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HSD17B2: Function, Expression & Clinical significance

17β-Hydroxysteroid dehydrogenase 2 (17β-HSD2) is an enzyme of the 17β-hydroxysteroid dehydrogenase (17β-HSD) family that in humans is encoded by the HSD17B2 gene.

Language: English [EN]
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HSD17B2 topic overview

The analysis highlights Function, Expression and Clinical significance as prominent areas in the source structure around HSD17B2.

Related topics
36
Source areas
4
Connected nodes
40
Extracted relationships
79
Concept neighborhoods
17
Bridge connections
40

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 14 topics
Expression · 10 topics
Clinical significance · 9 topics
Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.1.1.239
1.1.1.62
Aliases
HSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2
Band
16q23.3 · 8|8 E1
Bgee
jejunal mucosa · duodenum · mucosa of transverse colon · mucosa of ileum · right lobe of liver
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Expression

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HSD17B2 connects Entity context

The extracted context around HSD17B2 shows recurring relationship patterns in the source. For example, HSD17B2 → corneal stroma, duodenum, epithelium of stomach, esophagus, ileum, jejunal mucosa, jejunum, left colon, left lobe of liver, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucosa of urinary bladder, olfactory zone of nasal mucosa, placenta, pyloric antrum, rectum, right lobe of liver, transitional epithelium of urinary bladder, yolk sac Another extracted example is HSD17B2 → 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, endoplasmic reticulum membrane, estradiol 17-beta-dehydrogenase activity, estrogen biosynthetic process, in utero embryonic development, integral component of membrane, lipid metabolism, membrane, oxidoreductase activity, placenta development, response to retinoic acid, steroid biosynthetic process, testosterone dehydrogenase (NAD+) activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

HSD17B2

Top relations

Bgee · 20
HSD17B2 → corneal stroma, duodenum, epithelium of stomach, esophagus, ileum, jejunal mucosa, jejunum, left colon, left lobe of liver, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucosa of urinary bladder, olfactory zone of nasal mucosa, placenta, pyloric antrum, rectum, right lobe of liver, transitional epithelium of urinary bladder, yolk sac
RNA expression pattern · 20
HSD17B2 → corneal stroma, duodenum, epithelium of stomach, esophagus, ileum, jejunal mucosa, jejunum, left colon, left lobe of liver, mucosa of ileum, mucosa of sigmoid colon, mucosa of transverse colon, mucosa of urinary bladder, olfactory zone of nasal mucosa, placenta, pyloric antrum, rectum, right lobe of liver, transitional epithelium of urinary bladder, yolk sac
Gene ontology · 13
HSD17B2 → 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, endoplasmic reticulum membrane, estradiol 17-beta-dehydrogenase activity, estrogen biosynthetic process, in utero embryonic development, integral component of membrane, lipid metabolism, membrane, oxidoreductase activity, placenta development, response to retinoic acid, steroid biosynthetic process, testosterone dehydrogenase (NAD+) activity
related to Clinical significance · 3
HSD17B2 → HSD2, Inactivating, Polymorphisms
Band · 2
HSD17B2 → 16q23.3, 8|8 E1
Chr. · 2
HSD17B2 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
HSD17B2 → 118,485,766 bp, 82,098,534 bp
1.1.1.239 · 1
HSD17B2 → ↗
1.1.1.62 · 1
HSD17B2 → ↗
Aliases · 1
HSD17B2 → HSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human band gene 17β-hsd2 dehydrogenase chromosome 16 enzyme activity location 17β-hsd mouse function expression 098 534 end 82

HSD17B2 relationships Subject–Predicate–Object triples

TTTA extracted 79 structured relationships around HSD17B2. Examples in this analysis include HSD17B2 → 1.1.1.239 → ↗ and HSD17B2 → Aliases → HSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HSD17B21.1.1.2391.00infobox
HSD17B21.1.1.621.00infobox
HSD17B2AliasesHSD17B2, EDH17B2, HSD17, SDR9C2, hydroxysteroid (17-beta) dehydrogenase 2, hydroxysteroid 17-beta dehydrogenase 21.00infobox
HSD17B2Band16q23.31.00infobox
HSD17B2Band8|8 E11.00infobox
HSD17B2Bgeejejunal mucosa1.00infobox
HSD17B2Bgeeduodenum1.00infobox
HSD17B2Bgeemucosa of transverse colon1.00infobox
HSD17B2Bgeemucosa of ileum1.00infobox
HSD17B2Bgeeright lobe of liver1.00infobox
HSD17B2Bgeerectum1.00infobox
HSD17B2Bgeeplacenta1.00infobox
HSD17B2Bgeemucosa of urinary bladder1.00infobox
HSD17B2Bgeemucosa of sigmoid colon1.00infobox
HSD17B2Bgeeolfactory zone of nasal mucosa1.00infobox
HSD17B2Bgeeleft lobe of liver1.00infobox
HSD17B2Bgeetransitional epithelium of urinary bladder1.00infobox
HSD17B2Bgeeleft colon1.00infobox
HSD17B2Bgeeesophagus1.00infobox
HSD17B2Bgeepyloric antrum1.00infobox
HSD17B2Bgeeyolk sac1.00infobox
HSD17B2Bgeeileum1.00infobox
HSD17B2Bgeeepithelium of stomach1.00infobox
HSD17B2Bgeejejunum1.00infobox
HSD17B2Bgeecorneal stroma1.00infobox
HSD17B2BioGPSMore reference expression data1.00infobox
HSD17B2Chr.Chromosome 16 (human)1.00infobox
HSD17B2Chr.Chromosome 8 (mouse)1.00infobox
HSD17B2DatabasesNCBI: entry; OMA: entry1.00infobox
HSD17B2End82,098,534 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HSD17B2 bring nearby vocabulary together. In this analysis, examples include Gene, Expression and Function. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HSD17B2
    • Gene
    • Expression
    • Function
    • Location
    • Activity
    • Chromosome
    • Human
    • Bp
    • Chr
    • Clinical
    • Estradiol
    • Estrogen
  • hsd17b2
    • Gene
    • Expression
    • Function
    • Location
    • Activity
    • Chromosome
    • Human
    • Bp
    • Chr
    • Clinical
    • Estradiol
    • Estrogen
  • 17β-hydroxysteroid dehydrogenase
    • Encoded
    • Family
    • Humans
    • Activity
    • Enzyme
    • Gene
    • Hsd17b2
    • Expression
    • Function
    • Location
    • 17β-hsd
    • Chromosome
  • 20α-hydroxysteroid dehydrogenase
    • Activity
    • Enzyme
    • Gene
    • Hsd17b2
    • Expression
    • Function
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • Clinical
  • gene
    • Location
    • Chromosome
    • Hsd17b2
    • Human
    • Bp
    • Chr
    • End
    • Expression
    • Function
    • Mouse
    • Activity
    • Band
  • testosterone
    • Estradiol
    • Estrogen
    • End
    • Expressed
    • Expression
    • Function
    • Liver
    • Mouse
    • Placenta
    • 17β-hsd
    • Location
    • Activity
  • expression
    • Function
    • Location
    • Activity
    • Chromosome
    • Clinical
    • Estradiol
    • Estrogen
    • Gene
    • Hsd17b2
    • Human
    • References
    • Significance
  • function
    • Location
    • Activity
    • Chromosome
    • Estradiol
    • Estrogen
    • Gene
    • Hsd17b2
    • Human
    • References
    • Significance
    • Testosterone
    • Bp

Connections between topic areas Semantic bridges

For HSD17B2, one of the stronger structural bridges in this analysis connects HSD17B2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HSD17B2Function · splits 26 ⟂ 15
HSD17B2Expression · splits 30 ⟂ 11
HSD17B2Clinical significance · splits 31 ⟂ 10
HSD17B2Overview · splits 37 ⟂ 4

Map overview Semantic statistics

HSD17B2

Nodes41
Edges40
Triples79
Avg. degree1.95
Density0.04878
Components1

Source & methodology

TTTA analyzes the structure around HSD17B2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Expression & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HSD17B2 · EN edition · Analysis: TopicsToTalkAbout

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