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GNLY

Granulysin (GNLY) is a protein expressed in most mammals which functions as an antimicrobial peptide released by killer lymphocytes in cytotoxic granules. It is a pore-forming peptide, as it can puncture a microbial cell wall, allowing for other death-inducing enzymes to enter the microbe and cause microptosis. GNLY is inhibited by cholesterol, and is…

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Aliases
GNLY, 519, D2S69E, LAG-2, LAG2, NKG5, TLA519, granulysin
Available structures
Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1L9L
Band
2p11.2
Bgee
granulocyte · blood · decidua · spleen · bone marrow cell
BioGPS
More reference expression data
Chr.
Chromosome 2 (human)

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Map overview Semantic statistics

GNLY

Nodes46
Edges45
Triples67
Avg. degree1.96
Density0.043478
Components1

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GNLY

Top relations

Bgee · 10
GNLY → apex of heart, blood, bone marrow cell, decidua, granulocyte, mononuclear cell, right lobe of liver, right lung, spleen, upper lobe of left lung
RNA expression pattern · 10
GNLY → apex of heart, blood, bone marrow cell, decidua, granulocyte, mononuclear cell, right lobe of liver, right lung, spleen, upper lobe of left lung
related to Evolution · 7
GNLY → First, Generally, GNLYs, Histophilus, Mannheimia, Out, Second
related to 9 kDa GNLY · 6
GNLY → Although GNLY, However, Perforin, The, This, When
related to Gene expression · 6
GNLY → Granulysin, In, Natural Killer, NK, The, These
related to 15 kDa GNLY · 5
GNLY → Ca2, More, NK, PKC, The
Aliases · 1
GNLY → GNLY, 519, D2S69E, LAG-2, LAG2, NKG5, TLA519, granulysin
Available structures · 1
GNLY → Available structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1L9L
Band · 1
GNLY → 2p11.2
BioGPS · 1
GNLY → More reference expression data

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Important terminology

protein granulysin kda cells cytotoxic cell 15 found human granules also expressed chromosome gene expression however granzymes form immune species

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
GNLYAliasesGNLY, 519, D2S69E, LAG-2, LAG2, NKG5, TLA519, granulysin1.00infobox
GNLYAvailable structuresAvailable structuresPDBHuman UniProt search: PDBe RCSB List of PDB id codes1L9L1.00infobox
GNLYBand2p11.21.00infobox
GNLYBgeegranulocyte1.00infobox
GNLYBgeeblood1.00infobox
GNLYBgeedecidua1.00infobox
GNLYBgeespleen1.00infobox
GNLYBgeebone marrow cell1.00infobox
GNLYBgeeapex of heart1.00infobox
GNLYBgeeupper lobe of left lung1.00infobox
GNLYBgeeright lung1.00infobox
GNLYBgeeright lobe of liver1.00infobox
GNLYBgeemononuclear cell1.00infobox
GNLYBioGPSMore reference expression data1.00infobox
GNLYChr.Chromosome 2 (human)1.00infobox
GNLYDatabasesNCBI: entry; OMA: entry1.00infobox
GNLYEnd85,698,852 bp1.00infobox
GNLYEnsemblENSG000001155231.00infobox
GNLYEntrez105781.00infobox
GNLYExternal IDsOMIM: 188855; GeneCards: GNLY1.00infobox
GNLYGene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band2p11.2Start85,685,175 bpEnd85,698,852 bp1.00infobox
GNLYList of PDB id codesList of PDB id codes1L9L1.00infobox
GNLYLocation (UCSC)Chr 2: 85.69 – 85.7 Mb1.00infobox
GNLYOrthologsOrthologsDatabasesNCBI: entry; OMA: entrySpeciesHumanMouseEntrez10578n/aEnsemblENSG00000115523n/aUniProtP22749n/aRefSeq (mRNA)NM_001302758 NM_006433 NM_012483n/aRefSeq (protein)…1.00infobox
GNLYPDBHuman UniProt search: PDBe RCSB1.00infobox
GNLYRefSeq (mRNA)NM_001302758 NM_006433 NM_0124831.00infobox
GNLYRefSeq (protein)NP_001289687 NP_006424 NP_0366151.00infobox
GNLYRNA expression patterngranulocyte1.00infobox
GNLYRNA expression patternblood1.00infobox
GNLYRNA expression patterndecidua1.00infobox

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