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Microcephalin: Research, Other MCPH genes & Evolution

Microcephalin (MCPH1) is a gene that is expressed during fetal brain development. Certain mutations in MCPH1, when homozygous, cause primary microcephaly—a severely diminished brain. Hence, it has been assumed that variants have a role in brain development. However, in normal individuals no effect on mental ability or behavior has yet been demonstrated…

Language: English [EN]

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Microcephalin topic overview

The analysis highlights Research, Other MCPH genes and Evolution as prominent areas in the source structure around Microcephalin.

Related topics: 44
Source areas: 7
Connected nodes: 51
Extracted relationships: 92
Concept neighborhoods: 16
Bridge connections: 51

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics

Other MCPH genes · 9 topics

Evolution · 8 topics

Controversy · 6 topics

Expression in the brain · 5 topics

Structure · 4 topics

Research studies · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: MCPH1, BRIT1, MCT, microcephalin 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM
Band: 8p23.1 · 8|8 A1.3
Bgee: secondary oocyte · ganglionic eminence · Achilles tendon · ventricular zone · bone marrow cell
BioGPS: n/a
Chr.: Chromosome 8 (human) · Chromosome 8 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Less obvious directions

Research studies

Rhesus monkeys

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene
Mutations Mutation
Homozygous
Microcephaly
Brain Human brain
Mental Mind
Behavior
ASPM ASPM (gene)
MRI
Cortical Cerebral cortex
CDK5RAP2

Structure

Expression in the brain

Fetal Fetus
Forebrain
Lateral ventricles
Cells Cell (biology)
Neurons Neuron

Evolution

Sub-Saharan Africa
Selective sweep
Evolutionary pressures Evolutionary pressure
Tonal languages Tonal language
Chromosomes Chromosome
IQ
Admixture between modern humans and extinct Homo spp Archaic human admixture with modern humans
Neanderthals Neanderthal

Controversy

John Derbyshire
Richard Lewontin
Bruce Lahn
Genetic association studies Genome-wide association study
Upstream and downstream Upstream and downstream (DNA)
Regulatory elements

Other MCPH genes

WDR62
KNL1
CENPJ
STIL
CEP135
CEP152
ZNF335 ZNF335?action=edit&redlink=1
PHC1
CDK6

Research studies

Rhesus monkeys Rhesus monkey

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Microcephalin connects Entity context

The extracted context around Microcephalin shows recurring relationship patterns in the source. For example, Microcephalin → Achilles tendon, bone marrow cell, epiblast, ganglionic eminence, gastrocnemius muscle, genital tubercle, hand, muscle of thigh, otic vesicle, popliteal artery, primary oocyte, primitive streak, secondary oocyte, spermatocyte, tail of embryo, testicle, tibial arteries, ventricular zone, zygote Another extracted example is Microcephalin → bone development, cerebral cortex development, cytoplasm, cytoskeleton, establishment of mitotic spindle orientation, identical protein binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, nucleoplasm, protein binding, protein localization to centrosome, regulation of centrosome cycle, regulation of chromosome condensation, regulation of gene expression, regulation of inflammatory response, regulation of kinase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

Microcephalin

Top relations

Bgee · 19

Microcephalin → Achilles tendon, bone marrow cell, epiblast, ganglionic eminence, gastrocnemius muscle, genital tubercle, hand, muscle of thigh, otic vesicle, popliteal artery, primary oocyte, primitive streak, secondary oocyte, spermatocyte, tail of embryo, testicle, tibial arteries, ventricular zone, zygote

RNA expression pattern · 19

Gene ontology · 17

Microcephalin → bone development, cerebral cortex development, cytoplasm, cytoskeleton, establishment of mitotic spindle orientation, identical protein binding, microtubule organizing center, negative regulation of transcription by RNA polymerase II, neuronal stem cell population maintenance, nucleoplasm, protein binding, protein localization to centrosome, regulation of centrosome cycle, regulation of chromosome condensation, regulation of gene expression, regulation of inflammatory response, regulation of kinase activity

related to Evolution · 10

Microcephalin → ASPM, Homo, However, IQ, MCPH1, Neanderthal, Sub-Saharan Africa, The, This, While Neanderthals

related to Structure · 4

Microcephalin → C-terminal BRCT, InterPro, IPR022047, N-terminal BRCT

Band · 2

Microcephalin → 8p23.1, 8|8 A1.3

Chr. · 2

Microcephalin → Chromosome 8 (human), Chromosome 8 (mouse)

End · 2

Microcephalin → 18,853,205 bp, 6,648,508 bp

Aliases · 1

Microcephalin → MCPH1, BRIT1, MCT, microcephalin 1

Available structures · 1

Microcephalin → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mcph1 brain gene bp human microcephaly chr band chromosome genes studies development variants however aspm cdk5rap2 structure expressed location may

Microcephalin relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around Microcephalin. Examples in this analysis include Microcephalin → Aliases → MCPH1, BRIT1, MCT, microcephalin 1 and Microcephalin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Microcephalin	Aliases	MCPH1, BRIT1, MCT, microcephalin 1	1.00	infobox
Microcephalin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3T1N, 3SHT, 2WT8, 3SHV, 3U3Z, 3KTF, 3PA6, 3SZM	1.00	infobox
Microcephalin	Band	8p23.1	1.00	infobox
Microcephalin	Band	8\|8 A1.3	1.00	infobox
Microcephalin	Bgee	secondary oocyte	1.00	infobox
Microcephalin	Bgee	ganglionic eminence	1.00	infobox
Microcephalin	Bgee	Achilles tendon	1.00	infobox
Microcephalin	Bgee	ventricular zone	1.00	infobox
Microcephalin	Bgee	bone marrow cell	1.00	infobox
Microcephalin	Bgee	gastrocnemius muscle	1.00	infobox
Microcephalin	Bgee	muscle of thigh	1.00	infobox
Microcephalin	Bgee	popliteal artery	1.00	infobox
Microcephalin	Bgee	tibial arteries	1.00	infobox
Microcephalin	Bgee	testicle	1.00	infobox
Microcephalin	Bgee	zygote	1.00	infobox
Microcephalin	Bgee	hand	1.00	infobox
Microcephalin	Bgee	tail of embryo	1.00	infobox
Microcephalin	Bgee	primary oocyte	1.00	infobox
Microcephalin	Bgee	genital tubercle	1.00	infobox
Microcephalin	Bgee	spermatocyte	1.00	infobox
Microcephalin	Bgee	primitive streak	1.00	infobox
Microcephalin	Bgee	epiblast	1.00	infobox
Microcephalin	Bgee	otic vesicle	1.00	infobox
Microcephalin	BioGPS	n/a	1.00	infobox
Microcephalin	Chr.	Chromosome 8 (human)	1.00	infobox
Microcephalin	Chr.	Chromosome 8 (mouse)	1.00	infobox
Microcephalin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Microcephalin	End	6,648,508 bp	1.00	infobox
Microcephalin	End	18,853,205 bp	1.00	infobox
Microcephalin	Ensembl	ENSG00000147316 ENSG00000285262	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Microcephalin bring nearby vocabulary together. In this analysis, examples include Location, Chromosome and Bp. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

gene
- Human
- Mcph1
- Microcephalin
- Brain
- Location
- Chromosome
- Bp
- Chr
- Another
- Expressed
- Expression
- Fetal
brain
- Mcph1
- Microcephalin
- Gene
- Development
- Structure
- Microcephaly
- Genes
- Expressed
- Expression
- Fetal
- Primary
- Al
expression in the brain
- Location
- Mcph1
- Chromosome
- External
- Bp
- Chr
- Human
- Microcephalin
- Gene
- Fetal
- Mouse
- Primary
microcephaly
- Another
- Normal
- Similarly
- Studied
- Cdk5rap2
- Females
- However
- Structure
- Mental
- Mutations
- Primary
- Al
other mcph genes
- Genes
- Mcph
- Studies
- External
- Structure
- Mcph1
- Location
- Chromosome
- Al
- Bp
- Chr
- Et
structure
- External
- Genes
- Expression
- Studied
- Al
- Et
- Location
- Mcph
- Variants
- Chromosome
- Later
- Bp
cdk5rap2
- Females
- Structure
- Microcephaly
- Normal
- Similarly
- Studied
- Al
- Et
- Genetic
- However
- Variants
- Later
fetal
- Development
- Microcephalin
- Expression
- Mouse
- Primary
- Location
- Gene
- Band
- Brain
- Chromosome
- Bp
- Chr

Connections between topic areas Semantic bridges

For Microcephalin, one of the stronger structural bridges in this analysis connects Microcephalin with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Microcephalin — Overview · splits 40 ⟂ 12

Microcephalin — Other MCPH genes · splits 42 ⟂ 10

Microcephalin — Evolution · splits 43 ⟂ 9

Microcephalin — Controversy · splits 45 ⟂ 7

Microcephalin — Expression in the brain · splits 46 ⟂ 6

Microcephalin — Structure · splits 47 ⟂ 5

Map overview Semantic statistics

Microcephalin

Nodes52

Edges51

Triples92

Avg. degree1.96

Density0.038462

Components1

Source & methodology

TTTA analyzes the structure around Microcephalin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research, Other MCPH genes & Evolution, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Microcephalin · EN edition · Analysis: TopicsToTalkAbout

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