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HHEX: Interactions & Overview

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene and also known as Proline Rich Homeodomain protein PRH.

Language: English [EN]
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HHEX topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around HHEX.

Related topics
7
Source areas
2
Connected nodes
9
Extracted relationships
142
Concept neighborhoods
7
Bridge connections
9

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 5 topics
Interactions · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E1O
Band
10q23.33 · 19 C2|19 32.28 cM
Bgee
secondary oocyte · right lobe of thyroid gland · left lobe of thyroid gland · monocyte · right lobe of liver
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HHEX connects Entity context

The extracted context around HHEX shows recurring relationship patterns in the source. For example, HHEX → animal organ morphogenesis, anterior/posterior pattern specification, B cell differentiation, cell differentiation, cell population proliferation, chromatin binding, common bile duct development, cytoplasm, DNA binding, DNA binding, bending, DNA conformation change, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic heart tube development, embryonic organ development, endoderm development, eukaryotic initiation factor 4E binding, forebrain development, forebrain morphogenesis Another extracted example is HHEX → adrenal gland, blood, body of pancreas, gallbladder, granulocyte, inner renal medulla, left lobe of thyroid gland, liver, monocyte, outer renal medulla, primary oocyte, renal medulla, right lobe of liver, right lobe of thyroid gland, secondary oocyte, spleen, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

HHEX

Top relations

Gene ontology · 70
HHEX → animal organ morphogenesis, anterior/posterior pattern specification, B cell differentiation, cell differentiation, cell population proliferation, chromatin binding, common bile duct development, cytoplasm, DNA binding, DNA binding, bending, DNA conformation change, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, embryonic heart tube development, embryonic organ development, endoderm development, eukaryotic initiation factor 4E binding, forebrain development, forebrain morphogenesis
Bgee · 17
HHEX → adrenal gland, blood, body of pancreas, gallbladder, granulocyte, inner renal medulla, left lobe of thyroid gland, liver, monocyte, outer renal medulla, primary oocyte, renal medulla, right lobe of liver, right lobe of thyroid gland, secondary oocyte, spleen, zygote
RNA expression pattern · 17
HHEX → adrenal gland, blood, body of pancreas, gallbladder, granulocyte, inner renal medulla, left lobe of thyroid gland, liver, monocyte, outer renal medulla, primary oocyte, renal medulla, right lobe of liver, right lobe of thyroid gland, secondary oocyte, spleen, zygote
related to Function · 7
HHEX → Day, It, SCL, The, The HHEX, VEGFA, Without
related to External links · 6
HHEX → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
Band · 2
HHEX → 10q23.33, 19 C2|19 32.28 cM
Chr. · 2
HHEX → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
HHEX → 37,429,179 bp, 92,695,647 bp
Aliases · 1
HHEX → HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox
Available structures · 1
HHEX → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E1O

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein gene bp human chr band transcription homeobox chromosome 10 development factor endothelial expression differentiation location mouse thyroid liver forebrain

HHEX relationships Subject–Predicate–Object triples

TTTA extracted 142 structured relationships around HHEX. Examples in this analysis include HHEX → Aliases → HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox and HHEX → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E1O. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HHEXAliasesHHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox1.00infobox
HHEXAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2E1O1.00infobox
HHEXBand10q23.331.00infobox
HHEXBand19 C2|19 32.28 cM1.00infobox
HHEXBgeesecondary oocyte1.00infobox
HHEXBgeeright lobe of thyroid gland1.00infobox
HHEXBgeeleft lobe of thyroid gland1.00infobox
HHEXBgeemonocyte1.00infobox
HHEXBgeeright lobe of liver1.00infobox
HHEXBgeegranulocyte1.00infobox
HHEXBgeespleen1.00infobox
HHEXBgeebody of pancreas1.00infobox
HHEXBgeegallbladder1.00infobox
HHEXBgeeblood1.00infobox
HHEXBgeerenal medulla1.00infobox
HHEXBgeeprimary oocyte1.00infobox
HHEXBgeeouter renal medulla1.00infobox
HHEXBgeeadrenal gland1.00infobox
HHEXBgeezygote1.00infobox
HHEXBgeeliver1.00infobox
HHEXBgeeinner renal medulla1.00infobox
HHEXBioGPSMore reference expression data1.00infobox
HHEXChr.Chromosome 10 (human)1.00infobox
HHEXChr.Chromosome 19 (mouse)1.00infobox
HHEXDatabasesNCBI: entry; OMA: entry1.00infobox
HHEXEnd92,695,647 bp1.00infobox
HHEXEnd37,429,179 bp1.00infobox
HHEXEnsemblENSG000001528041.00infobox
HHEXEntrez30871.00infobox
HHEXExternal IDsOMIM: 604420; MGI: 96086; GeneCards: HHEX1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HHEX bring nearby vocabulary together. In this analysis, examples include Protein, Development and Cell. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HHEX
    • Protein
    • Development
    • Cell
    • Factor
    • Mice
    • Endothelial
    • Transcription
    • Gene
    • Human
    • Expressed
    • Function
    • Prh
  • hhex
    • Protein
    • Development
    • Cell
    • Factor
    • Mice
    • Endothelial
    • Transcription
    • Gene
    • Human
    • Expressed
    • Function
    • Prh
  • gene
    • Homeobox
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • C2
    • End
    • Expressed
    • Function
    • Mouse
    • Prh
  • transcription factors
    • Factor
    • Cell
    • Differentiation
    • Endothelial
    • Development
    • Gene
    • Hhex
    • C2
    • Developmental
    • End
    • Expressed
    • Function
  • protein
    • Cell
    • Important
    • Endothelial
    • Development
    • Human
    • C2
    • End
    • Expressed
    • Function
    • Mouse
    • Role
    • Search
  • promyelocytic leukemia protein
    • Cell
    • Important
    • Endothelial
    • Development
    • Human
    • C2
    • End
    • Expressed
    • Function
    • Mouse
    • Role
    • Search
  • homeobox
    • Prh
    • Gene
    • External
    • Also
    • Developmental
    • Expressed
    • Function
    • Search
    • Location
    • Chromosome
    • Transcription
    • Hhex

Connections between topic areas Semantic bridges

For HHEX, one of the stronger structural bridges in this analysis connects HHEX with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HHEXOverview · splits 4 ⟂ 6
HHEXInteractions · splits 7 ⟂ 3

Map overview Semantic statistics

HHEX

Nodes10
Edges9
Triples142
Avg. degree1.8
Density0.2
Components1

Source & methodology

TTTA analyzes the structure around HHEX to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HHEX · EN edition · Analysis: TopicsToTalkAbout

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