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Hexobarbital

Hexobarbital or hexobarbitone, sold both in acid and sodium salt forms as Citopan, Evipan, and Tobinal, is a barbiturate derivative having hypnotic and sedative effects. It was used in the 1940s and 1950s as an agent for inducing anesthesia for surgery, as well as a rapid-acting, short-lasting hypnotic for general use, and has a relatively fast onset of…

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3D model (JSmol)
Interactive image
ATC code
N01AF02 (WHO) N05CA16 (WHO)
Boiling point
378.73 °C (713.71 °F)
CAS Number
56-29-1 Y 50-09-9 (sodium salt)
ChEBI
CHEBI:5706 Y
ChEMBL
ChEMBL7728 Y

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Application in research

Synthesis

Reactivity

Toxicity

In popular culture

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Hexobarbital

Nodes55
Edges54
Triples93
Avg. degree1.96
Density0.036364
Components1

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Hexobarbital

Top relations

related to Mechanism of actions · 16
Hexobarbital → All, AMPA, And, As, CNS-depressant, GABA, GABA-effect, GABAA, In, It, Moreover, P/Q, The, Therefore, This, When GABA
related to Metabolism · 14
Hexobarbital → AKR, All, Both, CYP2B1, HB, If, In, NAD, P450, The, These, This, UDP-glucuronosyl, UGTs
related to In popular culture · 10
Hexobarbital → Cards, Evipan, Graham Greene's The Heart, Hercule Poirot, In Agatha Christie's, It, Matter, N-methyl-cyclo-hexenyl-methyl-malonyl, Table, Veronal
related to history · 9
Hexobarbital → During World War II, Herta Oberheuser, In Hungary, Nazi, Pregnancy Category, Ravensbrück, Some, The, The FDA
related to Application in research · 6
Hexobarbital → FM, Hexobarbital Sleep Test, HST, PTSD, SM, The
related to Reactivity · 5
Hexobarbital → CYP2B1, CYP3A4, One, P450, Triacetyl
related to Synthesis · 4
Hexobarbital → Another, In, N-methylurea, This
causes · 3
Hexobarbital → an CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect, an CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect.MetabolismThe hepatic metabolism of hexobarbital, the chloride ion channel opening to their longest open state of 9 milli seconds
Legal status · 2
Hexobarbital → CA: Schedule IV, US: Schedule III
has effect · 2
Hexobarbital → Most, The

Important terminology Word statistics

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Important terminology

effects used barbiturates metabolism 3hhb hypnotic sodium cytochrome enantiomer reaction also via 3ohb use man research anesthesia effect chloride p450

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Hexobarbital3D model (JSmol)Interactive image1.00infobox
HexobarbitalATC codeN01AF02 (WHO) N05CA16 (WHO)1.00infobox
HexobarbitalBoiling point378.73 °C (713.71 °F)1.00infobox
HexobarbitalCAS Number56-29-1 Y 50-09-9 (sodium salt)1.00infobox
HexobarbitalChEBICHEBI:5706 Y1.00infobox
HexobarbitalChEMBLChEMBL7728 Y1.00infobox
HexobarbitalChemSpider3482 Y1.00infobox
HexobarbitalChiralityRacemic mixture1.00infobox
HexobarbitalCompTox Dashboard (EPA)DTXSID90231221.00infobox
HexobarbitalDensity1.1623 g/cm31.00infobox
HexobarbitalDrugBankDB01355 Y1.00infobox
HexobarbitalECHA InfoCard100.000.2411.00infobox
HexobarbitalFormulaC12H16N2O31.00infobox
HexobarbitalKEGGD01071 Y1.00infobox
HexobarbitalLegal statusCA: Schedule IV1.00infobox
HexobarbitalLegal statusUS: Schedule III1.00infobox
HexobarbitalMelting point146.5 °C (295.7 °F)1.00infobox
HexobarbitalMolar mass236.271 g·mol−11.00infobox
HexobarbitalProtein binding25%1.00infobox
HexobarbitalPubChem CID36081.00infobox
HexobarbitalSolubility in water0.435 mg/mL (20 °C)1.00infobox
HexobarbitalTrade namesHexobarbital, Hexobarbitone, Methylhexabital, Methexenyl, Evipal1.00infobox
HexobarbitalUNIIAL8Z8K3P6S1.00infobox
Hexobarbitalcausesthe chloride ion channel opening to their longest open state of 9 milli seconds0.90text
Hexobarbitalcausesan CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect.MetabolismThe hepatic metabolism of hexobarbital0.90text
Hexobarbitalcausesan CNS-depressant effect on the brain by inhibiting the glutamate release and potentiating the GABA-effect0.90text
Hexobarbitalis asubstrate0.90text

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