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Hexobarbital: History, Culture, Applications & Research

Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of…

Language: English [EN]
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Hexobarbital topic overview

The analysis highlights History, Culture, Applications and Research as prominent areas in the source structure around Hexobarbital.

Related topics
47
Source areas
7
Connected nodes
54
Extracted relationships
93
Concept neighborhoods
16
Bridge connections
54

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Toxicity · 19 topics
Synthesis · 8 topics
History · 5 topics
Overview · 5 topics
In popular culture · 4 topics
Reactivity · 4 topics
Application in research · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
N01AF02 (WHO) N05CA16 (WHO)
Boiling point
378.73 °C (713.71 °F)
CAS Number
56-29-1 Y 50-09-9 (sodium salt)
ChEBI
CHEBI:5706 Y
ChEMBL
ChEMBL7728 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Application in research

Synthesis

Reactivity

Toxicity

In popular culture

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Hexobarbital connects Entity context

The extracted context around Hexobarbital shows recurring relationship patterns in the source. For example, Hexobarbital → All, AMPA, And, As, CNS-depressant, GABA, GABA-effect, GABAA, In, It, Moreover, P/Q, The, Therefore, This, When GABA Another extracted example is Hexobarbital → AKR, All, Both, CYP2B1, HB, If, In, NAD, P450, The, These, This, UDP-glucuronosyl, UGTs. Use these groups to spot repeated connection types before inspecting the individual relationships.

Hexobarbital

Top relations

related to Mechanism of actions · 16
Hexobarbital → All, AMPA, And, As, CNS-depressant, GABA, GABA-effect, GABAA, In, It, Moreover, P/Q, The, Therefore, This, When GABA
related to Metabolism · 14
Hexobarbital → AKR, All, Both, CYP2B1, HB, If, In, NAD, P450, The, These, This, UDP-glucuronosyl, UGTs
related to In popular culture · 10
Hexobarbital → Cards, Evipan, Graham Greene's The Heart, Hercule Poirot, In Agatha Christie's, It, Matter, N-methyl-cyclo-hexenyl-methyl-malonyl, Table, Veronal
related to history · 9
Hexobarbital → During World War II, Herta Oberheuser, In Hungary, Nazi, Pregnancy Category, Ravensbrück, Some, The, The FDA
related to Application in research · 6
Hexobarbital → FM, Hexobarbital Sleep Test, HST, PTSD, SM, The
related to Reactivity · 5
Hexobarbital → CYP2B1, CYP3A4, One, P450, Triacetyl
related to Synthesis · 4
Hexobarbital → Another, In, N-methylurea, This
causes · 3
Hexobarbital → an CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect, an CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect.MetabolismThe hepatic metabolism of hexobarbital, the chloride ion channel opening to their longest open state of 9 milli seconds
Legal status · 2
Hexobarbital → CA: Schedule IV, US: Schedule III
has effect · 2
Hexobarbital → Most, The

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects used barbiturates metabolism 3hhb hypnotic sodium cytochrome enantiomer reaction also via 3ohb use man research anesthesia effect chloride p450

Hexobarbital relationships Subject–Predicate–Object triples

TTTA extracted 93 structured relationships around Hexobarbital. Examples in this analysis include Hexobarbital → 3D model (JSmol) → Interactive image and Hexobarbital → ATC code → N01AF02 (WHO) N05CA16 (WHO). The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Hexobarbital3D model (JSmol)Interactive image1.00infobox
HexobarbitalATC codeN01AF02 (WHO) N05CA16 (WHO)1.00infobox
HexobarbitalBoiling point378.73 °C (713.71 °F)1.00infobox
HexobarbitalCAS Number56-29-1 Y 50-09-9 (sodium salt)1.00infobox
HexobarbitalChEBICHEBI:5706 Y1.00infobox
HexobarbitalChEMBLChEMBL7728 Y1.00infobox
HexobarbitalChemSpider3482 Y1.00infobox
HexobarbitalChiralityRacemic mixture1.00infobox
HexobarbitalCompTox Dashboard (EPA)DTXSID90231221.00infobox
HexobarbitalDensity1.1623 g/cm31.00infobox
HexobarbitalDrugBankDB01355 Y1.00infobox
HexobarbitalECHA InfoCard100.000.2411.00infobox
HexobarbitalFormulaC12H16N2O31.00infobox
HexobarbitalKEGGD01071 Y1.00infobox
HexobarbitalLegal statusCA: Schedule IV1.00infobox
HexobarbitalLegal statusUS: Schedule III1.00infobox
HexobarbitalMelting point146.5 °C (295.7 °F)1.00infobox
HexobarbitalMolar mass236.271 g·mol−11.00infobox
HexobarbitalProtein binding25%1.00infobox
HexobarbitalPubChem CID36081.00infobox
HexobarbitalSolubility in water0.435 mg/mL (20 °C)1.00infobox
HexobarbitalTrade namesHexobarbital, Hexobarbitone, Methylhexabital, Methexenyl, Evipal1.00infobox
HexobarbitalUNIIAL8Z8K3P6S1.00infobox
Hexobarbitalcausesthe chloride ion channel opening to their longest open state of 9 milli seconds0.90text
Hexobarbitalcausesan CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect.MetabolismThe hepatic metabolism of hexobarbital0.90text
Hexobarbitalcausesan CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect0.90text
Hexobarbitalis asubstrate0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Hexobarbital bring nearby vocabulary together. In this analysis, examples include Effects, Barbiturates and Sodium. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Hexobarbital
    • Effects
    • Barbiturates
    • Sodium
    • Metabolism
    • Used
    • Receptors
    • Research
    • Cytochrome
    • Effect
    • Gabaa
    • P450
    • Barbiturate
  • hexobarbital
    • Effects
    • Barbiturates
    • Sodium
    • Metabolism
    • Used
    • Receptors
    • Research
    • Cytochrome
    • Effect
    • Gabaa
    • P450
    • Barbiturate
  • barbiturate
    • Hexobarbitone
    • Salt
    • Evipan
    • Gaba
    • Hypnotic
    • Ion
    • Receptor
    • Chloride
    • Gabaa
    • Sodium
    • Effects
    • Hexobarbital
  • sodium methylate
    • Hexobarbitone
    • Salt
    • Barbiturate
    • Effects
    • Acid
    • Evipan
    • Hypnotic
    • Research
    • Hexobarbital
    • Man
    • Barbiturates
    • Metabolism
  • gabaa receptors
    • Gaba
    • Gabaa
    • Ion
    • Receptor
    • Receptors
    • Chloride
    • Barbiturates
    • Inhibitory
    • Effect
    • Enantiomer
    • Open
    • Hexobarbital
  • hydrogen chloride
    • Ion
    • Gaba
    • Open
    • Receptor
    • Gabaa
    • Causes
    • Inhibitory
    • Effect
    • Hexobarbital
  • cytochrome
    • P450
    • Activity
    • Also
    • Reaction
    • Metabolism
    • Form
    • Hexobarbital
  • enantiomer
    • Receptors
    • Form
    • Gabaa
    • Hb
    • 3ohb
    • Reaction
    • Hexobarbital

Connections between topic areas Semantic bridges

For Hexobarbital, one of the stronger structural bridges in this analysis connects Hexobarbital with Toxicity. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Hexobarbital — Toxicity · splits 35 ⟂ 20
Hexobarbital — Synthesis · splits 46 ⟂ 9
Hexobarbital — Overview · splits 49 ⟂ 6
Hexobarbital — History · splits 49 ⟂ 6
Hexobarbital — Reactivity · splits 50 ⟂ 5
Hexobarbital — In popular culture · splits 50 ⟂ 5
Hexobarbital — Application in research · splits 52 ⟂ 3

Map overview Semantic statistics

Hexobarbital

Nodes55
Edges54
Triples93
Avg. degree1.96
Density0.036364
Components1

Source & methodology

TTTA analyzes the structure around Hexobarbital to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Hexobarbital · EN edition · Analysis: TopicsToTalkAbout

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