox
MKL1Band15|15 E11.00infobox
MKL1Bgeemonocyte1.00infobox
MKL1Bgeegranulocyte1.00infobox
MKL1Bgeepopliteal artery1.00infobox
MKL1Bgeetibial arteries1.00infobox
MKL1Bgeeright testis1.00infobox
MKL1Bgeebone marrow cell1.00infobox
MKL1Bgeeleft testis1.00infobox
MKL1Bgeebody of uterus1.00infobox
MKL1Bgeeblood1.00infobox
MKL1Bgeestromal cell of endometrium1.00infobox
MKL1Bgeelayer of dentate gyrus1.00infobox
MKL1Bgeegranular layer of dentate gyrus1.00infobox
MKL1Bgeeolfactory tubercle1.00infobox
MKL1Bgeepyramidal layer of hippocampus1.00infobox
MKL1Bgeemesenteric lymph nodes1.00infobox
MKL1BgeeIleal epithelium1.00infobox
MKL1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
MKL1BgeeCA3 field1.00infobox
MKL1BioGPSMore reference expression data1.00infobox
MKL1Chr.Chromosome 22 (human)1.00infobox
MKL1Chr.Chromosome 15 (mouse)1.00infobox
MKL1DatabasesNCBI: entry; OMA: entry1.00infobox
MKL1End40,636,719 bp1.00infobox
MKL1End81,074,958 bp1.00infobox
MKL1EnsemblENSG000001965881.00infobox
MKL1Entrez575911.00infobox

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