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IRX3: Clinical significance, Function & Discovery and name

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.

Language: English [EN]
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IRX3 topic overview

The analysis highlights Clinical significance, Function and Discovery and name as prominent areas in the source structure around IRX3.

Related topics
15
Source areas
4
Connected nodes
19
Extracted relationships
115
Related term clusters
8
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 8 topics
Function · 4 topics
Overview · 2 topics
Discovery and name · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
IRX3, IRX-1, IRXB1, iroquois homeobox 3
Band
16q12.2 · 8 C5|8 44.55 cM
Bgee
nipple · human penis · skin of arm · myocardium of left ventricle · bronchial epithelial cell
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery and name

Function

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How IRX3 connects Entity context

The extracted context around IRX3 shows recurring relationship patterns in the source. For example, IRX3 → abdominal wall, bronchial epithelial cell, calvaria, epithelium of lactiferous gland, gingival epithelium, human penis, lacrimal gland, lactiferous duct, lactiferous gland, left lung lobe, maxillary prominence, myocardium of left ventricle, nipple, right lung, right lung lobe, right ventricle, skin of arm, trachea, vestibular membrane of cochlear duct, vulva Another extracted example is IRX3 → Additionally, Brugada, Embryonically, Gja1-encoded Connexin-43, Gja5-encoded Connexin-40, Iroquois, Members, MN, NKX2-2, Nkx6, Purkinje, QRS, Sonic, Specifically, The Irx3, V0, V1, V2, V3, VCS. Use these groups to spot repeated connection types before inspecting the individual relationships.

IRX3

Top relations

Bgee · 20
IRX3 → abdominal wall, bronchial epithelial cell, calvaria, epithelium of lactiferous gland, gingival epithelium, human penis, lacrimal gland, lactiferous duct, lactiferous gland, left lung lobe, maxillary prominence, myocardium of left ventricle, nipple, right lung, right lung lobe, right ventricle, skin of arm, trachea, vestibular membrane of cochlear duct, vulva
RNA expression pattern · 20
IRX3 → abdominal wall, bronchial epithelial cell, calvaria, epithelium of lactiferous gland, gingival epithelium, human penis, lacrimal gland, lactiferous duct, lactiferous gland, left lung lobe, maxillary prominence, myocardium of left ventricle, nipple, right lung, right lung lobe, right ventricle, skin of arm, trachea, vestibular membrane of cochlear duct, vulva
related to Function · 20
IRX3 → Additionally, Brugada, Embryonically, Gja1-encoded Connexin-43, Gja5-encoded Connexin-40, Iroquois, Members, MN, NKX2-2, Nkx6, Purkinje, QRS, Sonic, Specifically, The Irx3, V0, V1, V2, V3, VCS
Gene ontology · 17
IRX3 → axon, cytoplasm, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, energy homeostasis, mesoderm development, metanephros development, multicellular organism development, negative regulation of neuron differentiation, nucleus, positive regulation of neuron differentiation, proximal/distal pattern formation involved in nephron development, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, sequence-specific DNA binding, specification of loop of Henle identity, transcription, DNA-templated
related to Aberrant expression in acute leukaemia · 12
IRX3 → AML, B-ALL, Expression, Focal, FTO, HSPCs, In AML, Recurrent, RNA, T-ALL, Together, Usually
related to Association with obesity · 6
IRX3 → FTO, Genetic, IRX3-deficient, IRX5, Manipulation, Obesity-associated
Band · 2
IRX3 → 16q12.2, 8 C5|8 44.55 cM
Chr. · 2
IRX3 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
IRX3 → 54,286,787 bp, 92,528,695 bp
Aliases · 1
IRX3 → IRX3, IRX-1, IRXB1, iroquois homeobox 3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

expression human fto bp gene iroquois chr band expressed also chromosome 16 location function genes obesity mouse homeobox family protein

IRX3 relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around IRX3. Examples in this analysis include IRX3 → Aliases → IRX3, IRX-1, IRXB1, iroquois homeobox 3 and IRX3 → Band → 16q12.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
IRX3AliasesIRX3, IRX-1, IRXB1, iroquois homeobox 31.00infobox
IRX3Band16q12.21.00infobox
IRX3Band8 C5|8 44.55 cM1.00infobox
IRX3Bgeenipple1.00infobox
IRX3Bgeehuman penis1.00infobox
IRX3Bgeeskin of arm1.00infobox
IRX3Bgeemyocardium of left ventricle1.00infobox
IRX3Bgeebronchial epithelial cell1.00infobox
IRX3Bgeevulva1.00infobox
IRX3Bgeeepithelium of lactiferous gland1.00infobox
IRX3Bgeelactiferous duct1.00infobox
IRX3Bgeetrachea1.00infobox
IRX3Bgeegingival epithelium1.00infobox
IRX3Bgeelacrimal gland1.00infobox
IRX3Bgeeleft lung lobe1.00infobox
IRX3Bgeemaxillary prominence1.00infobox
IRX3Bgeecalvaria1.00infobox
IRX3Bgeeabdominal wall1.00infobox
IRX3Bgeevestibular membrane of cochlear duct1.00infobox
IRX3Bgeelactiferous gland1.00infobox
IRX3Bgeeright lung1.00infobox
IRX3Bgeeright lung lobe1.00infobox
IRX3Bgeeright ventricle1.00infobox
IRX3BioGPSn/a1.00infobox
IRX3Chr.Chromosome 16 (human)1.00infobox
IRX3Chr.Chromosome 8 (mouse)1.00infobox
IRX3DatabasesNCBI: entry; OMA: entry1.00infobox
IRX3End54,286,787 bp1.00infobox
IRX3End92,528,695 bp1.00infobox
IRX3EnsemblENSG000001775081.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around IRX3 bring nearby vocabulary together. In this analysis, examples include Expression, Fto and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • IRX3
    • Expression
    • Fto
    • Human
    • Obesity
    • Expressed
    • Intron
    • Mice
    • Function
    • Location
    • Genes
    • Development
    • Protein
  • irx3
    • Expression
    • Fto
    • Human
    • Obesity
    • Expressed
    • Intron
    • Mice
    • Function
    • Location
    • Genes
    • Development
    • Protein
  • protein
    • Iroquois
    • C5
    • Development
    • End
    • Gene
    • Homeodomain
    • Humans
    • Formation
    • Homeobox
    • Mouse
    • Pattern
    • Band
  • gene
    • Iroquois
    • Homeobox
    • Chromosome
    • Location
    • Bp
    • Chr
    • C5
    • Development
    • End
    • Homeodomain
    • Protein
    • Human
  • iroquois homeobox
    • Iroquois
    • Family
    • Gene
    • Development
    • Protein
    • Chromosome
    • Function
    • Location
    • Bp
    • Chr
    • Genes
    • Homeodomain
  • function
    • Conduction
    • Vcs
    • Chromosome
    • Location
    • Bp
    • Chr
    • Iroquois
    • Expressed
    • Gene
    • Human
    • C5
    • Development
  • iroquois
    • Family
    • Development
    • Protein
    • Chromosome
    • Function
    • Location
    • Bp
    • Chr
    • Genes
    • Expressed
    • Human
    • C5
  • fto
    • Intron
    • Irx3
    • Genes
    • Human
    • Mouse
    • Location
    • Obesity

Connections between topic areas Semantic bridges

For IRX3, one of the stronger structural bridges in this analysis connects IRX3 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IRX3 — Clinical significance · splits 11 ⟂ 9
IRX3 — Function · splits 15 ⟂ 5
IRX3 — Overview · splits 17 ⟂ 3

Map overview Semantic statistics

IRX3

Nodes20
Edges19
Triples115
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around IRX3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Function & Discovery and name, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — IRX3 · EN edition · Analysis: TopicsToTalkAbout

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