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Ibutilide

Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells. Because of its Class III…

Pharmacokinetics, Adverse effects and contraindications & Mechanism of action

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Pharmacokinetics

BioavailabilityClearanceCYP3A4CYP2D6
4 related topics

Adverse effects and contraindications

Abnormal heart rhythmsQT intervalTorsades de pointes
3 related topics

Mechanism of action

Potassium currentAction potential
2 related topics

Overview

AntiarrhythmicAtrial fibrillationAtrial flutterRefractory periodPfizer
6 related topics

Key facts & relationships

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01BD05 (WHO)
Bioavailability
N/A
CAS Number
122647-31-8 Y
ChEMBL
ChEMBL533 Y

Topics to explore

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Overview

Mechanism of action

Pharmacokinetics

Adverse effects and contraindications

Advanced semantic analysis

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Map overview Semantic statistics

Ibutilide

Nodes20
Edges19
Triples44
Avg. degree1.9
Density0.1
Components1

How this topic connects Entity context

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Ibutilide

Top relations

related to Metabolism · 7
Ibutilide → Class III, CYP2D6, CYP3A4, Its, P450, The, With
related to Excretion · 4
Ibutilide → After, Among, Approximately, The
has effect · 3
Ibutilide → Consequently, Like, QT
related to Absorption · 2
Ibutilide → Individual, It
related to Distribution · 2
Ibutilide → Approximately, This
related to Mechanism of action · 2
Ibutilide → III, It
3D model (JSmol) · 1
Ibutilide → Interactive image
AHFS/Drugs.com · 1
Ibutilide → Monograph
ATC code · 1
Ibutilide → C01BD05 (WHO)
Bioavailability · 1
Ibutilide → N/A

Important terminology Word statistics

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Important terminology

antiarrhythmic administration class iii atrial fibrillation flutter action current heart rhythm metabolism approximately drug excreted sodium patients hours corvert excretion

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ibutilide3D model (JSmol)Interactive image1.00infobox
IbutilideAHFS/Drugs.comMonograph1.00infobox
IbutilideATC codeC01BD05 (WHO)1.00infobox
IbutilideBioavailabilityN/A1.00infobox
IbutilideCAS Number122647-31-8 Y1.00infobox
IbutilideChEMBLChEMBL533 Y1.00infobox
IbutilideChemSpider54755 Y1.00infobox
IbutilideCompTox Dashboard (EPA)DTXSID208612711.00infobox
IbutilideDrugBankDB00308 Y1.00infobox
IbutilideElimination half-life6 hours (2-12 hours)1.00infobox
IbutilideExcretionRenal (82%), fecal1.00infobox
IbutilideFormulaC20H36N2O3S1.00infobox
IbutilideIUPHAR/BPS72001.00infobox
IbutilideKEGGD08060 Y1.00infobox
IbutilideMedlinePlusa6012481.00infobox
IbutilideMetabolismHepatic oxidation1.00infobox
IbutilideMolar mass384.58 g·mol−11.00infobox
IbutilidePregnancy categoryC1.00infobox
IbutilideProtein binding40%1.00infobox
IbutilidePubChem CID607531.00infobox
IbutilideRoutes of administrationIntravenous1.00infobox
IbutilideTrade namesCorvert1.00infobox
IbutilideUNII2436VX1U9B1.00infobox
Ibutilideis aClass III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm0.90text

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    Min side: 3
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