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Cripto

Cripto is an EGF-CFC or epidermal growth factor-CFC, which is encoded by the Cryptic family 1 gene. Cryptic family protein 1B is a protein that in humans is encoded by the CFC1B gene. Cryptic family protein 1B acts as a receptor for the TGF beta signaling pathway. It has been associated with the translation of an extracellular protein for this pathway.…

Structure, Clinical significance & Expression during embryonic development

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Structure

CysteineCFCN-terminalC-terminalHydrophobic
5 related topics

Clinical significance

OncogeneEmbryonic stem cellsCardiomyocyteNeuronalEGFR inhibitors
5 related topics

Expression during embryonic development

MesodermEmbryonic death
2 related topics

The role in cancer

Epithelial-to-mesenchymal transitionWnt signaling pathway
2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
CFC1B, entrez:653275, cripto, FRL-1, cryptic family 1B
Band
2q21.1 · 1|1 B
Bgee
gonad · islet of Langerhans · prefrontal cortex · rectum · right adrenal cortex
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Structure

Expression during embryonic development

The role in cancer

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Cripto

Nodes23
Edges22
Triples111
Avg. degree1.91
Density0.086957
Components1

How this topic connects Entity context

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Cripto

Top relations

Bgee · 19
Cripto → blastocyst, condyle, duodenum, embryo, embryonic organizer, epiblast, gastrula, gonad, islet of Langerhans, lateral plate mesoderm, mesoderm, morula, muscle tissue, olfactory zone of nasal mucosa, prefrontal cortex, rectum, right adrenal cortex, superior frontal gyrus, urinary bladder
RNA expression pattern · 19
Cripto → blastocyst, condyle, duodenum, embryo, embryonic organizer, epiblast, gastrula, gonad, islet of Langerhans, lateral plate mesoderm, mesoderm, morula, muscle tissue, olfactory zone of nasal mucosa, prefrontal cortex, rectum, right adrenal cortex, superior frontal gyrus, urinary bladder
Gene ontology · 13
Cripto → activin receptor binding, anatomical structure development, anterior/posterior pattern specification, BMP signaling pathway, cell surface, determination of left/right symmetry, development of the heart, extracellular region, gastrulation, multicellular organism development, nodal binding, nodal signaling pathway, signaling receptor binding
related to Structure · 9
Cripto → C-terminal, C1-C4, C2-C6, C3-C5, CFC, EGF-like, GPI, N-terminal, NMR
related to The role in cancer · 7
Cripto → Cripto-1, EMT, Its, Recently, TGF-B/Smad, The, The Wnt
related to Expression during embryonic development · 6
Cripto → Cripto's, For, High, It, Other, Though
related to Function · 6
Cripto → EGF-CFC, Glycosylation, GPI, In, Nodal, Particularly
related to Clinical significance · 4
Cripto → CFC1B, EGFR, Expression, Furthermore
Band · 2
Cripto → 1|1 B, 2q21.1
Chr. · 2
Cripto → Chromosome 1 (mouse), Chromosome 2 (human)

Important terminology Word statistics

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Important terminology

protein signaling gene bp pathway cryptic human development nodal chr family band embryonic cfc1b cell receptor expression chromosome cancer 1b

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
CriptoAliasesCFC1B, entrez:653275, cripto, FRL-1, cryptic family 1B1.00infobox
CriptoBand2q21.11.00infobox
CriptoBand1|1 B1.00infobox
CriptoBgeegonad1.00infobox
CriptoBgeeislet of Langerhans1.00infobox
CriptoBgeeprefrontal cortex1.00infobox
CriptoBgeerectum1.00infobox
CriptoBgeeright adrenal cortex1.00infobox
CriptoBgeeolfactory zone of nasal mucosa1.00infobox
CriptoBgeemuscle tissue1.00infobox
CriptoBgeeduodenum1.00infobox
CriptoBgeesuperior frontal gyrus1.00infobox
CriptoBgeeurinary bladder1.00infobox
CriptoBgeeembryo1.00infobox
CriptoBgeemesoderm1.00infobox
CriptoBgeegastrula1.00infobox
CriptoBgeemorula1.00infobox
CriptoBgeeblastocyst1.00infobox
CriptoBgeeembryonic organizer1.00infobox
CriptoBgeelateral plate mesoderm1.00infobox
CriptoBgeeepiblast1.00infobox
CriptoBgeecondyle1.00infobox
CriptoBioGPSn/a1.00infobox
CriptoChr.Chromosome 2 (human)1.00infobox
CriptoChr.Chromosome 1 (mouse)1.00infobox
CriptoDatabasesNCBI: entry; OMA: entry1.00infobox
CriptoEnd130,528,604 bp1.00infobox
CriptoEnd34,583,394 bp1.00infobox
CriptoEnsemblENSG000001520931.00infobox
CriptoEntrez6532751.00infobox

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