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Hydroxyflutamide: Overview, Related Topics & Entities

Hydroxyflutamide (developmental code SCH-16423; also known as 2-hydroxyflutamide, HF, and OHF) is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of flutamide, which is considered to be a prodrug of hydroxyflutamide as the active form. It has been reported to possess an IC50 of 700 nM for the androgen receptor (AR), which is about…

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Hydroxyflutamide topic overview

The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around Hydroxyflutamide.

Related topics
7
Source areas
1
Connected nodes
8
Extracted relationships
15
Concept neighborhoods
9
Bridge connections
8

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
CAS Number
52806-53-8
ChEBI
CHEBI:43064
ChEMBL
ChEMBL491
ChemSpider
82752
CompTox Dashboard (EPA)
DTXSID8033562

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Hydroxyflutamide connects Entity context

The extracted context around Hydroxyflutamide shows recurring relationship patterns in the source. For example, Hydroxyflutamide → Interactive image Another extracted example is Hydroxyflutamide → 52806-53-8. Use these groups to spot repeated connection types before inspecting the individual relationships.

Hydroxyflutamide

Top relations

3D model (JSmol) · 1
Hydroxyflutamide → Interactive image
CAS Number · 1
Hydroxyflutamide → 52806-53-8
ChEBI · 1
Hydroxyflutamide → CHEBI:43064
ChEMBL · 1
Hydroxyflutamide → ChEMBL491
ChemSpider · 1
Hydroxyflutamide → 82752
CompTox Dashboard (EPA) · 1
Hydroxyflutamide → DTXSID8033562
Drug class · 1
Hydroxyflutamide → Nonsteroidal antiandrogen
ECHA InfoCard · 1
Hydroxyflutamide → 100.169.708
Formula · 1
Hydroxyflutamide → C11H11F3N2O4
IUPHAR/BPS · 1
Hydroxyflutamide → 2862

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

sch-16423 2-hydroxyflutamide hf ohf nonsteroidal antiandrogen flutamide prodrug ic50 bicalutamide developmental code also known nsaa major active metabolite considered form

Hydroxyflutamide relationships Subject–Predicate–Object triples

TTTA extracted 15 structured relationships around Hydroxyflutamide. Examples in this analysis include Hydroxyflutamide → 3D model (JSmol) → Interactive image and Hydroxyflutamide → CAS Number → 52806-53-8. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Hydroxyflutamide3D model (JSmol)Interactive image1.00infobox
HydroxyflutamideCAS Number52806-53-81.00infobox
HydroxyflutamideChEBICHEBI:430641.00infobox
HydroxyflutamideChEMBLChEMBL4911.00infobox
HydroxyflutamideChemSpider827521.00infobox
HydroxyflutamideCompTox Dashboard (EPA)DTXSID80335621.00infobox
HydroxyflutamideDrug classNonsteroidal antiandrogen1.00infobox
HydroxyflutamideECHA InfoCard100.169.7081.00infobox
HydroxyflutamideFormulaC11H11F3N2O41.00infobox
HydroxyflutamideIUPHAR/BPS28621.00infobox
HydroxyflutamideKEGGC142041.00infobox
HydroxyflutamideMolar mass292.214 g·mol−11.00infobox
HydroxyflutamideOther names2-Hydroxyflutamide; HF; OHF; Flutamide-hydroxide; SCH-16423; Hydroxyniphtholide; Hydroxyniftolide; α,α,α-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide1.00infobox
HydroxyflutamidePubChem CID916491.00infobox
HydroxyflutamideUNII31D90UKP5Y1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Hydroxyflutamide bring nearby vocabulary together. In this analysis, examples include 2-hydroxyflutamide, Antiandrogen and Hf. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Hydroxyflutamide
    • 2-hydroxyflutamide
    • Antiandrogen
    • Hf
    • Nonsteroidal
    • Ohf
    • Sch-16423
    • Active
    • Also
    • Considered
    • Flutamide
    • Form
    • Known
  • hydroxyflutamide
    • 2-hydroxyflutamide
    • Antiandrogen
    • Hf
    • Nonsteroidal
    • Ohf
    • Sch-16423
    • Active
    • Also
    • Considered
    • Flutamide
    • Form
    • Known
  • nonsteroidal antiandrogen
    • Hf
    • Hydroxyflutamide
    • Nonsteroidal
    • Ohf
    • Sch-16423
    • Active
    • Code
    • Considered
    • Developmental
    • Flutamide
    • Form
    • Known
  • active metabolite
    • Also
    • Code
    • Considered
    • Developmental
    • Flutamide
    • Form
    • Known
    • Major
    • Metabolite
    • Nsaa
    • Prodrug
    • Antiandrogen
  • flutamide
    • Considered
    • Form
    • Known
    • Major
    • Metabolite
    • Nsaa
    • Prodrug
    • Hf
    • Hydroxyflutamide
    • Nonsteroidal
    • Ohf
    • Sch-16423
  • ic50
    • 4-fold
    • Androgen
    • Ar
    • Bicalutamide
    • Less
    • Nm
    • Possess
    • Receptor
    • Reported
  • androgen receptor
    • 4-fold
    • Ar
    • Bicalutamide
    • Ic50
    • Less
    • Nm
    • Possess
    • Receptor
    • Reported
  • bicalutamide
    • Ic50
    • Less
    • Nm
    • Possess
    • Receptor
    • Reported

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the Hydroxyflutamide map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

Hydroxyflutamide

Nodes9
Edges8
Triples15
Avg. degree1.78
Density0.222222
Components1

Source & methodology

TTTA analyzes the structure around Hydroxyflutamide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Hydroxyflutamide · EN edition · Analysis: TopicsToTalkAbout

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