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Holin: Classification & Overview

Holins are a diverse group of small proteins produced by dsDNA bacteriophages in order to trigger and control the degradation of the host's cell wall at the end of the lytic cycle. Holins form pores in the host's cell membrane, allowing lysins to reach and degrade peptidoglycan, a component of bacterial cell walls. Holins have been shown to regulate the…

Language: English [EN]
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Holin topic overview

The analysis highlights Classification and Overview as prominent areas in the source structure around Holin.

Related topics
61
Source areas
2
Connected nodes
63
Extracted relationships
54
Concept neighborhoods
53
Bridge connections
63

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Classification · 46 topics
Overview · 15 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Classification

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Holin connects Entity context

The extracted context around Holin shows recurring relationship patterns in the source. For example, Holin → Archaea, Bacteria, Bacteriology, BBA, Bhaskara, Bin, Biochimica, Biomedical Applications, Biomembranes, Biophysica Acta, Bläsi, Characterization, Du, Eukaryotes, FEMS Microbiology Reviews, Hengan, Holins, JB, Ji, Jianhe Another extracted example is Holin → According, IHolin, IIHolin, IIIHolin, IVHolin, Transporter Classification Database, VHolin, VIHolin, VII. Use these groups to spot repeated connection types before inspecting the individual relationships.

Holin

Top relations

related to Further reading · 43
Holin → Archaea, Bacteria, Bacteriology, BBA, Bhaskara, Bin, Biochimica, Biomedical Applications, Biomembranes, Biophysica Acta, Bläsi, Characterization, Du, Eukaryotes, FEMS Microbiology Reviews, Hengan, Holins, JB, Ji, Jianhe
related to Gene families · 9
Holin → According, IHolin, IIHolin, IIIHolin, IVHolin, Transporter Classification Database, VHolin, VIHolin, VII
related to Structure · 1
Holin → According

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

holins class families protein phage bacterial proteins membrane doi pmid bacteriophage ii iii gene lysins include 10 form periplasm diverse

Holin relationships Subject–Predicate–Object triples

TTTA extracted 54 structured relationships around Holin. Examples in this analysis include the S protein of lambdoid phage 21 act by forming heptameric channels that depolarize the bacterial membrane → instance of → pinholins and Holin → related to Further reading → Reddy. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
the S protein of lambdoid phage 21 act by forming heptameric channels that depolarize the bacterial membraneinstance ofpinholins0.80text
Holinrelated to Further readingReddy0.60section
Holinrelated to Further readingBhaskara0.60section
Holinrelated to Further readingSaier Jr0.60section
Holinrelated to Further readingMilton0.60section
Holinrelated to Further readingTopological0.60section
Holinrelated to Further readingBiochimica0.60section
Holinrelated to Further readingBiophysica Acta0.60section
Holinrelated to Further readingBBA0.60section
Holinrelated to Further readingBiomembranes0.60section
Holinrelated to Further readingPMC0.60section
Holinrelated to Further readingPMID0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Holin bring nearby vocabulary together. In this analysis, examples include Superfamilies, Protein and Iii. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • the putative bacterial archaeal holin (bah) family
    • Pores
    • Membrane
    • Superfamilies
    • Protein
    • Phage
    • Cell
    • Cycle
    • Host's
    • Iii
    • Include
    • Lambdoid
    • Lysins
  • gene families
    • Gene
    • Superfamilies
    • Ii
    • Iii
    • Classification
    • Function
    • Group
    • Holin
    • Lytic
    • Proteins
    • Include
    • Phage
  • the gene transfer agent-release holin (gta-hol) family
    • Superfamilies
    • Protein
    • Classification
    • Function
    • Group
    • Iii
    • Include
    • Lytic
    • Phage
    • Proteins
    • Ii
    • Holins
  • lytic cycle
    • Lytic
    • Diverse
    • Group
    • Host's
    • Bacterial
    • Gene
    • Proteins
    • Superfamilies
    • Families
    • Include
    • Phage
    • Holin
  • the firmicute phage φu53 holin (φu53 holin) family
    • Include
    • Examples
    • Superfamilies
    • Protein
    • Bacteriophage
    • Iii
    • Holin
    • Phage
    • Pores
    • Lytic
    • Ii
    • Class
  • the lactococcus lactis phage r1t holin (r1t holin) family
    • Include
    • Examples
    • Superfamilies
    • Protein
    • Bacteriophage
    • Iii
    • Holin
    • Phage
    • Pores
    • Lytic
    • Ii
    • Class
  • the streptomyces aureofaciens phage mu1/6 holin (mu1/6 holin) family
    • Include
    • Examples
    • Superfamilies
    • Protein
    • Bacteriophage
    • Iii
    • Holin
    • Phage
    • Pores
    • Lytic
    • Ii
    • Class
  • the mycobacterial 1 tms phage holin (m1 hol) family
    • Include
    • Examples
    • Superfamilies
    • Protein
    • Bacteriophage
    • Iii
    • Holin
    • Phage
    • Pores
    • Lytic
    • Ii
    • Class

Connections between topic areas Semantic bridges

For Holin, one of the stronger structural bridges in this analysis connects Holin with Classification. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HolinClassification · splits 17 ⟂ 47
HolinOverview · splits 48 ⟂ 16

Map overview Semantic statistics

Holin

Nodes64
Edges63
Triples54
Avg. degree1.97
Density0.03125
Components1

Source & methodology

TTTA analyzes the structure around Holin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Classification & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Holin · EN edition · Analysis: TopicsToTalkAbout

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