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HOGA1

4-Hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) also known as dihydrodipicolinate synthase-like (DHDPSL) is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes (4-hydroxy-2-oxoglutarate aldolase) involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from…

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4.1.3.16
↗
Aliases
HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O
Band
10q24.2 · 19|19 C3
Bgee
right lobe of liver · renal medulla · human kidney · apex of heart · left ventricle
BioGPS
n/a

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HOGA1

Nodes8
Edges7
Triples76
Avg. degree1.75
Density0.25
Components1

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HOGA1

Top relations

Bgee · 19
HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac
RNA expression pattern · 19
HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac
Gene ontology · 13
HOGA1 → 4-hydroxy-2-oxoglutarate aldolase activity, 4-hydroxyproline catabolic process, catalytic activity, glyoxylate catabolic process, glyoxylate metabolic process, lyase activity, metabolism, mitochondrial matrix, mitochondrion, oxalate metabolic process, protein binding, protein homodimerization activity, pyruvate biosynthetic process
Band · 2
HOGA1 → 10q24.2, 19|19 C3
Chr. · 2
HOGA1 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
HOGA1 → 42,059,392 bp, 97,612,802 bp
4.1.3.16 · 1
HOGA1 → ↗
Aliases · 1
HOGA1 → HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1
Available structures · 1
HOGA1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O
BioGPS · 1
HOGA1 → n/a

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Important terminology

bp glyoxylate chr human band 4-hydroxy-2-oxoglutarate aldolase gene enzyme chromosome 10 hydroxyproline location known metabolism oxalate mouse mitochondrial dhdpsl protein

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
HOGA14.1.3.16↗1.00infobox
HOGA1AliasesHOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 11.00infobox
HOGA1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O1.00infobox
HOGA1Band10q24.21.00infobox
HOGA1Band19|19 C31.00infobox
HOGA1Bgeeright lobe of liver1.00infobox
HOGA1Bgeerenal medulla1.00infobox
HOGA1Bgeehuman kidney1.00infobox
HOGA1Bgeeapex of heart1.00infobox
HOGA1Bgeeleft ventricle1.00infobox
HOGA1Bgeeright adrenal cortex1.00infobox
HOGA1Bgeebody of pancreas1.00infobox
HOGA1Bgeeleft adrenal gland1.00infobox
HOGA1BgeeC1 segment1.00infobox
HOGA1Bgeeright auricle of heart1.00infobox
HOGA1Bgeeright kidney1.00infobox
HOGA1Bgeeproximal tubule1.00infobox
HOGA1Bgeeliver1.00infobox
HOGA1Bgeeleft lobe of liver1.00infobox
HOGA1Bgeeyolk sac1.00infobox
HOGA1Bgeespermatid1.00infobox
HOGA1Bgeemuscle of thigh1.00infobox
HOGA1Bgeerenal corpuscle1.00infobox
HOGA1Bgeefetal liver hematopoietic progenitor cell1.00infobox
HOGA1BioGPSn/a1.00infobox
HOGA1Chr.Chromosome 10 (human)1.00infobox
HOGA1Chr.Chromosome 19 (mouse)1.00infobox
HOGA1DatabasesNCBI: entry; OMA: entry1.00infobox
HOGA1End97,612,802 bp1.00infobox
HOGA1End42,059,392 bp1.00infobox

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