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Ibutilide: Pharmacokinetics, Adverse effects and contraindications & Mechanism of action

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Because of its Class III…

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Ibutilide topic overview

The analysis highlights Pharmacokinetics, Adverse effects and contraindications and Mechanism of action as prominent areas in the source structure around Ibutilide.

Related topics
15
Source areas
4
Connected nodes
19
Extracted relationships
44
Concept neighborhoods
12
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics
Pharmacokinetics · 4 topics
Adverse effects and contraindications · 3 topics
Mechanism of action · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01BD05 (WHO)
Bioavailability
N/A
CAS Number
122647-31-8 Y
ChEMBL
ChEMBL533 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Mechanism of action

Pharmacokinetics

Adverse effects and contraindications

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Ibutilide connects Entity context

The extracted context around Ibutilide shows recurring relationship patterns in the source. For example, Ibutilide → Class III, CYP2D6, CYP3A4, Its, P450, The, With Another extracted example is Ibutilide → After, Among, Approximately, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Ibutilide

Top relations

related to Metabolism · 7
Ibutilide → Class III, CYP2D6, CYP3A4, Its, P450, The, With
related to Excretion · 4
Ibutilide → After, Among, Approximately, The
has effect · 3
Ibutilide → Consequently, Like, QT
related to Absorption · 2
Ibutilide → Individual, It
related to Distribution · 2
Ibutilide → Approximately, This
related to Mechanism of action · 2
Ibutilide → III, It
3D model (JSmol) · 1
Ibutilide → Interactive image
AHFS/Drugs.com · 1
Ibutilide → Monograph
ATC code · 1
Ibutilide → C01BD05 (WHO)
Bioavailability · 1
Ibutilide → N/A

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

antiarrhythmic administration class iii atrial fibrillation flutter action current heart rhythm metabolism approximately drug excreted sodium patients hours corvert excretion

Ibutilide relationships Subject–Predicate–Object triples

TTTA extracted 44 structured relationships around Ibutilide. Examples in this analysis include Ibutilide → 3D model (JSmol) → Interactive image and Ibutilide → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Ibutilide3D model (JSmol)Interactive image1.00infobox
IbutilideAHFS/Drugs.comMonograph1.00infobox
IbutilideATC codeC01BD05 (WHO)1.00infobox
IbutilideBioavailabilityN/A1.00infobox
IbutilideCAS Number122647-31-8 Y1.00infobox
IbutilideChEMBLChEMBL533 Y1.00infobox
IbutilideChemSpider54755 Y1.00infobox
IbutilideCompTox Dashboard (EPA)DTXSID208612711.00infobox
IbutilideDrugBankDB00308 Y1.00infobox
IbutilideElimination half-life6 hours (2-12 hours)1.00infobox
IbutilideExcretionRenal (82%), fecal1.00infobox
IbutilideFormulaC20H36N2O3S1.00infobox
IbutilideIUPHAR/BPS72001.00infobox
IbutilideKEGGD08060 Y1.00infobox
IbutilideMedlinePlusa6012481.00infobox
IbutilideMetabolismHepatic oxidation1.00infobox
IbutilideMolar mass384.58 g·mol−11.00infobox
IbutilidePregnancy categoryC1.00infobox
IbutilideProtein binding40%1.00infobox
IbutilidePubChem CID607531.00infobox
IbutilideRoutes of administrationIntravenous1.00infobox
IbutilideTrade namesCorvert1.00infobox
IbutilideUNII2436VX1U9B1.00infobox
Ibutilideis aClass III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Ibutilide bring nearby vocabulary together. In this analysis, examples include Corvert, Distribution and Renal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Ibutilide
    • Corvert
    • Distribution
    • Renal
    • Hours
    • Kg
    • Plasma
    • Rhythm
    • Administration
    • Iii
    • Antiarrhythmic
    • Excretion
    • Bioavailability
  • ibutilide
    • Corvert
    • Distribution
    • Renal
    • Hours
    • Kg
    • Plasma
    • Rhythm
    • Administration
    • Iii
    • Antiarrhythmic
    • Excretion
    • Bioavailability
  • antiarrhythmic
    • Class
    • Iii
    • Agents
    • Action
    • Administration
    • Current
    • Excretion
    • Bioavailability
    • Corvert
    • Distribution
    • Effects
    • Inward
  • action potential
    • Sodium
    • Current
    • Inward
    • Mechanism
    • Potential
    • Slow
    • Myocardial
    • Antiarrhythmic
    • Excretion
    • Bioavailability
    • Corvert
    • Distribution
  • mechanism of action
    • Sodium
    • Current
    • Excretion
    • Inward
    • Mechanism
    • Potential
    • Slow
    • Bioavailability
    • Effects
    • Metabolism
    • Renal
    • Antiarrhythmic
  • potassium current
    • Inward
    • Mechanism
    • Potential
    • Sodium
    • Excretion
    • Bioavailability
    • Corvert
    • Distribution
    • Effects
    • Metabolism
    • Myocardial
    • Renal
  • atrial fibrillation
    • Fibrillation
    • Flutter
    • Inward
    • Mechanism
    • Potential
    • Results
    • Sinus
    • Patients
    • Rhythm
    • Sodium
    • Action
    • Approximately
  • atrial flutter
    • Fibrillation
    • Flutter
    • Inward
    • Mechanism
    • Potential
    • Results
    • Sinus
    • Patients
    • Rhythm
    • Sodium
    • Action
    • Approximately

Connections between topic areas Semantic bridges

For Ibutilide, one of the stronger structural bridges in this analysis connects Ibutilide with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
IbutilideOverview · splits 13 ⟂ 7
IbutilidePharmacokinetics · splits 15 ⟂ 5
IbutilideAdverse effects and contraindications · splits 16 ⟂ 4
IbutilideMechanism of action · splits 17 ⟂ 3

Map overview Semantic statistics

Ibutilide

Nodes20
Edges19
Triples44
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around Ibutilide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Pharmacokinetics, Adverse effects and contraindications & Mechanism of action, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Ibutilide · EN edition · Analysis: TopicsToTalkAbout

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