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Microcephalin: Research, Evolution & Other MCPH genes

Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1, when homozygous, cause primary microcephaly—a severely diminished brain. Hence, it has been assumed that variants have a role in brain development. However, in normal individuals no effect on mental ability or behavior has yet been demonstrated…

Language: English [EN]
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Microcephalin topic overview

The analysis highlights Research, Evolution and Other MCPH genes as prominent areas in the source structure around Microcephalin.

Related topics
43
Source areas
7
Connected nodes
50
Extracted relationships
89
Related term clusters
16
Bridge connections
50

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Evolution · 8 topics
Other MCPH genes · 8 topics
Controversy · 6 topics
Expression in the brain · 5 topics
Structure · 4 topics
Research studies · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
MCPH1, BRIT1, MCT, microcephalin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM
Band
8p23.1 · 8|8 A1.3
Bgee
secondary oocyte · ganglionic eminence · Achilles tendon · ventricular zone · bone marrow cell
BioGPS
n/a
Chr.
Chromosome 8 (human) · Chromosome 8 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Expression in the brain

Evolution

Controversy

Other MCPH genes

Research studies

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Microcephalin connects Entity context

The extracted context around Microcephalin shows recurring relationship patterns in the source. For example, Microcephalin → Achilles tendon, bone marrow cell, epiblast, ganglionic eminence, gastrocnemius muscle, genital tubercle, hand, muscle of thigh, otic vesicle, popliteal artery, primary oocyte, primitive streak, secondary oocyte, spermatocyte, tail of embryo, testicle, tibial arteries, ventricular zone, zygote Another extracted example is Microcephalin → bone development, cerebral cortex development, cytoplasm, cytoskeleton, establishment of mitotic spindle orientation, identical protein binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, nucleoplasm, protein binding, protein localization to centrosome, regulation of centrosome cycle, regulation of chromosome condensation, regulation of gene expression, regulation of inflammatory response, regulation of kinase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

Microcephalin

Top relations

Bgee · 19
Microcephalin → Achilles tendon, bone marrow cell, epiblast, ganglionic eminence, gastrocnemius muscle, genital tubercle, hand, muscle of thigh, otic vesicle, popliteal artery, primary oocyte, primitive streak, secondary oocyte, spermatocyte, tail of embryo, testicle, tibial arteries, ventricular zone, zygote
RNA expression pattern · 19
Microcephalin → Achilles tendon, bone marrow cell, epiblast, ganglionic eminence, gastrocnemius muscle, genital tubercle, hand, muscle of thigh, otic vesicle, popliteal artery, primary oocyte, primitive streak, secondary oocyte, spermatocyte, tail of embryo, testicle, tibial arteries, ventricular zone, zygote
Gene ontology · 17
Microcephalin → bone development, cerebral cortex development, cytoplasm, cytoskeleton, establishment of mitotic spindle orientation, identical protein binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, nucleoplasm, protein binding, protein localization to centrosome, regulation of centrosome cycle, regulation of chromosome condensation, regulation of gene expression, regulation of inflammatory response, regulation of kinase activity
related to Evolution · 7
Microcephalin → ASPM, Homo, IQ, MCPH1, Neanderthal, Sub-Saharan Africa, While Neanderthals
related to Structure · 4
Microcephalin → C-terminal BRCT, InterPro, IPR022047, N-terminal BRCT
Band · 2
Microcephalin → 8p23.1, 8|8 A1.3
Chr. · 2
Microcephalin → Chromosome 8 (human), Chromosome 8 (mouse)
End · 2
Microcephalin → 18,853,205 bp, 6,648,508 bp
Aliases · 1
Microcephalin → MCPH1, BRIT1, MCT, microcephalin 1
Available structures · 1
Microcephalin → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mcph1 brain gene bp human microcephaly chr band chromosome genes studies development variants aspm cdk5rap2 structure expressed location may later

Microcephalin relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around Microcephalin. Examples in this analysis include Microcephalin → Aliases → MCPH1, BRIT1, MCT, microcephalin 1 and Microcephalin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
MicrocephalinAliasesMCPH1, BRIT1, MCT, microcephalin 11.00infobox
MicrocephalinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM1.00infobox
MicrocephalinBand8p23.11.00infobox
MicrocephalinBand8|8 A1.31.00infobox
MicrocephalinBgeesecondary oocyte1.00infobox
MicrocephalinBgeeganglionic eminence1.00infobox
MicrocephalinBgeeAchilles tendon1.00infobox
MicrocephalinBgeeventricular zone1.00infobox
MicrocephalinBgeebone marrow cell1.00infobox
MicrocephalinBgeegastrocnemius muscle1.00infobox
MicrocephalinBgeemuscle of thigh1.00infobox
MicrocephalinBgeepopliteal artery1.00infobox
MicrocephalinBgeetibial arteries1.00infobox
MicrocephalinBgeetesticle1.00infobox
MicrocephalinBgeezygote1.00infobox
MicrocephalinBgeehand1.00infobox
MicrocephalinBgeetail of embryo1.00infobox
MicrocephalinBgeeprimary oocyte1.00infobox
MicrocephalinBgeegenital tubercle1.00infobox
MicrocephalinBgeespermatocyte1.00infobox
MicrocephalinBgeeprimitive streak1.00infobox
MicrocephalinBgeeepiblast1.00infobox
MicrocephalinBgeeotic vesicle1.00infobox
MicrocephalinBioGPSn/a1.00infobox
MicrocephalinChr.Chromosome 8 (human)1.00infobox
MicrocephalinChr.Chromosome 8 (mouse)1.00infobox
MicrocephalinDatabasesNCBI: entry; OMA: entry1.00infobox
MicrocephalinEnd6,648,508 bp1.00infobox
MicrocephalinEnd18,853,205 bp1.00infobox
MicrocephalinEnsemblENSG00000147316 ENSG000002852621.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Microcephalin bring nearby vocabulary together. In this analysis, examples include Location, Chromosome and Bp. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • brain
    • Mcph1
    • Microcephalin
    • Gene
    • Development
    • Structure
    • Microcephaly
    • Genes
    • Expressed
    • Expression
    • Fetal
    • Primary
    • Al
  • expression in the brain
    • Location
    • Mcph1
    • Chromosome
    • External
    • Bp
    • Chr
    • Human
    • Microcephalin
    • Gene
    • Fetal
    • Mouse
    • Primary
  • gene
    • Human
    • Mcph1
    • Microcephalin
    • Brain
    • Location
    • Chromosome
    • Bp
    • Chr
    • Another
    • Expressed
    • Expression
    • Fetal
  • microcephaly
    • Another
    • Normal
    • Similarly
    • Studied
    • Cdk5rap2
    • Females
    • Structure
    • Mental
    • Mutations
    • Primary
    • Al
    • Aspm
  • other mcph genes
    • Genes
    • Mcph
    • Studies
    • External
    • Structure
    • Mcph1
    • Location
    • Chromosome
    • Al
    • Bp
    • Chr
    • Et
  • structure
    • External
    • Genes
    • Expression
    • Studied
    • Al
    • Et
    • Location
    • Mcph
    • Variants
    • Chromosome
    • Later
    • Bp
  • cdk5rap2
    • Females
    • Structure
    • Microcephaly
    • Normal
    • Similarly
    • Studied
    • Al
    • Et
    • Genetic
    • Variants
    • Later
    • Mcph1
  • fetal
    • Development
    • Microcephalin
    • Expression
    • Mouse
    • Primary
    • Location
    • Gene
    • Band
    • Brain
    • Chromosome
    • Bp
    • Chr

Connections between topic areas Semantic bridges

For Microcephalin, one of the stronger structural bridges in this analysis connects Microcephalin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Microcephalin — Overview · splits 39 ⟂ 12
Microcephalin — Evolution · splits 42 ⟂ 9
Microcephalin — Other MCPH genes · splits 42 ⟂ 9
Microcephalin — Controversy · splits 44 ⟂ 7
Microcephalin — Expression in the brain · splits 45 ⟂ 6
Microcephalin — Structure · splits 46 ⟂ 5

Map overview Semantic statistics

Microcephalin

Nodes51
Edges50
Triples89
Avg. degree1.96
Density0.039216
Components1

Source & methodology

TTTA analyzes the structure around Microcephalin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Evolution & Other MCPH genes, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Microcephalin · EN edition · Analysis: TopicsToTalkAbout

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