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Mitapivat

Mitapivat, sold under the brand name Pyrukynd among others, is a medication used to treat different types of anemia. It is taken as the sulfate hydrate salt by mouth. Mitapivat is a pyruvate kinase activator.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
B06AX04 (WHO)
CAS Number
1260075-17-9
ChEMBL
ChEMBL4299940 · as salt: ChEMBL4297223
ChemSpider
29763395

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Medical uses

Society and culture

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Map overview Semantic statistics

Mitapivat

Nodes19
Edges18
Triples115
Avg. degree1.89
Density0.105263
Components1

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Mitapivat

Top relations

related to history · 25
Mitapivat → Brazil, Canada, Denmark, Drug Administration, France, Germany, In, In Trial, Ireland, Italy, Japan, Korea, NCT03548220, NCT03559699, Neither, Netherlands, Republic, Spain, Switzerland, Thailand
related to External links · 24
Mitapivat → AG-348, Beta-Thalassemia, Clinical, ClinicalTrials, Deficiency, Efficacy, ENERGIZE-T, Evaluate Efficacy, NCT03548220, NCT03559699, NCT04770753, NCT04770779, Not Regularly Transfused Adult, NTDT, Participants With Non-Transfusion-Dependent Alpha, Participants With Pyruvate Kinase, Participants With Transfusion-Dependent Alpha, PKD, Regularly Transfused Adult Participants, Safety
related to Further reading · 19
Mitapivat → AG-348, ATP, Blood, Chen, Chubukov, Cianchetta, Haematologica, Histen, Hixon, January, Johnson, Kosinski PA, Kung, PKLR, PMC, PMID, Rab MA, September, Van Oirschot BA
related to Legal status · 12
Mitapivat → Agios Netherlands, CHMP, Committee, EMA, European Medicines Agency, European Union, Human Use, In September, Medicinal Products, November, Pyrukynd, The
related to Mechanism of action · 4
Mitapivat → ATP, DPG, Mutations, RBC
related to Medical uses · 3
Mitapivat → Aqvesme, In December, US
related to Names · 3
Mitapivat → Aqvesme, INN, Pyrukynd
ChEMBL · 2
Mitapivat → as salt: ChEMBL4297223, ChEMBL4299940
DrugBank · 2
Mitapivat → as salt: DBSALT003215, DB16236
Legal status · 2
Mitapivat → EU: Rx-only, US: ℞-only

Important terminology Word statistics

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Important terminology

pyruvate kinase trial deficiency pyrukynd us salt blood participants approved medical medication ag-348 activator drug administration anemia names treatment brand

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mitapivat3D model (JSmol)Interactive image1.00infobox
MitapivatAHFS/Drugs.comMonograph1.00infobox
MitapivatATC codeB06AX04 (WHO)1.00infobox
MitapivatCAS Number1260075-17-91.00infobox
MitapivatChEMBLChEMBL42999401.00infobox
MitapivatChEMBLas salt: ChEMBL42972231.00infobox
MitapivatChemSpider297633951.00infobox
MitapivatDrug classPyruvate kinase activator1.00infobox
MitapivatDrugBankDB162361.00infobox
MitapivatDrugBankas salt: DBSALT0032151.00infobox
MitapivatFormulaC24H26N4O3S1.00infobox
MitapivatIUPHAR/BPS104731.00infobox
MitapivatKEGGas salt: D114081.00infobox
MitapivatLegal statusUS: ℞-only1.00infobox
MitapivatLegal statusEU: Rx-only1.00infobox
MitapivatLicense dataUS DailyMed: Mitapivat1.00infobox
MitapivatMedlinePlusa6220181.00infobox
MitapivatMolar mass450.56 g·mol−11.00infobox
MitapivatOther namesAG-348, Mitapivat sulfate (USAN US)1.00infobox
MitapivatPubChem CID596347411.00infobox
MitapivatRoutes of administrationBy mouth1.00infobox
MitapivatTrade namesPyrukynd1.00infobox
MitapivatUNII2WTV10SIKH1.00infobox
MitapivatUNIIas salt: N4JTA67V3O1.00infobox
Mitapivatis apyruvate kinase activator.The most common side effects include decreases in estrone and estradiol0.90text

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