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4-Hydroxy-2-oxoglutarate aldolase, mitochondrial (HOGA1) also known as dihydrodipicolinate synthase-like (DHDPSL) is an enzyme that in humans is encoded by the HOGA1 gene. The protein is one of the enzymes (4-hydroxy-2-oxoglutarate aldolase) involved in metabolism of hydroxyproline to glyoxylate. The enzyme overactivity can form excessive glyoxylate from…
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around HOGA1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around HOGA1 shows recurring relationship patterns in the source. For example, HOGA1 → apex of heart, body of pancreas, C1 segment, fetal liver hematopoietic progenitor cell, human kidney, left adrenal gland, left lobe of liver, left ventricle, liver, muscle of thigh, proximal tubule, renal corpuscle, renal medulla, right adrenal cortex, right auricle of heart, right kidney, right lobe of liver, spermatid, yolk sac Another extracted example is HOGA1 → 4-hydroxy-2-oxoglutarate aldolase activity, 4-hydroxyproline catabolic process, catalytic activity, glyoxylate catabolic process, glyoxylate metabolic process, lyase activity, metabolism, mitochondrial matrix, mitochondrion, oxalate metabolic process, protein binding, protein homodimerization activity, pyruvate biosynthetic process. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp glyoxylate chr human band 4-hydroxy-2-oxoglutarate aldolase gene enzyme chromosome 10 hydroxyproline location known metabolism oxalate mouse mitochondrial dhdpsl protein
TTTA extracted 76 structured relationships around HOGA1. Examples in this analysis include HOGA1 → 4.1.3.16 → ↗ and HOGA1 → Aliases → HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| HOGA1 | 4.1.3.16 | ↗ | 1.00 | infobox |
| HOGA1 | Aliases | HOGA1, C10orf65, DHDPS2, DHDPSL, HP3, NPL2, 4-hydroxy-2-oxoglutarate aldolase 1 | 1.00 | infobox |
| HOGA1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3S5N, 3S5O | 1.00 | infobox |
| HOGA1 | Band | 10q24.2 | 1.00 | infobox |
| HOGA1 | Band | 19|19 C3 | 1.00 | infobox |
| HOGA1 | Bgee | right lobe of liver | 1.00 | infobox |
| HOGA1 | Bgee | renal medulla | 1.00 | infobox |
| HOGA1 | Bgee | human kidney | 1.00 | infobox |
| HOGA1 | Bgee | apex of heart | 1.00 | infobox |
| HOGA1 | Bgee | left ventricle | 1.00 | infobox |
| HOGA1 | Bgee | right adrenal cortex | 1.00 | infobox |
| HOGA1 | Bgee | body of pancreas | 1.00 | infobox |
| HOGA1 | Bgee | left adrenal gland | 1.00 | infobox |
| HOGA1 | Bgee | C1 segment | 1.00 | infobox |
| HOGA1 | Bgee | right auricle of heart | 1.00 | infobox |
| HOGA1 | Bgee | right kidney | 1.00 | infobox |
| HOGA1 | Bgee | proximal tubule | 1.00 | infobox |
| HOGA1 | Bgee | liver | 1.00 | infobox |
| HOGA1 | Bgee | left lobe of liver | 1.00 | infobox |
| HOGA1 | Bgee | yolk sac | 1.00 | infobox |
| HOGA1 | Bgee | spermatid | 1.00 | infobox |
| HOGA1 | Bgee | muscle of thigh | 1.00 | infobox |
| HOGA1 | Bgee | renal corpuscle | 1.00 | infobox |
| HOGA1 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| HOGA1 | BioGPS | n/a | 1.00 | infobox |
| HOGA1 | Chr. | Chromosome 10 (human) | 1.00 | infobox |
| HOGA1 | Chr. | Chromosome 19 (mouse) | 1.00 | infobox |
| HOGA1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| HOGA1 | End | 97,612,802 bp | 1.00 | infobox |
| HOGA1 | End | 42,059,392 bp | 1.00 | infobox |
The concept neighborhoods around HOGA1 bring nearby vocabulary together. In this analysis, examples include Gene, Activity and Dhdpsl. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the HOGA1 map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around HOGA1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — HOGA1 · EN edition · Analysis: TopicsToTalkAbout