Macitentan

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Macitentan topic overview

The analysis highlights Art, Pharmacokinetics and Adverse effects as prominent areas in the source structure around Macitentan.

Related topics: 15
Source areas: 4
Connected nodes: 19
Extracted relationships: 49
Concept neighborhoods: 11
Bridge connections: 19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics

Pharmacokinetics · 6 topics

Adverse effects · 2 topics

Mechanism of action · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol): Interactive image
AHFS/Drugs.com: Monograph
ATC code: C02KX04 (WHO)
CAS Number: 441798-33-0
ChEBI: CHEBI:76607
ChEMBL: ChEMBL2103873

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Endothelin receptor antagonist
Actelion
Pulmonary arterial hypertension
Endothelin
ETA Endothelin receptor type A
ETB Endothelin receptor type B

Adverse effects

Mechanism of action

Gαq

Pharmacokinetics

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Macitentan connects Entity context

The extracted context around Macitentan shows recurring relationship patterns in the source. For example, Macitentan → ACT-132577, Although, AUC, Both, Co-administration, CYP3A4, ET, It, Its, This Another extracted example is Macitentan → Blocking, Endothelin, ET, ET-1, ET1-dependent, ETA, ETB, PAH, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Pharmacokinetics · 10

Macitentan → ACT-132577, Although, AUC, Both, Co-administration, CYP3A4, ET, It, Its, This

related to Role of macitentan · 9

Macitentan → Blocking, Endothelin, ET, ET-1, ET1-dependent, ETA, ETB, PAH, The

related to Experimental pharmacokinetics · 4

Macitentan → Bosentan, ET, Its, This

Legal status · 3

Macitentan → AU: S4 (Prescription only), EU: Rx-only, US: ℞-only

3D model (JSmol) · 1

Macitentan → Interactive image

AHFS/Drugs.com · 1

Macitentan → Monograph

ATC code · 1

Macitentan → C02KX04 (WHO)

CAS Number · 1

Macitentan → 441798-33-0

ChEBI · 1

Macitentan → CHEBI:76607

ChEMBL · 1

Macitentan → ChEMBL2103873

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

endothelin et receptor receptors eta etb arterial cells et-1 pulmonary antagonist smooth muscle half-life plasma pah compared approved name opsumit

Macitentan relationships Subject–Predicate–Object triples

TTTA extracted 49 structured relationships around Macitentan. Examples in this analysis include Macitentan → 3D model (JSmol) → Interactive image and Macitentan → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Macitentan	3D model (JSmol)	Interactive image	1.00	infobox
Macitentan	AHFS/Drugs.com	Monograph	1.00	infobox
Macitentan	ATC code	C02KX04 (WHO)	1.00	infobox
Macitentan	CAS Number	441798-33-0	1.00	infobox
Macitentan	ChEBI	CHEBI:76607	1.00	infobox
Macitentan	ChEMBL	ChEMBL2103873	1.00	infobox
Macitentan	ChemSpider	13134960	1.00	infobox
Macitentan	CompTox Dashboard (EPA)	DTXSID50196063	1.00	infobox
Macitentan	DrugBank	DB08932	1.00	infobox
Macitentan	Excretion	2/3 urine, 1/3 faeces	1.00	infobox
Macitentan	Formula	C19H20Br2N6O4S	1.00	infobox
Macitentan	KEGG	D10135	1.00	infobox
Macitentan	Legal status	AU: S4 (Prescription only)	1.00	infobox
Macitentan	Legal status	US: ℞-only	1.00	infobox
Macitentan	Legal status	EU: Rx-only	1.00	infobox
Macitentan	License data	US DailyMed: Macitentan	1.00	infobox
Macitentan	MedlinePlus	a615033	1.00	infobox
Macitentan	Metabolism	Hydrolysis, oxidation (CYP3A4)	1.00	infobox
Macitentan	Molar mass	588.28 g·mol−1	1.00	infobox
Macitentan	Other names	ACT-064992	1.00	infobox
Macitentan	Pregnancy category	AU: X (High risk)	1.00	infobox
Macitentan	PubChem CID	16004692	1.00	infobox
Macitentan	Routes of administration	By mouth	1.00	infobox
Macitentan	Trade names	Opsumit	1.00	infobox
Macitentan	UNII	Z9K9Y9WMVL	1.00	infobox
Macitentan	is a	dual endothelin receptor antagonist	0.90	text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Macitentan bring nearby vocabulary together. In this analysis, examples include Receptor, Receptors and Et. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Macitentan
- Receptor
- Receptors
- Et
- Antagonist
- Approximately
- Half-life
- Plasma
- Endothelin
- Approved
- Aprocitentan
- Cyp3a4
- High
macitentan
- Receptor
- Receptors
- Et
- Antagonist
- Approximately
- Half-life
- Plasma
- Endothelin
- Approved
- Aprocitentan
- Cyp3a4
- High
endothelin receptor antagonist
- Receptor
- Eta
- Etb
- Actelion
- Hypertension
- Name
- Opsumit
- Subtypes
- Treatment
- Two
- Antagonist
- Endothelin
endothelin
- Hypertension
- Name
- Opsumit
- Receptor
- Subtypes
- Two
- Antagonist
- Pulmonary
- Eta
- Etb
- Arterial
- Cells
pulmonary arterial hypertension
- Muscle
- Pulmonary
- Smooth
- Cells
- Treatment
- Pah
- Hypertension
- Name
- Opsumit
- Receptor
- Endothelin
- Subtype
eta
- Etb
- Subtype
- Subtypes
- Two
- Receptor
- Cells
- Increased
- Treatment
- Compared
- Pah
- Muscle
- Pulmonary
etb
- Subtype
- Subtypes
- Two
- Receptor
- Cells
- Increased
- Treatment
- Compared
- Pah
- Muscle
- Pulmonary
- Smooth
actelion
- Approved
- Hypertension
- Name
- Opsumit
- Treatment
- Antagonist
- Pah
- Pulmonary
- Arterial
- Endothelin
- Receptor
- Macitentan

Connections between topic areas Semantic bridges

For Macitentan, one of the stronger structural bridges in this analysis connects Macitentan with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Macitentan — Overview · splits 13 ⟂ 7

Macitentan — Pharmacokinetics · splits 13 ⟂ 7

Macitentan — Adverse effects · splits 17 ⟂ 3

Map overview Semantic statistics

Macitentan

Nodes20

Edges19

Triples49

Avg. degree1.9

Density0.1

Components1

Source & methodology

TTTA analyzes the structure around Macitentan to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Pharmacokinetics & Adverse effects, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Macitentan · EN edition · Analysis: TopicsToTalkAbout