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Creatinase: Products, Organisms and discovery & Structure

In enzymology, creatinase (EC 3.5.3.3), also known as creatine amidinohydrolase, is classified as a hydrolase enzyme, acting on carbon-nitrogen bonds in linear amidines. Specifically, this enzyme breaks the amidino C-N bond in creatine, producing sarcosine and urea. Creatinase activity has been described in several bacteria species, most notably…

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Creatinase topic overview

The analysis highlights Products, Organisms and discovery and Structure as prominent areas in the source structure around Creatinase.

Related topics
36
Source areas
5
Connected nodes
41
Extracted relationships
54
Concept neighborhoods
18
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Organisms and discovery · 10 topics
Overview · 10 topics
Structure · 9 topics
Reaction pathway · 6 topics
Importance in metabolism · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
37340-58-2
EC no.
3.5.3.3
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Organisms and discovery

Structure

Reaction pathway

Importance in metabolism

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Creatinase connects Entity context

The extracted context around Creatinase shows recurring relationship patterns in the source. For example, Creatinase → Alcaligenes, AraC/GAT-R, Arthrobacter, Bacillus, CahR, Clostridium, Escherichia, Expression, Flavobacterium, Girard, In, It, Lacombe, Micrococcus, Paracoccus, Pseudomonas, Roche, This Another extracted example is Creatinase → CH, CH2CO2H, CH3, CH3N, CN, CO, H2N, H2O, HN, NH, NH2. Use these groups to spot repeated connection types before inspecting the individual relationships.

Creatinase

Top relations

related to Organisms and discovery · 18
Creatinase → Alcaligenes, AraC/GAT-R, Arthrobacter, Bacillus, CahR, Clostridium, Escherichia, Expression, Flavobacterium, Girard, In, It, Lacombe, Micrococcus, Paracoccus, Pseudomonas, Roche, This
related to Reaction pathway · 11
Creatinase → CH, CH2CO2H, CH3, CH3N, CN, CO, H2N, H2O, HN, NH, NH2
related to Importance in metabolism · 7
Creatinase → ADP, Animal, ATP, For, In, The, To
related to Structure · 3
Creatinase → Da, Each, The
related to Domains · 2
Creatinase → C-terminal, N-terminal
BRENDA · 1
Creatinase → enzyme data
CAS no. · 1
Creatinase → 37340-58-2
EC no. · 1
Creatinase → 3.5.3.3
ExPASy · 1
Creatinase → NiceZyme view
Gene Ontology · 1
Creatinase → AmiGO / QuickGO

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

enzyme creatine described ion domains bonds amidino pseudomonas c-n bond gene nitrogen carbon two putida monomer product metabolism structures sarcosine

Creatinase relationships Subject–Predicate–Object triples

TTTA extracted 54 structured relationships around Creatinase. Examples in this analysis include Creatinase → BRENDA → enzyme data and Creatinase → CAS no. → 37340-58-2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
CreatinaseBRENDAenzyme data1.00infobox
CreatinaseCAS no.37340-58-21.00infobox
CreatinaseEC no.3.5.3.31.00infobox
CreatinaseExPASyNiceZyme view1.00infobox
CreatinaseGene OntologyAmiGO / QuickGO1.00infobox
CreatinaseKEGGenzyme entry1.00infobox
CreatinaseMetaCycmetabolic pathway1.00infobox
CreatinaseNCBIproteins1.00infobox
CreatinasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
CreatinasePMCarticles1.00infobox
CreatinasePubMedarticles1.00infobox
CreatinaseRheareactions1.00infobox
CreatinaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Creatinase bring nearby vocabulary together. In this analysis, examples include Creatine, Enzyme and Nitrogen. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Creatinase
    • Creatine
    • Enzyme
    • Nitrogen
    • Bacteria
    • Metabolism
    • Pathway
    • Amino-acid
    • C-terminal
    • Carbon
    • Domain
    • Pseudomonas
    • Putida
  • creatinase
    • Creatine
    • Enzyme
    • Nitrogen
    • Bacteria
    • Metabolism
    • Pathway
    • Amino-acid
    • C-terminal
    • Carbon
    • Domain
    • Pseudomonas
    • Putida
  • enzyme
    • Described
    • Structures
    • Activity
    • Metabolism
    • Pathway
    • Pseudomonas
    • Putida
    • Domains
    • Structure
    • Bacteria
    • Sarcosine
    • Species
  • creatine
    • Enzyme
    • Nitrogen
    • Bacteria
    • Carbon
    • Putida
    • Amidino
    • Gene
    • Described
    • Activity
    • Breaks
    • Metabolism
    • Sarcosine
  • hydrogen bonds
    • Hydrogen
    • Ion
    • Monomer
    • Residues
    • Subunit
    • Amino-acid
    • C-terminal
    • Creatinase
    • Domain
    • Two
    • Creatine
    • Amidino
  • disulfide bonds
    • Hydrogen
    • Ion
    • Amino-acid
    • C-terminal
    • Creatinase
    • Domain
    • Monomer
    • Residues
    • Subunit
    • Creatine
    • Amidino
    • Two
  • carbon
    • Nitrogen
    • Metabolism
    • Species
    • Group
    • Product
    • Pseudomonas
    • Putida
    • Creatinase
    • Creatine
    • Described
    • Ion
    • Enzyme
  • active site
    • Site
    • Sarcosine
    • C-terminal
    • Domain
    • Group
    • Structures
    • Two
    • Described
    • Domains
    • Ion
    • Enzyme

Connections between topic areas Semantic bridges

For Creatinase, one of the stronger structural bridges in this analysis connects Creatinase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CreatinaseOverview · splits 31 ⟂ 11
CreatinaseOrganisms and discovery · splits 31 ⟂ 11
CreatinaseStructure · splits 32 ⟂ 10
CreatinaseReaction pathway · splits 35 ⟂ 7

Map overview Semantic statistics

Creatinase

Nodes42
Edges41
Triples54
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around Creatinase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Organisms and discovery & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Creatinase · EN edition · Analysis: TopicsToTalkAbout

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