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Massively parallel sequencing: History & Technology

Massively parallel sequencing (MPS) is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation sequencing. Some of these technologies emerged between 1993 and 1998 and have been commercially available since 2005. These…

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Massively parallel sequencing topic overview

The analysis highlights History and Technology as prominent areas in the source structure around Massively parallel sequencing.

Related topics
54
Source areas
5
Connected nodes
59
Extracted relationships
8
Related term clusters
28
Bridge connections
59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

History · 24 topics
Sequencing approaches · 10 topics
Template preparation methods for NGS · 9 topics
Overview · 6 topics
NGS platforms · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

NGS platforms

Template preparation methods for NGS

Sequencing approaches

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Advanced semantic analysis

How Massively parallel sequencing connects Entity context

The extracted context around Massively parallel sequencing shows recurring relationship patterns in the source. For example, Massively parallel sequencing → DNA, Illumina, IonTorrent, MGI, PacBio, SBS. Use these groups to spot repeated connection types before inspecting the individual relationships.

Massively parallel sequencing

Top relations

related to Sequencing by synthesis · 6
Massively parallel sequencing → DNA, Illumina, IonTorrent, MGI, PacBio, SBS

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sequencing dna illumina single amplification ngs polymerase templates synthesis nucleotides solid template platforms 454 incorporation run nucleotide biosciences used approach

Massively parallel sequencing relationships Subject–Predicate–Object triples

TTTA extracted 8 structured relationships around Massively parallel sequencing. Examples in this analysis include used by Illumina/Solexa → instance of → Sequencing by reversible terminator chemistry can be a four-colour cycle and Massively parallel sequencing → related to Sequencing by synthesis → SBS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
used by Illumina/Solexainstance ofSequencing by reversible terminator chemistry can be a four-colour cycle0.80text
or a one-colour cycle such as used by Helicos BioSciencesinstance ofSequencing by reversible terminator chemistry can be a four-colour cycle0.80text
Massively parallel sequencingrelated to Sequencing by synthesisSBS0.60section
Massively parallel sequencingrelated to Sequencing by synthesisDNA0.60section
Massively parallel sequencingrelated to Sequencing by synthesisPacBio0.60section
Massively parallel sequencingrelated to Sequencing by synthesisIonTorrent0.60section
Massively parallel sequencingrelated to Sequencing by synthesisIllumina0.60section
Massively parallel sequencingrelated to Sequencing by synthesisMGI0.60section

Related concept clusters Related term clusters

The concept neighborhoods around Massively parallel sequencing bring nearby vocabulary together. In this analysis, examples include Parallel, Amplified and Spatially. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Massively parallel sequencing
    • Parallel
    • Amplified
    • Spatially
    • Run
    • Synthesis
    • Templates
    • Per
    • Technology
    • Amplification
    • Genome
    • Approaches
    • Nucleotides
  • rolling circle amplification
    • Dna
    • Pcr
    • Single
    • Flow
    • Using
    • Nucleotides
    • Template
    • Sequencing
    • Cell
    • Methods
    • Nucleotide
    • Surface
  • massively parallel sequencing
    • Parallel
    • Amplified
    • Illumina
    • Spatially
    • Run
    • Platforms
    • Synthesis
    • Templates
    • Per
    • Technology
    • Amplification
    • Genome
  • dna sequencing
    • Single
    • Polymerase
    • Amplification
    • Illumina
    • Sequencing
    • Nucleotides
    • Templates
    • Ngs
    • Run
    • Synthesis
    • Incorporation
    • Platforms
  • dna
    • Single
    • Polymerase
    • Amplification
    • Sequencing
    • Nucleotides
    • Templates
    • Ngs
    • Synthesis
    • Incorporation
    • Molecules
    • Using
    • Amplified
  • sanger sequencing
    • Illumina
    • Run
    • Platforms
    • Synthesis
    • Per
    • Technology
    • Amplification
    • Genome
    • Nucleotides
    • Flow
    • Biosciences
    • Polymerase
  • genome sequencing costs below $1000
    • Per
    • Illumina
    • Run
    • Platforms
    • Synthesis
    • Technology
    • Amplification
    • Genome
    • Sequencing
    • Nucleotides
    • Technologies
    • Flow
  • sequencing by synthesis (sbs)
    • Illumina
    • Incorporation
    • Polymerase
    • Run
    • Platforms
    • Synthesis
    • Nucleotide
    • Sequence
    • Per
    • Technology
    • Amplification
    • Template

Connections between topic areas Semantic bridges

For Massively parallel sequencing, one of the stronger structural bridges in this analysis connects Massively parallel sequencing with History. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Massively parallel sequencing — History · splits 35 ⟂ 25
Massively parallel sequencing — Sequencing approaches · splits 49 ⟂ 11
Massively parallel sequencing — Template preparation methods for NGS · splits 50 ⟂ 10
Massively parallel sequencing — Overview · splits 53 ⟂ 7
Massively parallel sequencing — NGS platforms · splits 54 ⟂ 6

Map overview Semantic statistics

Massively parallel sequencing

Nodes60
Edges59
Triples8
Avg. degree1.97
Density0.033333
Components1

Source & methodology

TTTA analyzes the structure around Massively parallel sequencing to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Technology, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Massively parallel sequencing · EN edition · Analysis: TopicsToTalkAbout

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