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Fibroblast growth factor 1: Interactions, Function & Overview

Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others…

Language: English [EN]
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Fibroblast growth factor 1 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around Fibroblast growth factor 1.

Related topics
31
Source areas
3
Connected nodes
34
Extracted relationships
114
Concept neighborhoods
14
Bridge connections
34

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 14 topics
Interactions · 10 topics
Function · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16,…
Band
5q31.3 · 18 B3|18 20.74 cM
Bgee
glomerulus · metanephric glomerulus · inferior ganglion of vagus nerve · corpus callosum · optic nerve
BioGPS
More reference expression data
Chr.
Chromosome 5 (human) · Chromosome 18 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Fibroblast growth factor 1 connects Entity context

The extracted context around Fibroblast growth factor 1 shows recurring relationship patterns in the source. For example, Fibroblast growth factor 1 → 1-phosphatidylinositol-3-kinase activity, activation of protein kinase B activity, anatomical structure morphogenesis, angiogenesis, branch elongation involved in ureteric bud branching, cell cortex, cell differentiation, cell population proliferation, cellular response to heat, cytoplasm, cytosol, extracellular matrix, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, heparin binding, Hsp70 protein binding, integrin binding Another extracted example is Fibroblast growth factor 1 → anterior horn of spinal cord, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, facial motor nucleus, glomerulus, habenula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, medial vestibular nucleus, medulla oblongata, metanephric glomerulus, myocardium of ventricle, olfactory bulb, optic nerve, pontine nuclei, right lung, right ventricle. Use these groups to spot repeated connection types before inspecting the individual relationships.

Fibroblast growth factor 1

Top relations

Gene ontology · 51
Fibroblast growth factor 1 → 1-phosphatidylinositol-3-kinase activity, activation of protein kinase B activity, anatomical structure morphogenesis, angiogenesis, branch elongation involved in ureteric bud branching, cell cortex, cell differentiation, cell population proliferation, cellular response to heat, cytoplasm, cytosol, extracellular matrix, extracellular region, extracellular space, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, heparin binding, Hsp70 protein binding, integrin binding
Bgee · 20
Fibroblast growth factor 1 → anterior horn of spinal cord, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, facial motor nucleus, glomerulus, habenula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, medial vestibular nucleus, medulla oblongata, metanephric glomerulus, myocardium of ventricle, olfactory bulb, optic nerve, pontine nuclei, right lung, right ventricle
RNA expression pattern · 20
Fibroblast growth factor 1 → anterior horn of spinal cord, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, external globus pallidus, facial motor nucleus, glomerulus, habenula, inferior ganglion of vagus nerve, inferior olivary nucleus, internal globus pallidus, medial vestibular nucleus, medulla oblongata, metanephric glomerulus, myocardium of ventricle, olfactory bulb, optic nerve, pontine nuclei, right lung, right ventricle
Band · 2
Fibroblast growth factor 1 → 18 B3|18 20.74 cM, 5q31.3
Chr. · 2
Fibroblast growth factor 1 → Chromosome 18 (mouse), Chromosome 5 (human)
End · 2
Fibroblast growth factor 1 → 142,698,070 bp, 39,062,525 bp
Aliases · 1
Fibroblast growth factor 1 → FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1
Available structures · 1
Fibroblast growth factor 1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16,…
BioGPS · 1
Fibroblast growth factor 1 → More reference expression data
Databases · 1
Fibroblast growth factor 1 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fgf1 protein growth factor cell fibroblast gene bp also chr human band chromosome proteins nucleus fgf-1 binding extracellular receptor function

Fibroblast growth factor 1 relationships Subject–Predicate–Object triples

TTTA extracted 114 structured relationships around Fibroblast growth factor 1. Examples in this analysis include Fibroblast growth factor 1 → Aliases → FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1 and Fibroblast growth factor 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Fibroblast growth factor 1AliasesFGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 11.00infobox
Fibroblast growth factor 1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO3, 1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16,…1.00infobox
Fibroblast growth factor 1Band5q31.31.00infobox
Fibroblast growth factor 1Band18 B3|18 20.74 cM1.00infobox
Fibroblast growth factor 1Bgeeglomerulus1.00infobox
Fibroblast growth factor 1Bgeemetanephric glomerulus1.00infobox
Fibroblast growth factor 1Bgeeinferior ganglion of vagus nerve1.00infobox
Fibroblast growth factor 1Bgeecorpus callosum1.00infobox
Fibroblast growth factor 1Bgeeoptic nerve1.00infobox
Fibroblast growth factor 1Bgeeexternal globus pallidus1.00infobox
Fibroblast growth factor 1Bgeeinternal globus pallidus1.00infobox
Fibroblast growth factor 1Bgeemedulla oblongata1.00infobox
Fibroblast growth factor 1Bgeeinferior olivary nucleus1.00infobox
Fibroblast growth factor 1Bgeeolfactory bulb1.00infobox
Fibroblast growth factor 1Bgeedeep cerebellar nuclei1.00infobox
Fibroblast growth factor 1Bgeepontine nuclei1.00infobox
Fibroblast growth factor 1Bgeemedial vestibular nucleus1.00infobox
Fibroblast growth factor 1Bgeehabenula1.00infobox
Fibroblast growth factor 1Bgeefacial motor nucleus1.00infobox
Fibroblast growth factor 1Bgeedorsal tegmental nucleus1.00infobox
Fibroblast growth factor 1Bgeeanterior horn of spinal cord1.00infobox
Fibroblast growth factor 1Bgeeright lung1.00infobox
Fibroblast growth factor 1Bgeemyocardium of ventricle1.00infobox
Fibroblast growth factor 1Bgeeright ventricle1.00infobox
Fibroblast growth factor 1BioGPSMore reference expression data1.00infobox
Fibroblast growth factor 1Chr.Chromosome 5 (human)1.00infobox
Fibroblast growth factor 1Chr.Chromosome 18 (mouse)1.00infobox
Fibroblast growth factor 1DatabasesNCBI: entry; OMA: entry1.00infobox
Fibroblast growth factor 1End142,698,070 bp1.00infobox
Fibroblast growth factor 1End39,062,525 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Fibroblast growth factor 1 bring nearby vocabulary together. In this analysis, examples include Growth, Factor and Fibroblast. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Fibroblast growth factor 1
    • Growth
    • Factor
    • Fibroblast
    • Fgf1
    • Protein
    • Gene
    • Acidic
    • Afgf
    • Cell
    • Signaling
    • Also
    • Different
  • fibroblast growth factor 1
    • Growth
    • Factor
    • Fibroblast
    • Gene
    • Fgf1
    • Protein
    • Family
    • Fgf
    • Cell
    • Endothelial
    • Acidic
    • Afgf
  • growth factor
    • Growth
    • Fibroblast
    • Gene
    • Fgf1
    • Protein
    • Family
    • Fgf
    • Cell
    • Endothelial
    • Signaling
    • Acidic
    • Afgf
  • signaling protein
    • Cell
    • Gene
    • Endothelial
    • Nucleus
    • Acidic
    • Afgf
    • Fibroblast
    • Involved
    • Matrix
    • Mouse
    • Signal
    • Growth
  • gene
    • Location
    • Chromosome
    • Growth
    • Human
    • Bp
    • Chr
    • Mouse
    • Signaling
    • Family
    • Fgf
    • Function
    • Nucleus
  • family of fgf
    • Endothelial
    • Family
    • Fgf
    • Proteins
    • Receptor
    • Growth
    • Gene
    • Cell
    • Fibroblast
    • Fgf1
    • Involved
    • Matrix
  • endothelial cell growth factor-1
    • Protein
    • Cell
    • Endothelial
    • Fgf
    • Gene
    • Nucleus
    • Family
    • Factor
    • Fgfrs
    • Fibroblast
    • Nuclear
    • Sequence
  • fibroblast growth factor receptor (fgfr)
    • Growth
    • Factor
    • Fibroblast
    • Gene
    • Fgf1
    • Protein
    • Family
    • Fgf
    • Cell
    • Endothelial
    • Acidic
    • Afgf

Connections between topic areas Semantic bridges

For Fibroblast growth factor 1, one of the stronger structural bridges in this analysis connects Fibroblast growth factor 1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Fibroblast growth factor 1Overview · splits 20 ⟂ 15
Fibroblast growth factor 1Interactions · splits 24 ⟂ 11
Fibroblast growth factor 1Function · splits 27 ⟂ 8

Map overview Semantic statistics

Fibroblast growth factor 1

Nodes35
Edges34
Triples114
Avg. degree1.94
Density0.057143
Components1

Source & methodology

TTTA analyzes the structure around Fibroblast growth factor 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Fibroblast growth factor 1 · EN edition · Analysis: TopicsToTalkAbout

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