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Fibronectin type III domain-containing protein 5, the precursor of irisin, is a type I transmembrane glycoprotein that is encoded by the FNDC5 gene. Irisin is a cleaved version of FNDC5, named after the Greek messenger goddess Iris.
The analysis highlights History, Biosynthesis and secretion and Function as prominent areas in the source structure around FNDC5.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around FNDC5 shows recurring relationship patterns in the source. For example, FNDC5 → apex of heart, cardiac muscle tissue of right atrium, cerebellar cortex, deep cerebellar nuclei, deltoid muscle, digastric muscle, extraocular muscle, gastrocnemius muscle, interventricular septum, medial vestibular nucleus, muscle of thigh, myocardium of ventricle, primary visual cortex, right hemisphere of cerebellum, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, superior frontal gyrus, tibialis anterior muscle, vastus lateralis muscle Another extracted example is FNDC5 → biological process, endoplasmic reticulum, extracellular region, hormone activity, integral component of membrane, membrane, molecular function, peroxisomal membrane, peroxisome, plasma membrane, positive regulation of brown fat cell differentiation, regulation of signaling receptor activity, response to muscle activity, signal transduction. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
irisin human protein expression type exercise bp gene fibronectin iii chr band study levels bdnf fat humans cells chromosome membrane
TTTA extracted 110 structured relationships around FNDC5. Examples in this analysis include FNDC5 → Aliases → FNDC5, FRCP2, irisin, Irisin, fibronectin type III domain containing 5 and FNDC5 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4LSD. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| FNDC5 | Aliases | FNDC5, FRCP2, irisin, Irisin, fibronectin type III domain containing 5 | 1.00 | infobox |
| FNDC5 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4LSD | 1.00 | infobox |
| FNDC5 | Band | 1p35.1 | 1.00 | infobox |
| FNDC5 | Band | 4|4 D2.2 | 1.00 | infobox |
| FNDC5 | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| FNDC5 | Bgee | muscle of thigh | 1.00 | infobox |
| FNDC5 | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| FNDC5 | Bgee | vastus lateralis muscle | 1.00 | infobox |
| FNDC5 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| FNDC5 | Bgee | gastrocnemius muscle | 1.00 | infobox |
| FNDC5 | Bgee | apex of heart | 1.00 | infobox |
| FNDC5 | Bgee | deltoid muscle | 1.00 | infobox |
| FNDC5 | Bgee | cardiac muscle tissue of right atrium | 1.00 | infobox |
| FNDC5 | Bgee | tibialis anterior muscle | 1.00 | infobox |
| FNDC5 | Bgee | interventricular septum | 1.00 | infobox |
| FNDC5 | Bgee | myocardium of ventricle | 1.00 | infobox |
| FNDC5 | Bgee | cerebellar cortex | 1.00 | infobox |
| FNDC5 | Bgee | soleus muscle | 1.00 | infobox |
| FNDC5 | Bgee | extraocular muscle | 1.00 | infobox |
| FNDC5 | Bgee | medial vestibular nucleus | 1.00 | infobox |
| FNDC5 | Bgee | deep cerebellar nuclei | 1.00 | infobox |
| FNDC5 | Bgee | superior frontal gyrus | 1.00 | infobox |
| FNDC5 | Bgee | digastric muscle | 1.00 | infobox |
| FNDC5 | Bgee | primary visual cortex | 1.00 | infobox |
| FNDC5 | BioGPS | n/a | 1.00 | infobox |
| FNDC5 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| FNDC5 | Chr. | Chromosome 4 (mouse) | 1.00 | infobox |
| FNDC5 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| FNDC5 | End | 32,872,482 bp | 1.00 | infobox |
| FNDC5 | End | 129,038,386 bp | 1.00 | infobox |
The concept neighborhoods around FNDC5 bring nearby vocabulary together. In this analysis, examples include Irisin, Protein and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For FNDC5, one of the stronger structural bridges in this analysis connects FNDC5 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around FNDC5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Biosynthesis and secretion & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — FNDC5 · EN edition · Analysis: TopicsToTalkAbout