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FOXC2: Role in disease, Structure and function & Overview

Forkhead box protein C2 (FOXC2) also known as forkhead-related protein FKHL14 (FKHL14), transcription factor FKH-14, or mesenchyme fork head protein 1 (MFH1) is a protein that in humans is encoded by the FOXC2 gene. FOXC2 is a member of the fork head box (FOX) family of transcription factors.

Language: English [EN]
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FOXC2 topic overview

The analysis highlights Role in disease, Structure and function and Overview as prominent areas in the source structure around FOXC2.

Related topics
22
Source areas
3
Connected nodes
25
Extracted relationships
142
Concept neighborhoods
10
Bridge connections
25

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in disease · 12 topics
Overview · 5 topics
Structure and function · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V
Band
16q24.1 · 8 E1|8 70.33 cM
Bgee
vena cava · palpebral conjunctiva · popliteal artery · trigeminal ganglion · tibial arteries
BioGPS
n/a
Chr.
Chromosome 16 (human) · Chromosome 8 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure and function

Role in disease

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FOXC2 connects Entity context

The extracted context around FOXC2 shows recurring relationship patterns in the source. For example, FOXC2 → anatomical structure morphogenesis, artery morphogenesis, blood vessel development, blood vessel remodeling, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell population proliferation, chromatin DNA binding, collagen fibril organization, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic heart tube development, embryonic skeletal system morphogenesis, embryonic viscerocranium morphogenesis Another extracted example is FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

FOXC2

Top relations

Gene ontology · 66
FOXC2 → anatomical structure morphogenesis, artery morphogenesis, blood vessel development, blood vessel remodeling, branching involved in blood vessel morphogenesis, camera-type eye development, cardiac muscle cell proliferation, cell differentiation, cell population proliferation, chromatin DNA binding, collagen fibril organization, development of the heart, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, embryonic cranial skeleton morphogenesis, embryonic heart tube development, embryonic skeletal system morphogenesis, embryonic viscerocranium morphogenesis
Bgee · 19
FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava
RNA expression pattern · 19
FOXC2 → aortic arches, aortic valve, ascending aorta, cardiac muscle tissue of right atrium, Descending thoracic aorta, fifth metatarsal bone, fourth metatarsal bone, lumbar spinal ganglion, optic nerve, palpebral conjunctiva, popliteal artery, renal corpuscle, sclerotome, somite, spinal ganglia, tibial arteries, trigeminal ganglion, urethra, vena cava
related to Role in disease · 11
FOXC2 → Absence, EMT, Goosecoid, In, It, Lymphedema, Overexpression, Snail, Suppression, TGF-beta, Twist
related to Structure and function · 3
FOXC2 → FOX, It, The
Band · 2
FOXC2 → 16q24.1, 8 E1|8 70.33 cM
Chr. · 2
FOXC2 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
FOXC2 → 121,845,634 bp, 86,569,728 bp
Aliases · 1
FOXC2 → FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2
Available structures · 1
FOXC2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band transcription chromosome 16 box also protein expression development location differentiation fork head cancer mouse involved

FOXC2 relationships Subject–Predicate–Object triples

TTTA extracted 142 structured relationships around FOXC2. Examples in this analysis include FOXC2 → Aliases → FOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C2 and FOXC2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FOXC2AliasesFOXC2, FKHL14, LD, MFH-1, MFH1, forkhead box C21.00infobox
FOXC2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1D5V1.00infobox
FOXC2Band16q24.11.00infobox
FOXC2Band8 E1|8 70.33 cM1.00infobox
FOXC2Bgeevena cava1.00infobox
FOXC2Bgeepalpebral conjunctiva1.00infobox
FOXC2Bgeepopliteal artery1.00infobox
FOXC2Bgeetrigeminal ganglion1.00infobox
FOXC2Bgeetibial arteries1.00infobox
FOXC2Bgeeurethra1.00infobox
FOXC2Bgeeascending aorta1.00infobox
FOXC2Bgeespinal ganglia1.00infobox
FOXC2BgeeDescending thoracic aorta1.00infobox
FOXC2Bgeecardiac muscle tissue of right atrium1.00infobox
FOXC2Bgeeaortic arches1.00infobox
FOXC2Bgeefifth metatarsal bone1.00infobox
FOXC2Bgeerenal corpuscle1.00infobox
FOXC2Bgeeoptic nerve1.00infobox
FOXC2Bgeeaortic valve1.00infobox
FOXC2Bgeefourth metatarsal bone1.00infobox
FOXC2Bgeesomite1.00infobox
FOXC2Bgeesclerotome1.00infobox
FOXC2Bgeelumbar spinal ganglion1.00infobox
FOXC2BioGPSn/a1.00infobox
FOXC2Chr.Chromosome 16 (human)1.00infobox
FOXC2Chr.Chromosome 8 (mouse)1.00infobox
FOXC2DatabasesNCBI: entry; OMA: entry1.00infobox
FOXC2End86,569,728 bp1.00infobox
FOXC2End121,845,634 bp1.00infobox
FOXC2EnsemblENSG000001766921.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FOXC2 bring nearby vocabulary together. In this analysis, examples include Expression, Gene and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FOXC2
    • Expression
    • Gene
    • Cancer
    • Transcription
    • Function
    • Head
    • Mfh1
    • Protein
    • Search
    • Structure
    • Differentiation
    • Involved
  • foxc2
    • Expression
    • Gene
    • Cancer
    • Transcription
    • Function
    • Head
    • Mfh1
    • Protein
    • Search
    • Structure
    • Differentiation
    • Involved
  • transcription factors
    • Fox
    • Factor
    • Factors
    • Fork
    • Head
    • Protein
    • Transcription
    • Box
    • Differentiation
    • Development
    • Gene
    • Number
  • fork head box
    • Head
    • C2
    • Fkhl14
    • Fork
    • Forkhead
    • Mfh1
    • Transcription
    • External
    • Factors
    • Fox
    • Protein
    • Gene
  • gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • E1
    • End
    • Function
    • Mfh1
    • Mouse
    • Protein
    • Search
  • protein
    • Transcription
    • E1
    • End
    • Function
    • Gene
    • Head
    • Mfh1
    • Mouse
    • Search
    • Structure
    • Differentiation
    • Involved
  • structure and function
    • Search
    • Structure
    • Location
    • Chromosome
    • External
    • Human
    • Bp
    • Chr
    • E1
    • End
    • Gene
    • Mfh1
  • differentiation
    • Transcription
    • E1
    • End
    • Factor
    • Factors
    • Fox
    • Function
    • Mouse
    • Protein
    • Search
    • Structure
    • Involved

Connections between topic areas Semantic bridges

For FOXC2, one of the stronger structural bridges in this analysis connects FOXC2 with Role in disease. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FOXC2Role in disease · splits 13 ⟂ 13
FOXC2Overview · splits 20 ⟂ 6
FOXC2Structure and function · splits 20 ⟂ 6

Map overview Semantic statistics

FOXC2

Nodes26
Edges25
Triples142
Avg. degree1.92
Density0.076923
Components1

Source & methodology

TTTA analyzes the structure around FOXC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Role in disease, Structure and function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FOXC2 · EN edition · Analysis: TopicsToTalkAbout

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