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IRX3

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.

Clinical significance, Function & Discovery and name

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Clinical significance

8 related topics

Function

4 related topics

Discovery and name

1 related topics

Overview

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Key facts & relationships

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Aliases
IRX3, IRX-1, IRXB1, iroquois homeobox 3
Band
16q12.2 · 8 C5|8 44.55 cM
Bgee
nipple · human penis · skin of arm · myocardium of left ventricle · bronchial epithelial cell
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

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Overview

Discovery and name

Function

Clinical significance

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Map overview Semantic statistics

IRX3

Nodes20
Edges19
Triples120
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

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IRX3

Top relations

related to Function · 24
IRX3 → Additionally, Brugada, Embryonically, For, Gja1-encoded Connexin-43, Gja5-encoded Connexin-40, In, Iroquois, Its, Members, MN, NKX2-2, Nkx6, Purkinje, QRS, Sonic, Specifically, The, The Irx3, V0
Bgee · 20
IRX3 → abdominal wall, bronchial epithelial cell, calvaria, epithelium of lactiferous gland, gingival epithelium, human penis, lacrimal gland, lactiferous duct, lactiferous gland, left lung lobe, maxillary prominence, myocardium of left ventricle, nipple, right lung, right lung lobe, right ventricle, skin of arm, trachea, vestibular membrane of cochlear duct, vulva
RNA expression pattern · 20
IRX3 → abdominal wall, bronchial epithelial cell, calvaria, epithelium of lactiferous gland, gingival epithelium, human penis, lacrimal gland, lactiferous duct, lactiferous gland, left lung lobe, maxillary prominence, myocardium of left ventricle, nipple, right lung, right lung lobe, right ventricle, skin of arm, trachea, vestibular membrane of cochlear duct, vulva
Gene ontology · 17
IRX3 → axon, cytoplasm, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, energy homeostasis, mesoderm development, metanephros development, multicellular organism development, negative regulation of neuron differentiation, nucleus, positive regulation of neuron differentiation, proximal/distal pattern formation involved in nephron development, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, sequence-specific DNA binding, specification of loop of Henle identity, transcription, DNA-templated
related to Aberrant expression in acute leukaemia · 12
IRX3 → AML, B-ALL, Expression, Focal, FTO, HSPCs, In AML, Recurrent, RNA, T-ALL, Together, Usually
related to Association with obesity · 7
IRX3 → FTO, Genetic, IRX3-deficient, IRX5, Manipulation, Obesity-associated, This
Band · 2
IRX3 → 16q12.2, 8 C5|8 44.55 cM
Chr. · 2
IRX3 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
IRX3 → 54,286,787 bp, 92,528,695 bp
Aliases · 1
IRX3 → IRX3, IRX-1, IRXB1, iroquois homeobox 3

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Important terminology

expression human fto bp gene iroquois chr band expressed also chromosome 16 location function genes obesity mouse homeobox family protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IRX3AliasesIRX3, IRX-1, IRXB1, iroquois homeobox 31.00infobox
IRX3Band16q12.21.00infobox
IRX3Band8 C5|8 44.55 cM1.00infobox
IRX3Bgeenipple1.00infobox
IRX3Bgeehuman penis1.00infobox
IRX3Bgeeskin of arm1.00infobox
IRX3Bgeemyocardium of left ventricle1.00infobox
IRX3Bgeebronchial epithelial cell1.00infobox
IRX3Bgeevulva1.00infobox
IRX3Bgeeepithelium of lactiferous gland1.00infobox
IRX3Bgeelactiferous duct1.00infobox
IRX3Bgeetrachea1.00infobox
IRX3Bgeegingival epithelium1.00infobox
IRX3Bgeelacrimal gland1.00infobox
IRX3Bgeeleft lung lobe1.00infobox
IRX3Bgeemaxillary prominence1.00infobox
IRX3Bgeecalvaria1.00infobox
IRX3Bgeeabdominal wall1.00infobox
IRX3Bgeevestibular membrane of cochlear duct1.00infobox
IRX3Bgeelactiferous gland1.00infobox
IRX3Bgeeright lung1.00infobox
IRX3Bgeeright lung lobe1.00infobox
IRX3Bgeeright ventricle1.00infobox
IRX3BioGPSn/a1.00infobox
IRX3Chr.Chromosome 16 (human)1.00infobox
IRX3Chr.Chromosome 8 (mouse)1.00infobox
IRX3DatabasesNCBI: entry; OMA: entry1.00infobox
IRX3End54,286,787 bp1.00infobox
IRX3End92,528,695 bp1.00infobox
IRX3EnsemblENSG000001775081.00infobox

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