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Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.
The analysis highlights Role in disease, Structure and function and Overview as prominent areas in the source structure around FOXC2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around FOXC2 shows recurring relationship patterns in the source. For example, FOXC2 → anatomical structure morphogenesis, artery morphogenesis, blood vessel development, blood vessel remodeling, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell population proliferation, chromatin DNA binding, collagen fibril organization, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic heart tube development, embryonic skeletal system morphogenesis, embryonic viscerocranium morphogenesis Another extracted example is FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp gene chr human band transcription chromosome 16 box also protein expression development location differentiation fork head cancer mouse involved
TTTA extracted 142 structured relationships around FOXC2. Examples in this analysis include FOXC2 → Aliases → FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2 and FOXC2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| FOXC2 | Aliases | FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2 | 1.00 | infobox |
| FOXC2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V | 1.00 | infobox |
| FOXC2 | Band | 16q24.1 | 1.00 | infobox |
| FOXC2 | Band | 8 E1|8 70.33 cM | 1.00 | infobox |
| FOXC2 | Bgee | vena cava | 1.00 | infobox |
| FOXC2 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| FOXC2 | Bgee | popliteal artery | 1.00 | infobox |
| FOXC2 | Bgee | trigeminal ganglion | 1.00 | infobox |
| FOXC2 | Bgee | tibial arteries | 1.00 | infobox |
| FOXC2 | Bgee | urethra | 1.00 | infobox |
| FOXC2 | Bgee | ascending aorta | 1.00 | infobox |
| FOXC2 | Bgee | spinal ganglia | 1.00 | infobox |
| FOXC2 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| FOXC2 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| FOXC2 | Bgee | aortic arches | 1.00 | infobox |
| FOXC2 | Bgee | fifth metatarsal bone | 1.00 | infobox |
| FOXC2 | Bgee | renal corpuscle | 1.00 | infobox |
| FOXC2 | Bgee | optic nerve | 1.00 | infobox |
| FOXC2 | Bgee | aortic valve | 1.00 | infobox |
| FOXC2 | Bgee | fourth metatarsal bone | 1.00 | infobox |
| FOXC2 | Bgee | somite | 1.00 | infobox |
| FOXC2 | Bgee | sclerotome | 1.00 | infobox |
| FOXC2 | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| FOXC2 | BioGPS | n/a | 1.00 | infobox |
| FOXC2 | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| FOXC2 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| FOXC2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| FOXC2 | End | 86,569,728 bp | 1.00 | infobox |
| FOXC2 | End | 121,845,634 bp | 1.00 | infobox |
| FOXC2 | Ensembl | ENSG00000176692 | 1.00 | infobox |
The concept neighborhoods around FOXC2 bring nearby vocabulary together. In this analysis, examples include Expression, Gene and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For FOXC2, one of the stronger structural bridges in this analysis connects FOXC2 with Role in disease. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around FOXC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in disease, Structure and function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — FOXC2 · EN edition · Analysis: TopicsToTalkAbout