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Committed step

In biochemistry, the committed step (also known as the first committed step) is an effectively irreversible, enzyme-catalyzed reaction that occurs at a branch point during the biosynthesis of some molecules. As the name implies, after this step, the molecules are "committed" to the pathway and will ultimately end up in the pathway's final product. The…

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Examples of enzymes that catalyze the first committed steps of metabolic pathways

Phosphofructokinase 1GlycolysisLipid A8-amino-7-oxononanoate synthaseBiotin
21 related topics

Regulation

Feedback inhibitionActivationIntermediates
3 related topics

Other uses

MetazoanFertilization
2 related topics

Overview

BiochemistryIrreversibleEnzymeCatalyzedBranch point
11 related topics

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Overview

Regulation

Examples of enzymes that catalyze the first committed steps of metabolic pathways

Other uses

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Committed step

Nodes42
Edges41
Triples22
Avg. degree1.95
Density0.047619
Components1

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Committed step

Top relations

related to Examples of enzymes that catalyze the first committed steps of metabolic pathways · 15
Committed step → Acetyl-CoA, Aspartate, Citrate, Citric Acid Cycle, CoA, D-arabinose-heptulsonate, G6P, Glucose-6-phosphate, LpxC, MurA, NADPH, Phenylalanine, Phosphofructokinase, Tryptophan, Tyrosine
related to Regulation · 3
Committed step → Metabolic, Often, Such
related to Other uses · 2
Committed step → For, The

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Important terminology

committed step first catalyzes pathway biosynthesis regulation also molecules metabolic irreversible synthase control steps pathways glycolysis acetyl-coa biochemistry processes feedback

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
feedback inhibitioninstance ofthe first committed step is regulated by processes0.80text
activationinstance ofthe first committed step is regulated by processes0.80text
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysPhosphofructokinase0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysLpxC0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysMurA0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysAspartate0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysD-arabinose-heptulsonate0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysTyrosine0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysTryptophan0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysPhenylalanine0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysCitrate0.60section
Committed steprelated to Examples of enzymes that catalyze the first committed steps of metabolic pathwaysCoA0.60section

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