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GFER: Structure, Clinical significance & Interactions

Growth factor, augmenter of liver regeneration (ERV1 homolog, S. cerevisiae), also known as GFER, or Hepatopoietin is a protein which in humans is encoded by the GFER gene. This gene is also known as essential for respiration and vegatative growth, augmenter of liver regeneration, and growth factor of Erv1-like/Hepatic regenerative stimulation substance.

Language: English [EN]

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GFER topic overview

The analysis highlights Structure, Clinical significance and Interactions as prominent areas in the source structure around GFER.

Related topics: 17
Source areas: 6
Connected nodes: 23
Extracted relationships: 87
Concept neighborhoods: 8
Bridge connections: 23

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 5 topics

Clinical significance · 4 topics

Interactions · 3 topics

Function · 2 topics

Overview · 2 topics

Genomics · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.8.3.2: ↗
Aliases: GFER, ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, growth factor, augmenter of liver regeneration, MMCHD, MPMCD
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3MBG, 3O55, 3TK0, 3U2L, 3U2M, 3U5S, 4LDK
Band: 16p13.3 · 17 A3.3|17 12.48 cM
Bgee: vena cava · mucosa of transverse colon · body of pancreas · muscle of thigh · olfactory zone of nasal mucosa
BioGPS: More reference expression data

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

P arm Locus (genetics)
Chromosome 16
Amino acids
Homodimer
ScERV1 ScERV1?action=edit&redlink=1

Genomics

Polycystic kidney disease

Function

Oxidative phosphorylation
Cell division cycle Cell cycle

Clinical significance

Myopathy
Cataract
Sensorineural hearing loss
Developmental delay Developmental disability

Interactions

Interact Protein-protein interaction
COP9 constitutive photomorphogenic homolog subunit 5
BNIPL

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GFER connects Entity context

The extracted context around GFER shows recurring relationship patterns in the source. For example, GFER → body of pancreas, body of tongue, embryo, epiblast, gastrocnemius muscle, granulocyte, Ileal epithelium, left lobe of liver, mucosa of transverse colon, muscle of thigh, olfactory zone of nasal mucosa, Paneth cell, primary oocyte, proximal tubule, right kidney, right lobe of liver, right testis, seminiferous tubule, triceps brachii muscle, vena cava Another extracted example is GFER → cytoplasm, cytosol, extracellular region, flavin adenine dinucleotide binding, flavin-linked sulfhydryl oxidase activity, growth factor activity, liver development, mitochondrial intermembrane space, mitochondrion, oxidoreductase activity, protein binding, protein-disulfide reductase activity, regulation of signaling receptor activity, signal transduction, thiol oxidase activity. Use these groups to spot repeated connection types before inspecting the individual relationships.

GFER

Top relations

Bgee · 20

GFER → body of pancreas, body of tongue, embryo, epiblast, gastrocnemius muscle, granulocyte, Ileal epithelium, left lobe of liver, mucosa of transverse colon, muscle of thigh, olfactory zone of nasal mucosa, Paneth cell, primary oocyte, proximal tubule, right kidney, right lobe of liver, right testis, seminiferous tubule, triceps brachii muscle, vena cava

RNA expression pattern · 20

Gene ontology · 15

GFER → cytoplasm, cytosol, extracellular region, flavin adenine dinucleotide binding, flavin-linked sulfhydryl oxidase activity, growth factor activity, liver development, mitochondrial intermembrane space, mitochondrion, oxidoreductase activity, protein binding, protein-disulfide reductase activity, regulation of signaling receptor activity, signal transduction, thiol oxidase activity

related to Clinical significance · 3

GFER → MPMCHD, Mutations, Myopathy

Band · 2

GFER → 16p13.3, 17 A3.3|17 12.48 cM

Chr. · 2

GFER → Chromosome 16 (human), Chromosome 17 (mouse)

End · 2

GFER → 1,987,749 bp, 24,915,130 bp

related to Interactions · 2

GFER → BNIPL, COP9

related to Structure · 2

GFER → The, The GFER

1.8.3.2 · 1

GFER → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp human chromosome 16 factor liver chr band growth protein augmenter regeneration scerv1 also location yeast homolog regenerative 130

GFER relationships Subject–Predicate–Object triples

TTTA extracted 87 structured relationships around GFER. Examples in this analysis include GFER → 1.8.3.2 → ↗ and GFER → Aliases → GFER, ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, growth factor, augmenter of liver regeneration, MMCHD, MPMCD. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
GFER	1.8.3.2	↗	1.00	infobox
GFER	Aliases	GFER, ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS, growth factor, augmenter of liver regeneration, MMCHD, MPMCD	1.00	infobox
GFER	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3MBG, 3O55, 3TK0, 3U2L, 3U2M, 3U5S, 4LDK	1.00	infobox
GFER	Band	16p13.3	1.00	infobox
GFER	Band	17 A3.3\|17 12.48 cM	1.00	infobox
GFER	Bgee	vena cava	1.00	infobox
GFER	Bgee	mucosa of transverse colon	1.00	infobox
GFER	Bgee	body of pancreas	1.00	infobox
GFER	Bgee	muscle of thigh	1.00	infobox
GFER	Bgee	olfactory zone of nasal mucosa	1.00	infobox
GFER	Bgee	granulocyte	1.00	infobox
GFER	Bgee	body of tongue	1.00	infobox
GFER	Bgee	right lobe of liver	1.00	infobox
GFER	Bgee	right testis	1.00	infobox
GFER	Bgee	gastrocnemius muscle	1.00	infobox
GFER	Bgee	seminiferous tubule	1.00	infobox
GFER	Bgee	primary oocyte	1.00	infobox
GFER	Bgee	Ileal epithelium	1.00	infobox
GFER	Bgee	left lobe of liver	1.00	infobox
GFER	Bgee	Paneth cell	1.00	infobox
GFER	Bgee	triceps brachii muscle	1.00	infobox
GFER	Bgee	embryo	1.00	infobox
GFER	Bgee	proximal tubule	1.00	infobox
GFER	Bgee	epiblast	1.00	infobox
GFER	Bgee	right kidney	1.00	infobox
GFER	BioGPS	More reference expression data	1.00	infobox
GFER	Chr.	Chromosome 16 (human)	1.00	infobox
GFER	Chr.	Chromosome 17 (mouse)	1.00	infobox
GFER	Databases	NCBI: entry; OMA: entry	1.00	infobox
GFER	End	1,987,749 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GFER bring nearby vocabulary together. In this analysis, examples include Growth, Liver and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

gene
- Growth
- Chromosome
- Human
- Liver
- Protein
- Gfer
- Location
- Regeneration
- Scerv1
- Yeast
- Bp
- Chr
GFER
- Growth
- Liver
- Protein
- Activity
- Function
- Gene
- Search
- Homolog
- Location
- Mitochondrial
- Regeneration
- Bp
gfer
- Growth
- Liver
- Protein
- Activity
- Function
- Gene
- Search
- Homolog
- Location
- Mitochondrial
- Regeneration
- Bp
chromosome 16
- Bp
- Human
- Location
- Band
- A3
- End
- Function
- Mouse
- Search
- Gene
- Growth
- Factor
function
- Activity
- Search
- Location
- Growth
- Bp
- Chr
- Chromosome
- Human
- Liver
- A3
- End
- Gfer
protein
- Scerv1
- Yeast
- A3
- Activity
- End
- Function
- Mouse
- Search
- Location
- Mitochondrial
- Band
- Regeneration
cop9 constitutive photomorphogenic homolog subunit 5
- Known
- Regeneration
- Scerv1
- Yeast
- Human
- Liver
- Protein
scerv1
- Yeast

Connections between topic areas Semantic bridges

For GFER, one of the stronger structural bridges in this analysis connects GFER with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

GFER — Structure · splits 18 ⟂ 6

GFER — Clinical significance · splits 19 ⟂ 5

GFER — Interactions · splits 20 ⟂ 4

GFER — Overview · splits 21 ⟂ 3

GFER — Function · splits 21 ⟂ 3

Map overview Semantic statistics

GFER

Nodes24

Edges23

Triples87

Avg. degree1.92

Density0.083333

Components1

Source & methodology

TTTA analyzes the structure around GFER to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GFER · EN edition · Analysis: TopicsToTalkAbout

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