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Dornase alfa

Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis. It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA. Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions. It is produced in Chinese…

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Society and culture

Orphan drug
1 related topics

Medical uses

Indicated
1 related topics

Research

Atelectasis
1 related topics

Overview

Cystic fibrosisDeoxyribonuclease IEnzymeDNAViscosity
6 related topics

Key facts & relationships

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AHFS/Drugs.com
Monograph
ATC code
R05CB13 (WHO)
CAS Number
143831-71-4 N
ChemSpider
none
CompTox Dashboard (EPA)
DTXSID801010888
DrugBank
DB00003 Y

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Overview

Medical uses

Society and culture

Research

Advanced semantic analysis

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Map overview Semantic statistics

Dornase alfa

Nodes14
Edges13
Triples34
Avg. degree1.86
Density0.142857
Components1

How this topic connects Entity context

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Dornase alfa

Top relations

related to Production · 5
Dornase alfa → Chinese, CHO, DNA, DNase, The FDA
Legal status · 4
Dornase alfa → AU: S4 (Prescription only), CA: ℞-only / Schedule D, In general: ℞ (Prescription only), US: ℞-only
related to Medical uses · 4
Dornase alfa → Cochrane, Dornase, FEV1, Rash
related to Mechanism of action · 3
Dornase alfa → DNA, DNase, Dornase
AHFS/Drugs.com · 1
Dornase alfa → Monograph
ATC code · 1
Dornase alfa → R05CB13 (WHO)
CAS Number · 1
Dornase alfa → 143831-71-4 N
ChemSpider · 1
Dornase alfa → none
CompTox Dashboard (EPA) · 1
Dornase alfa → DTXSID801010888
DrugBank · 1
Dornase alfa → DB00003 Y

Important terminology Word statistics

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Important terminology

dornase alfa dna fibrosis cystic human pulmozyme viscosity legal status function recombinant selectively cleaves sputum mucus reduces clearance secretions produced

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dornase alfaAHFS/Drugs.comMonograph1.00infobox
Dornase alfaATC codeR05CB13 (WHO)1.00infobox
Dornase alfaCAS Number143831-71-4 N1.00infobox
Dornase alfaChemSpidernone1.00infobox
Dornase alfaCompTox Dashboard (EPA)DTXSID8010108881.00infobox
Dornase alfaDrugBankDB00003 Y1.00infobox
Dornase alfaECHA InfoCard100.029.6851.00infobox
Dornase alfaFormulaC1321H1999N339O396S91.00infobox
Dornase alfaKEGGD038961.00infobox
Dornase alfaLegal statusAU: S4 (Prescription only)1.00infobox
Dornase alfaLegal statusCA: ℞-only / Schedule D1.00infobox
Dornase alfaLegal statusUS: ℞-only1.00infobox
Dornase alfaLegal statusIn general: ℞ (Prescription only)1.00infobox
Dornase alfaLicense dataUS DailyMed: Dornase alfa1.00infobox
Dornase alfaMedlinePlusa6940021.00infobox
Dornase alfaMolar mass29254.04 g·mol−11.00infobox
Dornase alfaPregnancy categoryAU: B11.00infobox
Dornase alfaRoutes of administrationInhalation1.00infobox
Dornase alfaTrade namesPulmozyme1.00infobox
Dornase alfaUNII953A26OA1Y1.00infobox

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