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Research this topic
Explore the main themes, entities and connections around FOXC2. Start with the topic map, then use the sections below for research and deeper semantic analysis.
Explore this topic
Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Role in disease
12 related topics
Structure and function
5 related topics
Overview
5 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- Aliases
- FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V
- Band
- 16q24.1 · 8 E1|8 70.33 cM
- Bgee
- vena cava · palpebral conjunctiva · popliteal artery · trigeminal ganglion · tibial arteries
- BioGPS
- n/a
- Chr.
- Chromosome 16 (human) · Chromosome 8 (mouse)
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Mesenchyme
- Protein
- Gene
- Fork head box FOX proteins
- Transcription factors Transcription factor
Structure and function
- Introns
- Exon
- Differentiation Cellular differentiation
- Podocytes Podocyte
- Glomerular basement membrane
Role in disease
- Lymphedema–distichiasis syndrome
- Cancer
- Metastases
- Epithelial cells Epithelium
- Epithelial-mesenchymal transition
- Mesenchymal Mesenchymal stem cell
- Snail SNAI1
- Twist Twist transcription factor
- Goosecoid GSC (gene)
- TGF-beta 1 TGF beta 1
- ShRNA Small hairpin RNA
- Breast cancer
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.FOXC2
Nodes26
Edges25
Triples142
Avg. degree1.92
Density0.076923
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
FOXC2
Top relations
Gene ontology · 66
FOXC2 → anatomical structure morphogenesis, artery morphogenesis, blood vessel development, blood vessel remodeling, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell population proliferation, chromatin DNA binding, collagen fibril organization, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic heart tube development, embryonic skeletal system morphogenesis, embryonic viscerocranium morphogenesis
Bgee · 19
FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava
RNA expression pattern · 19
FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava
related to Role in disease · 11
FOXC2 → Absence, EMT, Goosecoid, In, It, Lymphedema, Overexpression, Snail, Suppression, TGF-beta, Twist
related to Structure and function · 3
FOXC2 → FOX, It, The
Band · 2
FOXC2 → 16q24.1, 8 E1|8 70.33 cM
Chr. · 2
FOXC2 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
FOXC2 → 121,845,634 bp, 86,569,728 bp
Aliases · 1
FOXC2 → FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
Available structures · 1
FOXC2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
bp gene chr human band transcription chromosome 16 box also protein expression development location differentiation fork head cancer mouse involved
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| FOXC2 | Aliases | FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2 | 1.00 | infobox |
| FOXC2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V | 1.00 | infobox |
| FOXC2 | Band | 16q24.1 | 1.00 | infobox |
| FOXC2 | Band | 8 E1|8 70.33 cM | 1.00 | infobox |
| FOXC2 | Bgee | vena cava | 1.00 | infobox |
| FOXC2 | Bgee | palpebral conjunctiva | 1.00 | infobox |
| FOXC2 | Bgee | popliteal artery | 1.00 | infobox |
| FOXC2 | Bgee | trigeminal ganglion | 1.00 | infobox |
| FOXC2 | Bgee | tibial arteries | 1.00 | infobox |
| FOXC2 | Bgee | urethra | 1.00 | infobox |
| FOXC2 | Bgee | ascending aorta | 1.00 | infobox |
| FOXC2 | Bgee | spinal ganglia | 1.00 | infobox |
| FOXC2 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| FOXC2 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| FOXC2 | Bgee | aortic arches | 1.00 | infobox |
| FOXC2 | Bgee | fifth metatarsal bone | 1.00 | infobox |
| FOXC2 | Bgee | renal corpuscle | 1.00 | infobox |
| FOXC2 | Bgee | optic nerve | 1.00 | infobox |
| FOXC2 | Bgee | aortic valve | 1.00 | infobox |
| FOXC2 | Bgee | fourth metatarsal bone | 1.00 | infobox |
| FOXC2 | Bgee | somite | 1.00 | infobox |
| FOXC2 | Bgee | sclerotome | 1.00 | infobox |
| FOXC2 | Bgee | lumbar spinal ganglion | 1.00 | infobox |
| FOXC2 | BioGPS | n/a | 1.00 | infobox |
| FOXC2 | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| FOXC2 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| FOXC2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| FOXC2 | End | 86,569,728 bp | 1.00 | infobox |
| FOXC2 | End | 121,845,634 bp | 1.00 | infobox |
| FOXC2 | Ensembl | ENSG00000176692 | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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