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Eosinophil cationic protein: Measurement, Clinical significance & Function

Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. In humans, the eosinophil cationic protein is encoded by the RNASE3 gene.

Language: English [EN]
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Eosinophil cationic protein topic overview

The analysis highlights Measurement, Clinical significance and Function as prominent areas in the source structure around Eosinophil cationic protein.

Related topics
28
Source areas
5
Connected nodes
33
Extracted relationships
64
Concept neighborhoods
16
Bridge connections
33

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 12 topics
Function · 6 topics
Overview · 4 topics
Ribonuclease activity and cytotoxicity · 4 topics
ECP-induced apoptosis · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y
Band
14q11.2
Bgee
trabecular bone · bone marrow · bone marrow cell · testicle · mononuclear cell
BioGPS
n/a
Chr.
Chromosome 14 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Ribonuclease activity and cytotoxicity

ECP-induced apoptosis

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Eosinophil cationic protein connects Entity context

The extracted context around Eosinophil cationic protein shows recurring relationship patterns in the source. For example, Eosinophil cationic protein → antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, azurophil granule lumen, defense response to bacterium, endonuclease activity, extracellular region, extracellular space, hydrolase activity, innate immune response, innate immune response in mucosa, lipopolysaccharide binding, neutrophil degranulation, nuclease activity, nucleic acid binding, nucleic acid phosphodiester bond hydrolysis, ribonuclease activity, RNA catabolic process, RNA phosphodiester bond hydrolysis Another extracted example is Eosinophil cationic protein → blood, bone marrow, bone marrow cell, gonad, granulocyte, monocyte, mononuclear cell, spleen, testicle, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Eosinophil cationic protein

Top relations

Gene ontology · 18
Eosinophil cationic protein → antimicrobial humoral immune response mediated by antimicrobial peptide, antimicrobial humoral response, azurophil granule lumen, defense response to bacterium, endonuclease activity, extracellular region, extracellular space, hydrolase activity, innate immune response, innate immune response in mucosa, lipopolysaccharide binding, neutrophil degranulation, nuclease activity, nucleic acid binding, nucleic acid phosphodiester bond hydrolysis, ribonuclease activity, RNA catabolic process, RNA phosphodiester bond hydrolysis
Bgee · 10
Eosinophil cationic protein → blood, bone marrow, bone marrow cell, gonad, granulocyte, monocyte, mononuclear cell, spleen, testicle, trabecular bone
RNA expression pattern · 10
Eosinophil cationic protein → blood, bone marrow, bone marrow cell, gonad, granulocyte, monocyte, mononuclear cell, spleen, testicle, trabecular bone
related to Function · 4
Eosinophil cationic protein → Both, Eosinophil, Ribonuclease, RNASE2
Aliases · 1
Eosinophil cationic protein → RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3
Available structures · 1
Eosinophil cationic protein → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y
Band · 1
Eosinophil cationic protein → 14q11.2
BioGPS · 1
Eosinophil cationic protein → n/a
Chr. · 1
Eosinophil cationic protein → Chromosome 14 (human)
Databases · 1
Eosinophil cationic protein → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ecp protein ribonuclease eosinophil activity also human apoptosis cells cationic eosinophils rnase3 asthma cell bp gene levels cytotoxicity chr chromosome

Eosinophil cationic protein relationships Subject–Predicate–Object triples

TTTA extracted 64 structured relationships around Eosinophil cationic protein. Examples in this analysis include Eosinophil cationic protein → Aliases → RNASE3, ECP, RNS3, RAF1, ribonuclease A family member 3 and Eosinophil cationic protein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Eosinophil cationic proteinAliasesRNASE3, ECP, RNS3, RAF1, ribonuclease A family member 31.00infobox
Eosinophil cationic proteinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4A2O, 4X08, 1DYT, 4OXB, 2LVZ, 2KB5, 4OXF, 1QMT, 4OWZ, 1H1H, 4A2Y1.00infobox
Eosinophil cationic proteinBand14q11.21.00infobox
Eosinophil cationic proteinBgeetrabecular bone1.00infobox
Eosinophil cationic proteinBgeebone marrow1.00infobox
Eosinophil cationic proteinBgeebone marrow cell1.00infobox
Eosinophil cationic proteinBgeetesticle1.00infobox
Eosinophil cationic proteinBgeemononuclear cell1.00infobox
Eosinophil cationic proteinBgeemonocyte1.00infobox
Eosinophil cationic proteinBgeeblood1.00infobox
Eosinophil cationic proteinBgeegranulocyte1.00infobox
Eosinophil cationic proteinBgeespleen1.00infobox
Eosinophil cationic proteinBgeegonad1.00infobox
Eosinophil cationic proteinBioGPSn/a1.00infobox
Eosinophil cationic proteinChr.Chromosome 14 (human)1.00infobox
Eosinophil cationic proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Eosinophil cationic proteinEnd20,892,348 bp1.00infobox
Eosinophil cationic proteinEnsemblENSG000001693971.00infobox
Eosinophil cationic proteinEntrez60371.00infobox
Eosinophil cationic proteinExternal IDsOMIM: 131398; MGI: 3528616; GeneCards: RNASE31.00infobox
Eosinophil cationic proteinGene location (Human)Gene location (Human)Chr.Chromosome 14 (human)Band14q11.2Start20,891,385 bpEnd20,892,348 bp1.00infobox
Eosinophil cationic proteinGene ontologynuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyendonuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyribonuclease activity1.00infobox
Eosinophil cationic proteinGene ontologyhydrolase activity1.00infobox
Eosinophil cationic proteinGene ontologynucleic acid binding1.00infobox
Eosinophil cationic proteinGene ontologylipopolysaccharide binding1.00infobox
Eosinophil cationic proteinGene ontologyextracellular region1.00infobox
Eosinophil cationic proteinGene ontologyextracellular space1.00infobox
Eosinophil cationic proteinGene ontologyazurophil granule lumen1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Eosinophil cationic protein bring nearby vocabulary together. In this analysis, examples include Eosinophil, Protein and Ribonuclease. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Eosinophil cationic protein
    • Eosinophil
    • Protein
    • Ribonuclease
    • Gene
    • Granule
    • Rnase3
    • Band
    • Basic
    • Degranulation
    • Function
    • Known
    • Molecular
  • eosinophil cationic protein
    • Eosinophil
    • Protein
    • Ribonuclease
    • Rnase3
    • Gene
    • Granule
    • Human
    • Band
    • Basic
    • Degranulation
    • Function
    • Known
  • ribonuclease activity and cytotoxicity
    • Ribonuclease
    • Cytotoxicity
    • Ecp
    • External
    • Two
    • Function
    • Rnase3
    • Bp
    • Chr
    • Chromosome
    • Gene
    • Known
  • eosinophil
    • Protein
    • Ribonuclease
    • Gene
    • Granule
    • Rnase3
    • Band
    • Basic
    • Degranulation
    • Function
    • Known
    • Molecular
    • Bp
  • eosinophil granulocytes
    • Protein
    • Ribonuclease
    • Gene
    • Granule
    • Rnase3
    • Band
    • Basic
    • Degranulation
    • Function
    • Known
    • Molecular
    • Bp
  • gene
    • Rnase3
    • Function
    • Bp
    • Chr
    • Chromosome
    • External
    • Human
    • Band
    • Degranulation
    • Molecular
    • Ribonuclease
    • Activity
  • apoptosis
    • Studies
    • Epithelial
    • Human
    • Cells
    • External
    • Ecp
    • Function
    • Bp
    • Bronchial
    • Chr
    • Chromosome
    • Clinical
  • ecp-induced apoptosis
    • Studies
    • Epithelial
    • Human
    • Cells
    • External
    • Ecp
    • Function
    • Bp
    • Bronchial
    • Chr
    • Chromosome
    • Clinical

Connections between topic areas Semantic bridges

For Eosinophil cationic protein, one of the stronger structural bridges in this analysis connects Eosinophil cationic protein with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Eosinophil cationic proteinClinical significance · splits 21 ⟂ 13
Eosinophil cationic proteinFunction · splits 27 ⟂ 7
Eosinophil cationic proteinOverview · splits 29 ⟂ 5
Eosinophil cationic proteinRibonuclease activity and cytotoxicity · splits 29 ⟂ 5
Eosinophil cationic proteinECP-induced apoptosis · splits 31 ⟂ 3

Map overview Semantic statistics

Eosinophil cationic protein

Nodes34
Edges33
Triples64
Avg. degree1.94
Density0.058824
Components1

Source & methodology

TTTA analyzes the structure around Eosinophil cationic protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Eosinophil cationic protein · EN edition · Analysis: TopicsToTalkAbout

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