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Hydroxyflutamide (developmental code SCH-16423; also known as 2-hydroxyflutamide, HF, and OHF) is a nonsteroidal antiandrogen (NSAA) and the major active metabolite of flutamide, which is considered to be a prodrug of hydroxyflutamide as the active form. It has been reported to possess an IC50 of 700 nM for the androgen receptor (AR), which is about…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around Hydroxyflutamide.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around Hydroxyflutamide shows recurring relationship patterns in the source. For example, Hydroxyflutamide → Interactive image Another extracted example is Hydroxyflutamide → 52806-53-8. Use these groups to spot repeated connection types before inspecting the individual relationships.
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sch-16423 2-hydroxyflutamide hf ohf nonsteroidal antiandrogen flutamide prodrug ic50 bicalutamide developmental code also known nsaa major active metabolite considered form
TTTA extracted 15 structured relationships around Hydroxyflutamide. Examples in this analysis include Hydroxyflutamide → 3D model (JSmol) → Interactive image and Hydroxyflutamide → CAS Number → 52806-53-8. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Hydroxyflutamide | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Hydroxyflutamide | CAS Number | 52806-53-8 | 1.00 | infobox |
| Hydroxyflutamide | ChEBI | CHEBI:43064 | 1.00 | infobox |
| Hydroxyflutamide | ChEMBL | ChEMBL491 | 1.00 | infobox |
| Hydroxyflutamide | ChemSpider | 82752 | 1.00 | infobox |
| Hydroxyflutamide | CompTox Dashboard (EPA) | DTXSID8033562 | 1.00 | infobox |
| Hydroxyflutamide | Drug class | Nonsteroidal antiandrogen | 1.00 | infobox |
| Hydroxyflutamide | ECHA InfoCard | 100.169.708 | 1.00 | infobox |
| Hydroxyflutamide | Formula | C11H11F3N2O4 | 1.00 | infobox |
| Hydroxyflutamide | IUPHAR/BPS | 2862 | 1.00 | infobox |
| Hydroxyflutamide | KEGG | C14204 | 1.00 | infobox |
| Hydroxyflutamide | Molar mass | 292.214 g·mol−1 | 1.00 | infobox |
| Hydroxyflutamide | Other names | 2-Hydroxyflutamide; HF; OHF; Flutamide-hydroxide; SCH-16423; Hydroxyniphtholide; Hydroxyniftolide; α,α,α-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide | 1.00 | infobox |
| Hydroxyflutamide | PubChem CID | 91649 | 1.00 | infobox |
| Hydroxyflutamide | UNII | 31D90UKP5Y | 1.00 | infobox |
The concept neighborhoods around Hydroxyflutamide bring nearby vocabulary together. In this analysis, examples include 2-hydroxyflutamide, Antiandrogen and Hf. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the Hydroxyflutamide map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Hydroxyflutamide to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Hydroxyflutamide · EN edition · Analysis: TopicsToTalkAbout