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Disopyramide

Disopyramide (INN, trade names Norpace and Rythmodan) is an antiarrhythmic medication used in the treatment of ventricular tachycardia. It is a sodium channel blocker and is classified as a Class 1a anti-arrhythmic agent. Disopyramide has a negative inotropic effect on the ventricular myocardium, significantly decreasing the contractility. Disopyramide…

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C01BA03 (WHO)
Bioavailability
High
CAS Number
3737-09-5 Y
ChEBI
CHEBI:4657 Y

Topics to explore

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Overview

Obstructive hypertrophic cardiomyopathy

Side effects

Adverse effects

Advanced semantic analysis

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Map overview Semantic statistics

Disopyramide

Nodes39
Edges38
Triples70
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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Disopyramide

Top relations

related to Obstructive hypertrophic cardiomyopathy · 15
Disopyramide → American Heart Association/American College, Beta-blockers, Cardiology Foundation, Disopyramide's, HCM, Hypertrophic, IB, It, LV, Many, Negative, Pharmacologic, The, United States, When
has effect · 9
Disopyramide → Acute, ConstipationBlurred, Dry, GlaucomaAgranulocytosis, Heart, Hypotension, LV, Severe, Urinary
related to Mechanism of action · 9
Disopyramide → Anesthetized, AV, Disopyramide's Class, Levites, Phase, PR, QRS, SA, This
Legal status · 3
Disopyramide → BR: Class C1 (Other controlled substances), UK: POM (Prescription only), US: ℞-only
3D model (JSmol) · 1
Disopyramide → Interactive image
AHFS/Drugs.com · 1
Disopyramide → Monograph
ATC code · 1
Disopyramide → C01BA03 (WHO)
Bioavailability · 1
Disopyramide → High
CAS Number · 1
Disopyramide → 3737-09-5 Y
ChEBI · 1
Disopyramide → CHEBI:4657 Y

Important terminology Word statistics

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Important terminology

effects patients ventricular used side lv treatment negative effect antiarrhythmic normal inotropic hcm systolic agent quinidine action obstructive also class

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Disopyramide3D model (JSmol)Interactive image1.00infobox
DisopyramideAHFS/Drugs.comMonograph1.00infobox
DisopyramideATC codeC01BA03 (WHO)1.00infobox
DisopyramideBioavailabilityHigh1.00infobox
DisopyramideCAS Number3737-09-5 Y1.00infobox
DisopyramideChEBICHEBI:4657 Y1.00infobox
DisopyramideChEMBLChEMBL517 Y1.00infobox
DisopyramideChemSpider3002 Y1.00infobox
DisopyramideCompTox Dashboard (EPA)DTXSID10455361.00infobox
DisopyramideDrugBankDB00280 Y1.00infobox
DisopyramideECHA InfoCard100.021.0101.00infobox
DisopyramideElimination half-life6.7 hours (range 4 to 10 hours)1.00infobox
DisopyramideExcretionRenal (80%)1.00infobox
DisopyramideFormulaC21H29N3O1.00infobox
DisopyramideIUPHAR/BPS71671.00infobox
DisopyramideKEGGD00303 Y1.00infobox
DisopyramideLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DisopyramideLegal statusUK: POM (Prescription only)1.00infobox
DisopyramideLegal statusUS: ℞-only1.00infobox
DisopyramideMedlinePlusa6824081.00infobox
DisopyramideMelting point94.5 to 95 °C (202.1 to 203.0 °F)1.00infobox
DisopyramideMetabolismHepatic (CYP3A4-mediated)1.00infobox
DisopyramideMolar mass339.483 g·mol−11.00infobox
DisopyramidePregnancy categoryAU: B21.00infobox
DisopyramideProtein binding50% to 65% (concentration-dependent)1.00infobox
DisopyramidePubChem CID31141.00infobox
DisopyramideRoutes of administrationOral, intravenous1.00infobox
DisopyramideTrade namesNorpace1.00infobox
DisopyramideUNIIGFO928U8MQ1.00infobox
Disopyramideis areasonable approach before proceeding to invasive septal reduction0.90text

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