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N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene. The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around KMT5A.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around KMT5A shows recurring relationship patterns in the source. For example, KMT5A → cell cycle, cell division, chromatin organization, chromosome, cytosol, histone H4-K20 methylation, histone lysine methylation, histone methyltransferase activity (H4-K20 specific), histone-lysine N-methyltransferase activity, lysine N-methyltransferase activity, methylation, methyltransferase activity, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, p53 binding, peptidyl-lysine monomethylation, protein binding, protein-lysine N-methyltransferase activity Another extracted example is KMT5A → Achilles tendon, ascending aorta, body of pancreas, Descending thoracic aorta, gastrula, genital tubercle, granulocyte, knee joint, lip, muscle of thigh, popliteal artery, pyloric antrum, right coronary artery, right lobe of thyroid gland, sural nerve, tail of embryo, thoracic aorta, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
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lysine bp enzyme chr histone human chromosome band methyltransferase gene 12 methyl group residue location h4 position 20 mouse search
TTTA extracted 91 structured relationships around KMT5A. Examples in this analysis include KMT5A → 2.1.1.354 → ↗ and KMT5A → Aliases → KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| KMT5A | 2.1.1.354 | ↗ | 1.00 | infobox |
| KMT5A | 2.1.1.361 | ↗ | 1.00 | infobox |
| KMT5A | Aliases | KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07 | 1.00 | infobox |
| KMT5A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2 | 1.00 | infobox |
| KMT5A | Band | 12q24.31 | 1.00 | infobox |
| KMT5A | Band | 5|5 F | 1.00 | infobox |
| KMT5A | Bgee | sural nerve | 1.00 | infobox |
| KMT5A | Bgee | ventricular zone | 1.00 | infobox |
| KMT5A | Bgee | right coronary artery | 1.00 | infobox |
| KMT5A | Bgee | thoracic aorta | 1.00 | infobox |
| KMT5A | Bgee | ascending aorta | 1.00 | infobox |
| KMT5A | Bgee | Descending thoracic aorta | 1.00 | infobox |
| KMT5A | Bgee | Achilles tendon | 1.00 | infobox |
| KMT5A | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| KMT5A | Bgee | body of pancreas | 1.00 | infobox |
| KMT5A | Bgee | popliteal artery | 1.00 | infobox |
| KMT5A | Bgee | tail of embryo | 1.00 | infobox |
| KMT5A | Bgee | genital tubercle | 1.00 | infobox |
| KMT5A | Bgee | gastrula | 1.00 | infobox |
| KMT5A | Bgee | granulocyte | 1.00 | infobox |
| KMT5A | Bgee | muscle of thigh | 1.00 | infobox |
| KMT5A | Bgee | pyloric antrum | 1.00 | infobox |
| KMT5A | Bgee | zygote | 1.00 | infobox |
| KMT5A | Bgee | lip | 1.00 | infobox |
| KMT5A | Bgee | knee joint | 1.00 | infobox |
| KMT5A | BioGPS | More reference expression data | 1.00 | infobox |
| KMT5A | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| KMT5A | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| KMT5A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| KMT5A | End | 123,409,353 bp | 1.00 | infobox |
The concept neighborhoods around KMT5A bring nearby vocabulary together. In this analysis, examples include Gene, Methyltransferase and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the KMT5A map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around KMT5A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — KMT5A · EN edition · Analysis: TopicsToTalkAbout