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Dynamin-like 120 kDa protein: Interactions, Clinical significance & Structure

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, and small, round mitochondria. Mutations in this gene have been implicated in dominant optic…

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Dynamin-like 120 kDa protein topic overview

The analysis highlights Interactions, Clinical significance and Structure as prominent areas in the source structure around Dynamin-like 120 kDa protein.

Related topics: 21
Source areas: 5
Connected nodes: 26
Extracted relationships: 125
Concept neighborhoods: 13
Bridge connections: 26

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 6 topics

Clinical significance · 5 topics

Overview · 4 topics

Function · 3 topics

Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.5: ↗
Aliases: OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase
Band: 3q29 · 16 B2|16 20.65 cM
Bgee: Achilles tendon · endothelial cell · secondary oocyte · lateral nuclear group of thalamus · Brodmann area 23
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 16 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Optic atrophy type 1 Optic neuropathy
Dominant optic atrophy (DOA) Kjer's optic neuropathy
Ophthalmoplegia Ophthalmoparesis
Parkinson's disease
Antisense oligonucleotide Antisense therapy

Interactions

Adenonucleotide transporters Adenonucleotide transporter?action=edit&redlink=1
ATP synthase
CHCHD3 CHCHD3?action=edit&redlink=1
Mitofilin IMMT
Prohibitin
SAMM50

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dynamin-like 120 kDa protein connects Entity context

The extracted context around Dynamin-like 120 kDa protein shows recurring relationship patterns in the source. For example, Dynamin-like 120 kDa protein → ageing, apoptotic process, axon cytoplasm, axonal transport of mitochondrion, calcium import into the mitochondrion, cardiolipin binding, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to L-glutamate, cellular senescence, cochlea development, cytoplasm, cytosol, dendrite, dynamin family protein polymerization involved in mitochondrial fission, extrinsic component of mitochondrial inner membrane, GTP binding, GTP metabolic process, GTPase activity, hydrolase activity Another extracted example is Dynamin-like 120 kDa protein → Achilles tendon, Brodmann area 23, dorsal striatum, endothelial cell, lateral nuclear group of thalamus, medial vestibular nucleus, middle temporal gyrus, monocyte, myocardium of ventricle, nucleus accumbens, olfactory tubercle, pontine nuclei, rectum, Region I of hippocampus proper, right ventricle, secondary oocyte, subiculum, substantia nigra, superior frontal gyrus, temporal lobe. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dynamin-like 120 kDa protein

Top relations

Gene ontology · 63

Dynamin-like 120 kDa protein → ageing, apoptotic process, axon cytoplasm, axonal transport of mitochondrion, calcium import into the mitochondrion, cardiolipin binding, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to L-glutamate, cellular senescence, cochlea development, cytoplasm, cytosol, dendrite, dynamin family protein polymerization involved in mitochondrial fission, extrinsic component of mitochondrial inner membrane, GTP binding, GTP metabolic process, GTPase activity, hydrolase activity

Bgee · 20

Dynamin-like 120 kDa protein → Achilles tendon, Brodmann area 23, dorsal striatum, endothelial cell, lateral nuclear group of thalamus, medial vestibular nucleus, middle temporal gyrus, monocyte, myocardium of ventricle, nucleus accumbens, olfactory tubercle, pontine nuclei, rectum, Region I of hippocampus proper, right ventricle, secondary oocyte, subiculum, substantia nigra, superior frontal gyrus, temporal lobe

RNA expression pattern · 20

Band · 2

Dynamin-like 120 kDa protein → 16 B2|16 20.65 cM, 3q29

Chr. · 2

Dynamin-like 120 kDa protein → Chromosome 16 (mouse), Chromosome 3 (human)

End · 2

Dynamin-like 120 kDa protein → 193,697,811 bp, 29,473,702 bp

3.6.5.5 · 1

Dynamin-like 120 kDa protein → ↗

Aliases · 1

Dynamin-like 120 kDa protein → OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase

BioGPS · 1

Dynamin-like 120 kDa protein → More reference expression data

Databases · 1

Dynamin-like 120 kDa protein → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mitochondrial opa1 gene protein bp fusion chr cristae human band optic atrophy leading chromosome membrane structure mutations loss oligomerization inner

Dynamin-like 120 kDa protein relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around Dynamin-like 120 kDa protein. Examples in this analysis include Dynamin-like 120 kDa protein → 3.6.5.5 → ↗ and Dynamin-like 120 kDa protein → Aliases → OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Dynamin-like 120 kDa protein	3.6.5.5	↗	1.00	infobox
Dynamin-like 120 kDa protein	Aliases	OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase	1.00	infobox
Dynamin-like 120 kDa protein	Band	3q29	1.00	infobox
Dynamin-like 120 kDa protein	Band	16 B2\|16 20.65 cM	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	Achilles tendon	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	endothelial cell	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	secondary oocyte	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	lateral nuclear group of thalamus	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	Brodmann area 23	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	middle temporal gyrus	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	right ventricle	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	monocyte	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	rectum	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	superior frontal gyrus	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	dorsal striatum	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	olfactory tubercle	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	nucleus accumbens	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	pontine nuclei	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	temporal lobe	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	Region I of hippocampus proper	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	subiculum	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	medial vestibular nucleus	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	myocardium of ventricle	1.00	infobox
Dynamin-like 120 kDa protein	Bgee	substantia nigra	1.00	infobox
Dynamin-like 120 kDa protein	BioGPS	More reference expression data	1.00	infobox
Dynamin-like 120 kDa protein	Chr.	Chromosome 3 (human)	1.00	infobox
Dynamin-like 120 kDa protein	Chr.	Chromosome 16 (mouse)	1.00	infobox
Dynamin-like 120 kDa protein	Databases	NCBI: entry; OMA: entry	1.00	infobox
Dynamin-like 120 kDa protein	End	193,697,811 bp	1.00	infobox
Dynamin-like 120 kDa protein	End	29,473,702 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dynamin-like 120 kDa protein bring nearby vocabulary together. In this analysis, examples include Fusion, Inner and Membrane. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Dynamin-like 120 kDa protein
- Fusion
- Inner
- Membrane
- Structure
- Cristae
- Mitochondria
- Regulates
- Exon
- Levels
- Transcript
- Two
- Oligomerization
dynamin-like 120 kda protein
- Fusion
- Inner
- Membrane
- Structure
- Cristae
- Mitochondria
- Regulates
- Exon
- Levels
- Transcript
- Two
- Oligomerization
protein
- Fusion
- Inner
- Membrane
- Structure
- Cristae
- Mitochondria
- Regulates
- Exon
- Levels
- Transcript
- Two
- Oligomerization
gene
- Location
- Chromosome
- Human
- Atrophy
- Bp
- Chr
- Optic
- Mouse
- Muscle
- Protein
- Activity
- Function
inner mitochondrial membrane
- Membrane
- Mitochondria
- Regulates
- Opa1
- Imm
- Protein
- Cristae
- Fusion
- Structure
- Two
- Mitochondrial
- Oligomerization
outer mitochondrial membrane
- Opa1
- Imm
- Mitochondria
- Regulates
- Cristae
- Fusion
- Two
- Protein
- Structure
- Membrane
- Mitochondrial
- Oligomerization
function
- Activity
- Gtpase
- Location
- Chromosome
- Human
- Bp
- Chr
- External
- Gene
- Mitochondria
- Mouse
- Muscle
optic atrophy type 1
- Optic
- Neuropathy
- Loss
- Mutations
- Leading
- External
- Doa
- Gene
- Gtpase
- Hearing
- Muscle
- Activity

Connections between topic areas Semantic bridges

For Dynamin-like 120 kDa protein, one of the stronger structural bridges in this analysis connects Dynamin-like 120 kDa protein with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Dynamin-like 120 kDa protein — Interactions · splits 20 ⟂ 7

Dynamin-like 120 kDa protein — Clinical significance · splits 21 ⟂ 6

Dynamin-like 120 kDa protein — Overview · splits 22 ⟂ 5

Dynamin-like 120 kDa protein — Structure · splits 23 ⟂ 4

Dynamin-like 120 kDa protein — Function · splits 23 ⟂ 4

Map overview Semantic statistics

Dynamin-like 120 kDa protein

Nodes27

Edges26

Triples125

Avg. degree1.93

Density0.074074

Components1

Source & methodology

TTTA analyzes the structure around Dynamin-like 120 kDa protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dynamin-like 120 kDa protein · EN edition · Analysis: TopicsToTalkAbout

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