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Iodotyrosine deiodinase

Iodotyrosine deiodinase, also known as iodotyrosine dehalogenase 1, is a type of deiodinase enzyme that scavenges iodide by removing it from iodinated tyrosine residues in the thyroid gland. These iodinated tyrosines are produced during thyroid hormone biosynthesis. The iodide that is scavenged by iodotyrosine deiodinase is necessary to again synthesize…

Structure, Function & Clinical significance

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Structure

GeneMammalsMembrane proteinN-terminusDimer
7 related topics

Function

MonoDiiodotyrosineHomeostasisThyroglobulin
4 related topics

Clinical significance

HypothyroidismGoiterUrineCongenital
4 related topics

Overview

DeiodinaseEnzymeIodideTyrosineThyroid
13 related topics

Key facts & relationships

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BRENDA
enzyme data
EC no.
1.21.1.1
ExPASy
NiceZyme view
KEGG
enzyme entry
MetaCyc
metabolic pathway
NCBI
proteins

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Overview

Structure

Function

Mechanism

  • NADPH Nicotinamide adenine dinucleotide phosphate

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Iodotyrosine deiodinase

Nodes35
Edges34
Triples61
Avg. degree1.94
Density0.057143
Components1

How this topic connects Entity context

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Iodotyrosine deiodinase

Top relations

related to External links · 16
Iodotyrosine deiodinase → Deiodinase, Human Iodotyrosine, Iodotyrosine, Medicine, Medicine Medical Subject Headings, MeSH, Mouse Iodotyrosine, National Library, Overview, PDB, PDBe-KB, Q6PHW0, Q9DCX8, This, UniProt, United States National Library
related to Structure · 10
Iodotyrosine deiodinase → FMN, Initially, Iodotyrosine, It, N-terminus, NADH, Substrate, The, Thus, Within
related to Clinical significance · 9
Iodotyrosine deiodinase → Because, Furthermore, However, In, Iodide, Low, Mutations, The, To
related to Function · 7
Iodotyrosine deiodinase → However, Iodide, Iodotyrosine, The, Thus, Within, Without
related to Mechanism · 7
Iodotyrosine deiodinase → Although, Flavin, FMN, Iodotyrosine, It, NADPH-dependent, The
BRENDA · 1
Iodotyrosine deiodinase → enzyme data
EC no. · 1
Iodotyrosine deiodinase → 1.21.1.1
ExPASy · 1
Iodotyrosine deiodinase → NiceZyme view
KEGG · 1
Iodotyrosine deiodinase → enzyme entry
MetaCyc · 1
Iodotyrosine deiodinase → metabolic pathway

Important terminology Word statistics

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Important terminology

iodotyrosine deiodinase thyroid iodide enzyme hormones hormone flavin iodinated two also diiodotyrosine mono- tyrosines however known dehalogenation reductive iodothyronine catalysis

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Iodotyrosine deiodinaseBRENDAenzyme data1.00infobox
Iodotyrosine deiodinaseEC no.1.21.1.11.00infobox
Iodotyrosine deiodinaseExPASyNiceZyme view1.00infobox
Iodotyrosine deiodinaseKEGGenzyme entry1.00infobox
Iodotyrosine deiodinaseMetaCycmetabolic pathway1.00infobox
Iodotyrosine deiodinaseNCBIproteins1.00infobox
Iodotyrosine deiodinasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Iodotyrosine deiodinasePMCarticles1.00infobox
Iodotyrosine deiodinasePubMedarticles1.00infobox
Iodotyrosine deiodinaseRheareactions1.00infobox
Iodotyrosine deiodinaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox
Iodotyrosine deiodinaseis amembrane protein0.90text

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