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Pembrolizumab

Pembrolizumab, sold under the brand name Keytruda, is a humanized monoclonal antibody, more specifically a PD-1 inhibitor, used in cancer immunotherapy to treat many types of cancer. It is administered by slow intravenous injection.

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AHFS/Drugs.com
Monograph
ATC code
L01FF02 (WHO)
CAS Number
1374853-91-4
ChEMBL
ChEMBL3137343
ChemSpider
none
Drug class
Antineoplastic

Topics to explore

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Overview

Medical uses

Adverse effects

Mechanism of action

Pharmacology

Chemistry and manufacturing

History

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Pembrolizumab

Nodes119
Edges118
Triples113
Avg. degree1.98
Density0.016807
Components1

How this topic connects Entity context

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Pembrolizumab

Top relations

related to history · 27
Pembrolizumab → As, Bristol Myers Squibb, Co, Eenennaam, Foundation, Gradus Dulos, Hans, He, In, IND, Intellectual Property Owners Education, Inventors, Inventors Gregory Carven, Later, LifeArc, Martin Huber, Medical Research Council Technology, Medicine, Merck, Opdivo
related to Research · 11
Pembrolizumab → As, At ASCO, IB, II, In, June, Keynote-012, Keynote-086, May, Merck, TNBC
related to Mechanism of action · 10
Pembrolizumab → By, DNA, Many, Normally, PD-1, PD-L1, PD-L2, T-cells, This, Tumors
related to Medical uses · 9
Pembrolizumab → As, B-cell, HNSCC, Hodgkin, In, Merkel-cell, NSCLC, PD-L1, United States
related to Chemistry and manufacturing · 7
Pembrolizumab → Chinese, CHO, G4, H10-S, It, L-proline, PD-1
related to Economics · 7
Pembrolizumab → Cancer Drugs Fund, Dohme, It, Merck Sharp, NHS England, November, US
Legal status · 6
Pembrolizumab → AU: S4 (Prescription only), CA: ℞-only / Schedule D, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to External links · 5
Pembrolizumab → Medicine Medical Subject Headings, MeSH, National Cancer Institute, National Library, September
has effect · 4
Pembrolizumab → People, The, There, Type
related to Pharmacology · 3
Pembrolizumab → L/day, Since, The

Important terminology Word statistics

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Important terminology

metastatic cancer treatment fda approved us pd-l1 advanced carcinoma cell people chemotherapy tumors trial combination adults drug lung locally participants

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PembrolizumabAHFS/Drugs.comMonograph1.00infobox
PembrolizumabATC codeL01FF02 (WHO)1.00infobox
PembrolizumabCAS Number1374853-91-41.00infobox
PembrolizumabChEMBLChEMBL31373431.00infobox
PembrolizumabChemSpidernone1.00infobox
PembrolizumabDrug classAntineoplastic1.00infobox
PembrolizumabDrugBankDB090371.00infobox
PembrolizumabECHA InfoCard100.234.3701.00infobox
PembrolizumabFormulaC6534H10004N1716O2036S461.00infobox
PembrolizumabKEGGD105741.00infobox
PembrolizumabLegal statusAU: S4 (Prescription only)1.00infobox
PembrolizumabLegal statusCA: ℞-only / Schedule D1.00infobox
PembrolizumabLegal statusUK: POM (Prescription only)1.00infobox
PembrolizumabLegal statusUS: ℞-only1.00infobox
PembrolizumabLegal statusEU: Rx-only1.00infobox
PembrolizumabLegal statusIn general: ℞ (Prescription only)1.00infobox
PembrolizumabLicense dataUS DailyMed: Pembrolizumab1.00infobox
PembrolizumabMedlinePlusa6140481.00infobox
PembrolizumabMolar mass146648.64 g·mol−11.00infobox
PembrolizumabOther namesMK-3475, lambrolizumab1.00infobox
PembrolizumabPregnancy categoryAU: D1.00infobox
PembrolizumabRoutes of administrationIntravenous1.00infobox
PembrolizumabSourceHumanized (from mouse)1.00infobox
PembrolizumabTargetPD-11.00infobox
PembrolizumabTrade namesKeytruda1.00infobox
PembrolizumabTypeWhole antibody1.00infobox
PembrolizumabUNIIDPT0O3T46P1.00infobox
Pembrolizumabis aso-called tissue-agnostic drug.In the European Union0.90text

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