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HOGA1: Overview, Related Topics & Entities

4-Hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) also known as dihydrodipicolinate synthase-like (DHDPSL) is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes (4-hydroxy-2-oxoglutarate aldolase) involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from…

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HOGA1 topic overview

The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around HOGA1.

Related topics
6
Source areas
1
Connected nodes
7
Extracted relationships
76
Related term clusters
7
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 6 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

4.1.3.16
↗
Aliases
HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O
Band
10q24.2 · 19|19 C3
Bgee
right lobe of liver · renal medulla · human kidney · apex of heart · left ventricle
BioGPS
n/a

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Explore all related topics Closing gaps

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Overview

For the semantics nerds

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Advanced semantic analysis

How HOGA1 connects Entity context

The extracted context around HOGA1 shows recurring relationship patterns in the source. For example, HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac Another extracted example is HOGA1 → 4-hydroxy-2-oxoglutarate aldolase activity, 4-hydroxyproline catabolic process, catalytic activity, glyoxylate catabolic process, glyoxylate metabolic process, lyase activity, metabolism, mitochondrial matrix, mitochondrion, oxalate metabolic process, protein binding, protein homodimerization activity, pyruvate biosynthetic process. Use these groups to spot repeated connection types before inspecting the individual relationships.

HOGA1

Top relations

Bgee · 19
HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac
RNA expression pattern · 19
HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac
Gene ontology · 13
HOGA1 → 4-hydroxy-2-oxoglutarate aldolase activity, 4-hydroxyproline catabolic process, catalytic activity, glyoxylate catabolic process, glyoxylate metabolic process, lyase activity, metabolism, mitochondrial matrix, mitochondrion, oxalate metabolic process, protein binding, protein homodimerization activity, pyruvate biosynthetic process
Band · 2
HOGA1 → 10q24.2, 19|19 C3
Chr. · 2
HOGA1 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
HOGA1 → 42,059,392 bp, 97,612,802 bp
4.1.3.16 · 1
HOGA1 → ↗
Aliases · 1
HOGA1 → HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1
Available structures · 1
HOGA1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O
BioGPS · 1
HOGA1 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp glyoxylate chr human band 4-hydroxy-2-oxoglutarate aldolase gene enzyme chromosome 10 hydroxyproline location known metabolism oxalate mouse mitochondrial dhdpsl protein

HOGA1 relationships Subject–Predicate–Object triples

TTTA extracted 76 structured relationships around HOGA1. Examples in this analysis include HOGA1 → 4.1.3.16 → ↗ and HOGA1 → Aliases → HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HOGA14.1.3.16↗1.00infobox
HOGA1AliasesHOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 11.00infobox
HOGA1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O1.00infobox
HOGA1Band10q24.21.00infobox
HOGA1Band19|19 C31.00infobox
HOGA1Bgeeright lobe of liver1.00infobox
HOGA1Bgeerenal medulla1.00infobox
HOGA1Bgeehuman kidney1.00infobox
HOGA1Bgeeapex of heart1.00infobox
HOGA1Bgeeleft ventricle1.00infobox
HOGA1Bgeeright adrenal cortex1.00infobox
HOGA1Bgeebody of pancreas1.00infobox
HOGA1Bgeeleft adrenal gland1.00infobox
HOGA1BgeeC1 segment1.00infobox
HOGA1Bgeeright auricle of heart1.00infobox
HOGA1Bgeeright kidney1.00infobox
HOGA1Bgeeproximal tubule1.00infobox
HOGA1Bgeeliver1.00infobox
HOGA1Bgeeleft lobe of liver1.00infobox
HOGA1Bgeeyolk sac1.00infobox
HOGA1Bgeespermatid1.00infobox
HOGA1Bgeemuscle of thigh1.00infobox
HOGA1Bgeerenal corpuscle1.00infobox
HOGA1Bgeefetal liver hematopoietic progenitor cell1.00infobox
HOGA1BioGPSn/a1.00infobox
HOGA1Chr.Chromosome 10 (human)1.00infobox
HOGA1Chr.Chromosome 19 (mouse)1.00infobox
HOGA1DatabasesNCBI: entry; OMA: entry1.00infobox
HOGA1End97,612,802 bp1.00infobox
HOGA1End42,059,392 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around HOGA1 bring nearby vocabulary together. In this analysis, examples include Gene, Activity and Dhdpsl. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HOGA1
    • Gene
    • Activity
    • Dhdpsl
    • Mitochondrial
    • Search
    • Enzyme
    • Location
    • Chromosome
    • Human
    • Also
    • Bp
    • Chr
  • hoga1
    • Gene
    • Activity
    • Dhdpsl
    • Mitochondrial
    • Search
    • Enzyme
    • Location
    • Chromosome
    • Human
    • Also
    • Bp
    • Chr
  • glyoxylate
    • Hydroxyproline
    • Metabolism
    • Oxalate
    • Protein
    • Form
    • Involved
    • One
    • Overactivity
    • Activity
    • End
    • Known
    • Mitochondrial
  • gene
    • Hoga1
    • Location
    • Chromosome
    • Human
    • Activity
    • Bp
    • Chr
    • End
    • Mitochondrial
    • Mouse
    • Search
    • Band
  • enzyme
    • Hoga1
    • Gene
    • Encoded
    • Form
    • Humans
    • Overactivity
    • Synthase-like
    • Activity
    • Hydroxyproline
    • Known
    • Mitochondrial
    • Search
  • hydroxyproline
    • Form
    • Glyoxylate
    • Involved
    • One
    • Overactivity
    • Metabolism
    • Protein
  • oxalate
    • Protein
    • Search

Connections between topic areas Semantic bridges

Bridges highlight paths between different parts of the HOGA1 map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Map overview Semantic statistics

HOGA1

Nodes8
Edges7
Triples76
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around HOGA1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HOGA1 · EN edition · Analysis: TopicsToTalkAbout

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