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KMT5A

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the KMT5A gene. The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. S-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue…

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KMT5A at a glance

EnzymeGeneSET domain-containing and lysine-specificMethyl groupHistone H4

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Explore the main themes, entities and connections around KMT5A. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Key facts & relationships

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2.1.1.354
↗
2.1.1.361
↗
Aliases
KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2
Band
12q24.31 · 5|5 F
Bgee
sural nerve · ventricular zone · right coronary artery · thoracic aorta · ascending aorta

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Overview

Advanced semantic analysis

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KMT5A

Top relations

Gene ontology · 26
KMT5A → cell cycle, cell division, chromatin organization, chromosome, cytosol, histone H4-K20 methylation, histone lysine methylation, histone methyltransferase activity (H4-K20 specific), histone-lysine N-methyltransferase activity, lysine N-methyltransferase activity, methylation, methyltransferase activity, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleoplasm, nucleus, p53 binding, peptidyl-lysine monomethylation, protein binding, protein-lysine N-methyltransferase activity
Bgee · 19
KMT5A → Achilles tendon, ascending aorta, body of pancreas, Descending thoracic aorta, gastrula, genital tubercle, granulocyte, knee joint, lip, muscle of thigh, popliteal artery, pyloric antrum, right coronary artery, right lobe of thyroid gland, sural nerve, tail of embryo, thoracic aorta, ventricular zone, zygote
RNA expression pattern · 19
KMT5A → Achilles tendon, ascending aorta, body of pancreas, Descending thoracic aorta, gastrula, genital tubercle, granulocyte, knee joint, lip, muscle of thigh, popliteal artery, pyloric antrum, right coronary artery, right lobe of thyroid gland, sural nerve, tail of embryo, thoracic aorta, ventricular zone, zygote
Band · 2
KMT5A → 12q24.31, 5|5 F
Chr. · 2
KMT5A → Chromosome 12 (human), Chromosome 5 (mouse)
End · 2
KMT5A → 123,409,353 bp, 124,600,371 bp
2.1.1.354 · 1
KMT5A → ↗
2.1.1.361 · 1
KMT5A → ↗
Aliases · 1
KMT5A → KMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET07
Available structures · 1
KMT5A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ2

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Important terminology

lysine bp enzyme chr histone human chromosome band methyltransferase gene 12 methyl group residue location h4 position 20 mouse search

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
KMT5A2.1.1.354↗1.00infobox
KMT5A2.1.1.361↗1.00infobox
KMT5AAliasesKMT5A, PR-Set7, SET07, SET8, SETD8, lysine methyltransferase 5A, PR/SET071.00infobox
KMT5AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZKK, 2BQZ, 3F9W, 3F9X, 3F9Y, 3F9Z, 4IJ8, 5HQ21.00infobox
KMT5ABand12q24.311.00infobox
KMT5ABand5|5 F1.00infobox
KMT5ABgeesural nerve1.00infobox
KMT5ABgeeventricular zone1.00infobox
KMT5ABgeeright coronary artery1.00infobox
KMT5ABgeethoracic aorta1.00infobox
KMT5ABgeeascending aorta1.00infobox
KMT5ABgeeDescending thoracic aorta1.00infobox
KMT5ABgeeAchilles tendon1.00infobox
KMT5ABgeeright lobe of thyroid gland1.00infobox
KMT5ABgeebody of pancreas1.00infobox
KMT5ABgeepopliteal artery1.00infobox
KMT5ABgeetail of embryo1.00infobox
KMT5ABgeegenital tubercle1.00infobox
KMT5ABgeegastrula1.00infobox
KMT5ABgeegranulocyte1.00infobox
KMT5ABgeemuscle of thigh1.00infobox
KMT5ABgeepyloric antrum1.00infobox
KMT5ABgeezygote1.00infobox
KMT5ABgeelip1.00infobox
KMT5ABgeeknee joint1.00infobox
KMT5ABioGPSMore reference expression data1.00infobox
KMT5AChr.Chromosome 12 (human)1.00infobox
KMT5AChr.Chromosome 5 (mouse)1.00infobox
KMT5ADatabasesNCBI: entry; OMA: entry1.00infobox
KMT5AEnd123,409,353 bp1.00infobox

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    KMT5A

    Nodes11
    Edges10
    Triples91
    Avg. degree1.82
    Density0.181818
    Components1
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