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Iodolactonization

Iodolactonization (or, more generally, halolactonization) is an organic reaction that forms a ring (the lactone) by the addition of an oxygen and iodine across a carbon-carbon double bond. It is an intramolecular variant of the halohydrin synthesis reaction. The reaction was first reported by M. J. Bougalt in 1904 and has since become one of the most…

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Iodolactonization

Nodes31
Edges30
Triples33
Avg. degree1.94
Density0.064516
Components1

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Iodolactonization

Top relations

related to Scope · 8
Iodolactonization → According, Baldwin's, Both, However, In, The, This, When
related to history · 6
Iodolactonization → Bougalt's, Bougalt’s, Bromolactonization, Chlorolactonization, However, The
has application · 5
Iodolactonization → Baldwin's, In, Samuel Danishefsky, The, This

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Important terminology

reaction product ring used lactone conditions synthesis synthesize addition also vibralactone bromolactonization formation formed rules coworkers double bond first many

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
vernolepininstance ofStrengths of the reaction include the mild conditions and incorporation of the versatile iodine atom into the product.Iodolactonization has been used in the synthesis of many na…0.80text
vernomenininstance ofStrengths of the reaction include the mild conditions and incorporation of the versatile iodine atom into the product.Iodolactonization has been used in the synthesis of many na…0.80text
two compounds used in tumor growth inhibitioninstance ofStrengths of the reaction include the mild conditions and incorporation of the versatile iodine atom into the product.Iodolactonization has been used in the synthesis of many na…0.80text
and vibralactoneinstance ofStrengths of the reaction include the mild conditions and incorporation of the versatile iodine atom into the product.Iodolactonization has been used in the synthesis of many na…0.80text
a pancreatic lipase inhibitorinstance ofStrengths of the reaction include the mild conditions and incorporation of the versatile iodine atom into the product.Iodolactonization has been used in the synthesis of many na…0.80text
the aforementioned vernopelininstance ofThe regioselectivity of each iodolactonization can be predicted and explained using Baldwin's rules.Stereoselective iodolactonizations have been seen in literature and can be ve…0.80text
vernomenin because the lactone can be formed while maintaining other stereocentersinstance ofThe regioselectivity of each iodolactonization can be predicted and explained using Baldwin's rules.Stereoselective iodolactonizations have been seen in literature and can be ve…0.80text
temperatureinstance ofThey were able to synthesize the cis and trans five membered lactones by adjusting reactions conditions0.80text
reaction timeinstance ofThey were able to synthesize the cis and trans five membered lactones by adjusting reactions conditions0.80text
the tumor growth inhibitors vernolepininstance ofApplicationsIodolactonization has been used in the synthesis of many biologically important products0.80text
vernomenininstance ofApplicationsIodolactonization has been used in the synthesis of many biologically important products0.80text
the pancreatic lipase inhibitor vibralactoneinstance ofApplicationsIodolactonization has been used in the synthesis of many biologically important products0.80text

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