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Gamma-secretase-activating protein: Gene, Therapeutic target for Alzheimer's disease & Protein

Gamma-secretase-activating protein, also known as Protein pigeon homolog (PION) is a protein that in humans is encoded by the GSAP gene.

Language: English [EN]
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Gamma-secretase-activating protein topic overview

The analysis highlights Gene, Therapeutic target for Alzheimer's disease and Protein as prominent areas in the source structure around Gamma-secretase-activating protein.

Related topics
20
Source areas
6
Connected nodes
26
Extracted relationships
62
Related term clusters
15
Bridge connections
26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Gene · 6 topics
Therapeutic target for Alzheimer's disease · 4 topics
Function · 3 topics
Protein · 3 topics
Discovery · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GSAP, PION, Protein pigeon homolog, gamma-secretase activating protein
Band
7q11.23 · 5|5 A3
Bgee
granulocyte · right uterine tube · monocyte · spleen · right lung
BioGPS
n/a
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Function

Therapeutic target for Alzheimer's disease

Discovery

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Gamma-secretase-activating protein connects Entity context

The extracted context around Gamma-secretase-activating protein shows recurring relationship patterns in the source. For example, Gamma-secretase-activating protein → epithelium of nasopharynx, granulocyte, left lobe of liver, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lobe of thyroid gland, right lung, right lung lobe, right uterine tube, Rostral migratory stream, secondary oocyte, spermatid, spleen, tibiofemoral joint, upper lobe of left lung, visceral pleura Another extracted example is Gamma-secretase-activating protein → amyloid-beta binding, Golgi apparatus, positive regulation of amyloid-beta formation, protein binding, regulation of proteolysis, trans-Golgi network. Use these groups to spot repeated connection types before inspecting the individual relationships.

Gamma-secretase-activating protein

Top relations

Bgee · 18
Gamma-secretase-activating protein → epithelium of nasopharynx, granulocyte, left lobe of liver, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lobe of thyroid gland, right lung, right lung lobe, right uterine tube, Rostral migratory stream, secondary oocyte, spermatid, spleen, tibiofemoral joint, upper lobe of left lung, visceral pleura
RNA expression pattern · 18
Gamma-secretase-activating protein → epithelium of nasopharynx, granulocyte, left lobe of liver, lumbar spinal ganglion, monocyte, proximal tubule, right kidney, right lobe of thyroid gland, right lung, right lung lobe, right uterine tube, Rostral migratory stream, secondary oocyte, spermatid, spleen, tibiofemoral joint, upper lobe of left lung, visceral pleura
Gene ontology · 6
Gamma-secretase-activating protein → amyloid-beta binding, Golgi apparatus, positive regulation of amyloid-beta formation, protein binding, regulation of proteolysis, trans-Golgi network
Band · 2
Gamma-secretase-activating protein → 5|5 A3, 7q11.23
Chr. · 2
Gamma-secretase-activating protein → Chromosome 5 (mouse), Chromosome 7 (human)
End · 2
Gamma-secretase-activating protein → 21,520,130 bp, 77,416,349 bp
Aliases · 1
Gamma-secretase-activating protein → GSAP, PION, Protein pigeon homolog, gamma-secretase activating protein
BioGPS · 1
Gamma-secretase-activating protein → n/a
Databases · 1
Gamma-secretase-activating protein → NCBI: entry; OMA: entry
Ensembl · 1
Gamma-secretase-activating protein → ENSG00000186088

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene gsap γ-secretase human protein bp pion band chr function chromosome imatinib pigeon β-amyloid activating homolog location orthologs also known

Gamma-secretase-activating protein relationships Subject–Predicate–Object triples

TTTA extracted 62 structured relationships around Gamma-secretase-activating protein. Examples in this analysis include Gamma-secretase-activating protein → Aliases → GSAP, PION, Protein pigeon homolog, gamma-secretase activating protein and Gamma-secretase-activating protein → Band → 7q11.23. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Gamma-secretase-activating proteinAliasesGSAP, PION, Protein pigeon homolog, gamma-secretase activating protein1.00infobox
Gamma-secretase-activating proteinBand7q11.231.00infobox
Gamma-secretase-activating proteinBand5|5 A31.00infobox
Gamma-secretase-activating proteinBgeegranulocyte1.00infobox
Gamma-secretase-activating proteinBgeeright uterine tube1.00infobox
Gamma-secretase-activating proteinBgeemonocyte1.00infobox
Gamma-secretase-activating proteinBgeespleen1.00infobox
Gamma-secretase-activating proteinBgeeright lung1.00infobox
Gamma-secretase-activating proteinBgeeepithelium of nasopharynx1.00infobox
Gamma-secretase-activating proteinBgeevisceral pleura1.00infobox
Gamma-secretase-activating proteinBgeeright lobe of thyroid gland1.00infobox
Gamma-secretase-activating proteinBgeesecondary oocyte1.00infobox
Gamma-secretase-activating proteinBgeeupper lobe of left lung1.00infobox
Gamma-secretase-activating proteinBgeelumbar spinal ganglion1.00infobox
Gamma-secretase-activating proteinBgeespermatid1.00infobox
Gamma-secretase-activating proteinBgeeright lung lobe1.00infobox
Gamma-secretase-activating proteinBgeeright kidney1.00infobox
Gamma-secretase-activating proteinBgeeRostral migratory stream1.00infobox
Gamma-secretase-activating proteinBgeeleft lobe of liver1.00infobox
Gamma-secretase-activating proteinBgeetibiofemoral joint1.00infobox
Gamma-secretase-activating proteinBgeeproximal tubule1.00infobox
Gamma-secretase-activating proteinBioGPSn/a1.00infobox
Gamma-secretase-activating proteinChr.Chromosome 7 (human)1.00infobox
Gamma-secretase-activating proteinChr.Chromosome 5 (mouse)1.00infobox
Gamma-secretase-activating proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Gamma-secretase-activating proteinEnd77,416,349 bp1.00infobox
Gamma-secretase-activating proteinEnd21,520,130 bp1.00infobox
Gamma-secretase-activating proteinEnsemblENSG000001860881.00infobox
Gamma-secretase-activating proteinEntrez541031.00infobox
Gamma-secretase-activating proteinExternal IDsOMIM: 613552; MGI: 2442259; GeneCards: GSAP1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Gamma-secretase-activating protein bring nearby vocabulary together. In this analysis, examples include Human, Location and End. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Pion
    • Human
    • Location
    • Chromosome
    • Pigeon
    • Bp
    • Chr
    • Protein
    • Function
    • End
    • Expressed
    • Mouse
  • cognitive function
    • Gsap
    • Pion
    • Activating
    • Location
    • Gene
    • Γ-secretase
    • Chromosome
    • Bp
    • Chr
    • Imatinib
    • Protein
    • Human
  • function
    • Gsap
    • Pion
    • Activating
    • Location
    • Gene
    • Γ-secretase
    • Chromosome
    • Bp
    • Chr
    • Imatinib
    • Protein
    • Human
  • therapeutic target for alzheimer's disease
    • Disease
    • Alzheimer's
    • Target
    • Therapeutic
    • Activating
    • Homolog
    • Location
    • Gsap
    • Chromosome
    • Drug
    • May
    • Pigeon
  • chromosome 7
    • Bp
    • Location
    • Human
    • Band
    • End
    • Mouse
    • Gene
    • Protein
    • Function
    • Pion
    • Disease
    • Expressed
  • alzheimer's disease
    • Disease
    • Target
    • Therapeutic
    • Activating
    • Homolog
    • Location
    • Gsap
    • Chromosome
    • Pigeon
    • Bp
    • Chr
    • Protein
  • γ-secretase
    • Gsap
    • App
    • Drug
    • Semagacestat
    • Β-amyloid
    • Imatinib
    • Function
    • Activating
    • May
    • Also
    • Formation
    • Known
  • Gamma-secretase-activating protein
    • Human
    • Location
    • End
    • Expressed
    • Mouse
    • App
    • Formation
    • Orthologs
    • Target
    • Therapeutic
    • Band
    • Β-amyloid

Connections between topic areas Semantic bridges

For Gamma-secretase-activating protein, one of the stronger structural bridges in this analysis connects Gamma-secretase-activating protein with Gene. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Gamma-secretase-activating protein — Gene · splits 20 ⟂ 7
Gamma-secretase-activating protein — Therapeutic target for Alzheimer's disease · splits 22 ⟂ 5
Gamma-secretase-activating protein — Protein · splits 23 ⟂ 4
Gamma-secretase-activating protein — Function · splits 23 ⟂ 4
Gamma-secretase-activating protein — Overview · splits 24 ⟂ 3
Gamma-secretase-activating protein — Discovery · splits 24 ⟂ 3

Map overview Semantic statistics

Gamma-secretase-activating protein

Nodes27
Edges26
Triples62
Avg. degree1.93
Density0.074074
Components1

Source & methodology

TTTA analyzes the structure around Gamma-secretase-activating protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Gene, Therapeutic target for Alzheimer's disease & Protein, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Gamma-secretase-activating protein · EN edition · Analysis: TopicsToTalkAbout

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