Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
Mitogen-activated protein kinase 12 (MAP kinase 12), also known as extracellular signal-regulated kinase 6 (ERK6) or stress-activated protein kinase 3 (SAPK3), is an enzyme that in humans is encoded by the MAPK12 gene.
The analysis highlights Function and Overview as prominent areas in the source structure around MAPK12.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around MAPK12 shows recurring relationship patterns in the source. For example, MAPK12 → ATP binding, cell cycle, cellular response to organic substance, cytoplasm, cytosol, DNA damage induced protein phosphorylation, intracellular signal transduction, kinase activity, magnesium ion binding, MAP kinase activity, MAPK cascade, metal ion binding, mitochondrion, muscle organ development, myoblast differentiation, negative regulation of cell cycle, nucleoplasm, nucleotide binding, nucleus, peptidyl-serine phosphorylation Another extracted example is MAPK12 → ankle, anterior pituitary, biceps brachii, digastric muscle, gastrocnemius muscle, glutes, medial head of gastrocnemius muscle, muscle of thigh, right hemisphere of cerebellum, Skeletal muscle tissue of rectus abdominis, sternocleidomastoid muscle, temporal muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp protein gene chr human band kinase chromosome 22 mitogen-activated map location enzyme mouse 12 erk6 sapk3 function extracellular stress-activated
TTTA extracted 89 structured relationships around MAPK12. Examples in this analysis include MAPK12 → 2.7.11.24 → ↗ and MAPK12 → Aliases → MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| MAPK12 | 2.7.11.24 | ↗ | 1.00 | infobox |
| MAPK12 | Aliases | MAPK12, ERK3, ERK6, P38GAMMA, PRKM12, SAPK-3, SAPK3, ERK-6, MAPK 12, mitogen-activated protein kinase 12 | 1.00 | infobox |
| MAPK12 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CM8, 4QUM | 1.00 | infobox |
| MAPK12 | Band | 22q13.33 | 1.00 | infobox |
| MAPK12 | Band | 15|15 E3 | 1.00 | infobox |
| MAPK12 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| MAPK12 | Bgee | muscle of thigh | 1.00 | infobox |
| MAPK12 | Bgee | triceps brachii muscle | 1.00 | infobox |
| MAPK12 | Bgee | vastus lateralis muscle | 1.00 | infobox |
| MAPK12 | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| MAPK12 | Bgee | thoracic diaphragm | 1.00 | infobox |
| MAPK12 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| MAPK12 | Bgee | anterior pituitary | 1.00 | infobox |
| MAPK12 | Bgee | glutes | 1.00 | infobox |
| MAPK12 | Bgee | biceps brachii | 1.00 | infobox |
| MAPK12 | Bgee | temporal muscle | 1.00 | infobox |
| MAPK12 | Bgee | ankle | 1.00 | infobox |
| MAPK12 | Bgee | tibialis anterior muscle | 1.00 | infobox |
| MAPK12 | Bgee | digastric muscle | 1.00 | infobox |
| MAPK12 | Bgee | sternocleidomastoid muscle | 1.00 | infobox |
| MAPK12 | Bgee | medial head of gastrocnemius muscle | 1.00 | infobox |
| MAPK12 | BioGPS | n/a | 1.00 | infobox |
| MAPK12 | Chr. | Chromosome 22 (human) | 1.00 | infobox |
| MAPK12 | Chr. | Chromosome 15 (mouse) | 1.00 | infobox |
| MAPK12 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| MAPK12 | End | 50,261,716 bp | 1.00 | infobox |
| MAPK12 | End | 89,024,906 bp | 1.00 | infobox |
| MAPK12 | Ensembl | ENSG00000188130 | 1.00 | infobox |
| MAPK12 | Entrez | 6300 | 1.00 | infobox |
| MAPK12 | Enzyme activity | Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.24↗↗↗↗ | 1.00 | infobox |
The concept neighborhoods around MAPK12 bring nearby vocabulary together. In this analysis, examples include Mitogen-activated, Activity and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For MAPK12, one of the stronger structural bridges in this analysis connects MAPK12 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around MAPK12 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — MAPK12 · EN edition · Analysis: TopicsToTalkAbout