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Dynamin-like 120 kDa protein: Clinical significance, Interactions & Structure

Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis, and small, round mitochondria. Mutations in this gene have been implicated in dominant optic…

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Dynamin-like 120 kDa protein topic overview

The analysis highlights Clinical significance, Interactions and Structure as prominent areas in the source structure around Dynamin-like 120 kDa protein.

Related topics
19
Source areas
5
Connected nodes
24
Extracted relationships
125
Related term clusters
13
Bridge connections
24

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 5 topics
Interactions · 4 topics
Overview · 4 topics
Function · 3 topics
Structure · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.6.5.5
↗
Aliases
OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase
Band
3q29 · 16 B2|16 20.65 cM
Bgee
Achilles tendon · endothelial cell · secondary oocyte · lateral nuclear group of thalamus · Brodmann area 23
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 16 (mouse)

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Dynamin-like 120 kDa protein connects Entity context

The extracted context around Dynamin-like 120 kDa protein shows recurring relationship patterns in the source. For example, Dynamin-like 120 kDa protein → ageing, apoptotic process, axon cytoplasm, axonal transport of mitochondrion, calcium import into the mitochondrion, cardiolipin binding, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to L-glutamate, cellular senescence, cochlea development, cytoplasm, cytosol, dendrite, dynamin family protein polymerization involved in mitochondrial fission, extrinsic component of mitochondrial inner membrane, GTP binding, GTP metabolic process, GTPase activity, hydrolase activity Another extracted example is Dynamin-like 120 kDa protein → Achilles tendon, Brodmann area 23, dorsal striatum, endothelial cell, lateral nuclear group of thalamus, medial vestibular nucleus, middle temporal gyrus, monocyte, myocardium of ventricle, nucleus accumbens, olfactory tubercle, pontine nuclei, rectum, Region I of hippocampus proper, right ventricle, secondary oocyte, subiculum, substantia nigra, superior frontal gyrus, temporal lobe. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dynamin-like 120 kDa protein

Top relations

Gene ontology · 63
Dynamin-like 120 kDa protein → ageing, apoptotic process, axon cytoplasm, axonal transport of mitochondrion, calcium import into the mitochondrion, cardiolipin binding, cellular response to glucose stimulus, cellular response to hypoxia, cellular response to L-glutamate, cellular senescence, cochlea development, cytoplasm, cytosol, dendrite, dynamin family protein polymerization involved in mitochondrial fission, extrinsic component of mitochondrial inner membrane, GTP binding, GTP metabolic process, GTPase activity, hydrolase activity
Bgee · 20
Dynamin-like 120 kDa protein → Achilles tendon, Brodmann area 23, dorsal striatum, endothelial cell, lateral nuclear group of thalamus, medial vestibular nucleus, middle temporal gyrus, monocyte, myocardium of ventricle, nucleus accumbens, olfactory tubercle, pontine nuclei, rectum, Region I of hippocampus proper, right ventricle, secondary oocyte, subiculum, substantia nigra, superior frontal gyrus, temporal lobe
RNA expression pattern · 20
Dynamin-like 120 kDa protein → Achilles tendon, Brodmann area 23, dorsal striatum, endothelial cell, lateral nuclear group of thalamus, medial vestibular nucleus, middle temporal gyrus, monocyte, myocardium of ventricle, nucleus accumbens, olfactory tubercle, pontine nuclei, rectum, Region I of hippocampus proper, right ventricle, secondary oocyte, subiculum, substantia nigra, superior frontal gyrus, temporal lobe
Band · 2
Dynamin-like 120 kDa protein → 16 B2|16 20.65 cM, 3q29
Chr. · 2
Dynamin-like 120 kDa protein → Chromosome 16 (mouse), Chromosome 3 (human)
End · 2
Dynamin-like 120 kDa protein → 193,697,811 bp, 29,473,702 bp
3.6.5.5 · 1
Dynamin-like 120 kDa protein → ↗
Aliases · 1
Dynamin-like 120 kDa protein → OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase
BioGPS · 1
Dynamin-like 120 kDa protein → More reference expression data
Databases · 1
Dynamin-like 120 kDa protein → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

mitochondrial opa1 gene protein bp fusion chr cristae human band optic atrophy leading chromosome membrane structure mutations loss oligomerization inner

Dynamin-like 120 kDa protein relationships Subject–Predicate–Object triples

TTTA extracted 125 structured relationships around Dynamin-like 120 kDa protein. Examples in this analysis include Dynamin-like 120 kDa protein → 3.6.5.5 → ↗ and Dynamin-like 120 kDa protein → Aliases → OPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dynamin-like 120 kDa protein3.6.5.5↗1.00infobox
Dynamin-like 120 kDa proteinAliasesOPA1, MGM1, NPG, NTG, largeG, Optic atrophy 1, BERHS, MTDPS14, mitochondrial dynamin like GTPase, OPA1 mitochondrial dynamin like GTPase1.00infobox
Dynamin-like 120 kDa proteinBand3q291.00infobox
Dynamin-like 120 kDa proteinBand16 B2|16 20.65 cM1.00infobox
Dynamin-like 120 kDa proteinBgeeAchilles tendon1.00infobox
Dynamin-like 120 kDa proteinBgeeendothelial cell1.00infobox
Dynamin-like 120 kDa proteinBgeesecondary oocyte1.00infobox
Dynamin-like 120 kDa proteinBgeelateral nuclear group of thalamus1.00infobox
Dynamin-like 120 kDa proteinBgeeBrodmann area 231.00infobox
Dynamin-like 120 kDa proteinBgeemiddle temporal gyrus1.00infobox
Dynamin-like 120 kDa proteinBgeeright ventricle1.00infobox
Dynamin-like 120 kDa proteinBgeemonocyte1.00infobox
Dynamin-like 120 kDa proteinBgeerectum1.00infobox
Dynamin-like 120 kDa proteinBgeesuperior frontal gyrus1.00infobox
Dynamin-like 120 kDa proteinBgeedorsal striatum1.00infobox
Dynamin-like 120 kDa proteinBgeeolfactory tubercle1.00infobox
Dynamin-like 120 kDa proteinBgeenucleus accumbens1.00infobox
Dynamin-like 120 kDa proteinBgeepontine nuclei1.00infobox
Dynamin-like 120 kDa proteinBgeetemporal lobe1.00infobox
Dynamin-like 120 kDa proteinBgeeRegion I of hippocampus proper1.00infobox
Dynamin-like 120 kDa proteinBgeesubiculum1.00infobox
Dynamin-like 120 kDa proteinBgeemedial vestibular nucleus1.00infobox
Dynamin-like 120 kDa proteinBgeemyocardium of ventricle1.00infobox
Dynamin-like 120 kDa proteinBgeesubstantia nigra1.00infobox
Dynamin-like 120 kDa proteinBioGPSMore reference expression data1.00infobox
Dynamin-like 120 kDa proteinChr.Chromosome 3 (human)1.00infobox
Dynamin-like 120 kDa proteinChr.Chromosome 16 (mouse)1.00infobox
Dynamin-like 120 kDa proteinDatabasesNCBI: entry; OMA: entry1.00infobox
Dynamin-like 120 kDa proteinEnd193,697,811 bp1.00infobox
Dynamin-like 120 kDa proteinEnd29,473,702 bp1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Dynamin-like 120 kDa protein bring nearby vocabulary together. In this analysis, examples include Fusion, Inner and Membrane. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dynamin-like 120 kDa protein
    • Fusion
    • Inner
    • Membrane
    • Structure
    • Cristae
    • Mitochondria
    • Regulates
    • Exon
    • Levels
    • Transcript
    • Two
    • Oligomerization
  • dynamin-like 120 kda protein
    • Fusion
    • Inner
    • Membrane
    • Structure
    • Cristae
    • Mitochondria
    • Regulates
    • Exon
    • Levels
    • Transcript
    • Two
    • Oligomerization
  • protein
    • Fusion
    • Inner
    • Membrane
    • Structure
    • Cristae
    • Mitochondria
    • Regulates
    • Exon
    • Levels
    • Transcript
    • Two
    • Oligomerization
  • gene
    • Location
    • Chromosome
    • Human
    • Atrophy
    • Bp
    • Chr
    • Optic
    • Mouse
    • Muscle
    • Protein
    • Activity
    • Function
  • inner mitochondrial membrane
    • Membrane
    • Mitochondria
    • Regulates
    • Opa1
    • Imm
    • Protein
    • Cristae
    • Fusion
    • Structure
    • Two
    • Mitochondrial
    • Oligomerization
  • outer mitochondrial membrane
    • Opa1
    • Imm
    • Mitochondria
    • Regulates
    • Cristae
    • Fusion
    • Two
    • Protein
    • Structure
    • Membrane
    • Mitochondrial
    • Oligomerization
  • function
    • Activity
    • Gtpase
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • External
    • Gene
    • Mitochondria
    • Mouse
    • Muscle
  • optic atrophy type 1
    • Optic
    • Neuropathy
    • Loss
    • Mutations
    • Leading
    • External
    • Doa
    • Gene
    • Gtpase
    • Hearing
    • Muscle
    • Activity

Connections between topic areas Semantic bridges

For Dynamin-like 120 kDa protein, one of the stronger structural bridges in this analysis connects Dynamin-like 120 kDa protein with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dynamin-like 120 kDa protein — Clinical significance · splits 19 ⟂ 6
Dynamin-like 120 kDa protein — Overview · splits 20 ⟂ 5
Dynamin-like 120 kDa protein — Interactions · splits 20 ⟂ 5
Dynamin-like 120 kDa protein — Structure · splits 21 ⟂ 4
Dynamin-like 120 kDa protein — Function · splits 21 ⟂ 4

Map overview Semantic statistics

Dynamin-like 120 kDa protein

Nodes25
Edges24
Triples125
Avg. degree1.92
Density0.08
Components1

Source & methodology

TTTA analyzes the structure around Dynamin-like 120 kDa protein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dynamin-like 120 kDa protein · EN edition · Analysis: TopicsToTalkAbout

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