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Macitentan

Macitentan, sold under the brand name Opsumit, is an endothelin receptor antagonist developed by Actelion and approved for the treatment of pulmonary arterial hypertension (PAH). Macitentan is a dual endothelin receptor antagonist, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a…

Art, Pharmacokinetics & Adverse effects

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C02KX04 (WHO)
CAS Number
441798-33-0
ChEBI
CHEBI:76607
ChEMBL
ChEMBL2103873

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Overview

Adverse effects

Mechanism of action

Pharmacokinetics

Advanced semantic analysis

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Map overview Semantic statistics

Macitentan

Nodes20
Edges19
Triples49
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

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Macitentan

Top relations

related to Pharmacokinetics · 10
Macitentan → ACT-132577, Although, AUC, Both, Co-administration, CYP3A4, ET, It, Its, This
related to Role of macitentan · 9
Macitentan → Blocking, Endothelin, ET, ET-1, ET1-dependent, ETA, ETB, PAH, The
related to Experimental pharmacokinetics · 4
Macitentan → Bosentan, ET, Its, This
Legal status · 3
Macitentan → AU: S4 (Prescription only), EU: Rx-only, US: ℞-only
3D model (JSmol) · 1
Macitentan → Interactive image
AHFS/Drugs.com · 1
Macitentan → Monograph
ATC code · 1
Macitentan → C02KX04 (WHO)
CAS Number · 1
Macitentan → 441798-33-0
ChEBI · 1
Macitentan → CHEBI:76607
ChEMBL · 1
Macitentan → ChEMBL2103873

Important terminology Word statistics

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Important terminology

endothelin et receptor receptors eta etb arterial cells et-1 pulmonary antagonist smooth muscle half-life plasma pah compared approved name opsumit

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Macitentan3D model (JSmol)Interactive image1.00infobox
MacitentanAHFS/Drugs.comMonograph1.00infobox
MacitentanATC codeC02KX04 (WHO)1.00infobox
MacitentanCAS Number441798-33-01.00infobox
MacitentanChEBICHEBI:766071.00infobox
MacitentanChEMBLChEMBL21038731.00infobox
MacitentanChemSpider131349601.00infobox
MacitentanCompTox Dashboard (EPA)DTXSID501960631.00infobox
MacitentanDrugBankDB089321.00infobox
MacitentanExcretion2/3 urine, 1/3 faeces1.00infobox
MacitentanFormulaC19H20Br2N6O4S1.00infobox
MacitentanKEGGD101351.00infobox
MacitentanLegal statusAU: S4 (Prescription only)1.00infobox
MacitentanLegal statusUS: ℞-only1.00infobox
MacitentanLegal statusEU: Rx-only1.00infobox
MacitentanLicense dataUS DailyMed: Macitentan1.00infobox
MacitentanMedlinePlusa6150331.00infobox
MacitentanMetabolismHydrolysis, oxidation (CYP3A4)1.00infobox
MacitentanMolar mass588.28 g·mol−11.00infobox
MacitentanOther namesACT-0649921.00infobox
MacitentanPregnancy categoryAU: X (High risk)1.00infobox
MacitentanPubChem CID160046921.00infobox
MacitentanRoutes of administrationBy mouth1.00infobox
MacitentanTrade namesOpsumit1.00infobox
MacitentanUNIIZ9K9Y9WMVL1.00infobox
Macitentanis adual endothelin receptor antagonist0.90text

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