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Cefiderocol: History & Applications

Cefiderocol, sold under the brand name Fetroja (by Shionogi) among others, is an antibiotic used to treat complicated urinary tract infections when no other options are available. It is indicated for the treatment of multi-drug-resistant Gram-negative bacteria including Pseudomonas aeruginosa. It is given by injection into a vein.

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Cefiderocol topic overview

The analysis highlights History and Applications as prominent areas in the source structure around Cefiderocol.

Related topics
42
Source areas
6
Connected nodes
48
Extracted relationships
85
Concept neighborhoods
18
Bridge connections
48

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 11 topics
Pharmacology · 11 topics
Medical uses · 8 topics
Adverse effects · 6 topics
History · 4 topics
In vitro activity · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
J01DI04 (WHO)
CAS Number
1225208-94-5
ChEBI
CHEBI:140376
ChEMBL
ChEMBL3989974

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Adverse effects

Pharmacology

In vitro activity

History

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Cefiderocol connects Entity context

The extracted context around Cefiderocol shows recurring relationship patterns in the source. For example, Cefiderocol → APEKS-cUTI, Archived, Clinical, ClinicalTrials, Complicated Urinary Tract Infections, Drug Information Portal, Efficacy, Intravenous Cefiderocol, Medicine, National Library, NCT02321800, November, S-649266, Safety, Study, Versus Imipenem/Cilastatin Another extracted example is Cefiderocol → Co, Drug Administration, Europe, FDA, Food, Gram-negative, In November, Mexico, Of, Qualified Infectious Disease Product, Shionogi, The, United States. Use these groups to spot repeated connection types before inspecting the individual relationships.

Cefiderocol

Top relations

related to External links · 16
Cefiderocol → APEKS-cUTI, Archived, Clinical, ClinicalTrials, Complicated Urinary Tract Infections, Drug Information Portal, Efficacy, Intravenous Cefiderocol, Medicine, National Library, NCT02321800, November, S-649266, Safety, Study, Versus Imipenem/Cilastatin
related to history · 13
Cefiderocol → Co, Drug Administration, Europe, FDA, Food, Gram-negative, In November, Mexico, Of, Qualified Infectious Disease Product, Shionogi, The, United States
related to Pharmacology · 9
Cefiderocol → C-3, Drug Administration, FDA, Food, It, Its, Once, PBPs, This
related to Medical uses · 8
Cefiderocol → Enterobacter, Escherichia, Gram-negative, In, Klebsiella, Proteus, Pseudomonas, United States
related to In vitro activity · 6
Cefiderocol → According, Antimicrobial Susceptibility Testing, European Committee, Mueller-Hinton, To, Trojan
has effect · 4
Cefiderocol → An, Gram-negative, Hence, The
Legal status · 3
Cefiderocol → EU: Rx-only, In general: ℞ (Prescription only), US: ℞-only
KEGG · 2
Cefiderocol → D11013, D11302
License data · 2
Cefiderocol → EU EMA: by INN, US DailyMed: Cefiderocol_sulfate_tosylate
3D model (JSmol) · 1
Cefiderocol → Interactive image

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

infections treatment gram-negative drug complicated urinary tract bacteria 2020 participants including caused antibiotic options european infusion fetroja iron trial indicated

Cefiderocol relationships Subject–Predicate–Object triples

TTTA extracted 85 structured relationships around Cefiderocol. Examples in this analysis include Cefiderocol → 3D model (JSmol) → Interactive image and Cefiderocol → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Cefiderocol3D model (JSmol)Interactive image1.00infobox
CefiderocolAHFS/Drugs.comMonograph1.00infobox
CefiderocolATC codeJ01DI04 (WHO)1.00infobox
CefiderocolCAS Number1225208-94-51.00infobox
CefiderocolChEBICHEBI:1403761.00infobox
CefiderocolChEMBLChEMBL39899741.00infobox
CefiderocolChemSpider520849021.00infobox
CefiderocolCompTox Dashboard (EPA)DTXSID4010980521.00infobox
CefiderocolDrug classSiderophore cephalosporins1.00infobox
CefiderocolDrugBankDB148791.00infobox
CefiderocolElimination half-life2.8 hours1.00infobox
CefiderocolExcretionmainly kidney (60–70% unchanged)1.00infobox
CefiderocolFormulaC30H34ClN7O10S21.00infobox
CefiderocolKEGGD110131.00infobox
CefiderocolKEGGD113021.00infobox
CefiderocolLegal statusUS: ℞-only1.00infobox
CefiderocolLegal statusEU: Rx-only1.00infobox
CefiderocolLegal statusIn general: ℞ (Prescription only)1.00infobox
CefiderocolLicense dataEU EMA: by INN1.00infobox
CefiderocolLicense dataUS DailyMed: Cefiderocol_sulfate_tosylate1.00infobox
CefiderocolMedlinePlusa6200081.00infobox
CefiderocolMolar mass752.21 g·mol−11.00infobox
CefiderocolOther namesRSC-6492661.00infobox
CefiderocolProtein binding56–58%1.00infobox
CefiderocolPubChem CID778439661.00infobox
CefiderocolRoutes of administrationIntravenous infusion1.00infobox
CefiderocolTrade namesFetroja, Fetcroja1.00infobox
CefiderocolUNIISZ34OMG6E81.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Cefiderocol bring nearby vocabulary together. In this analysis, examples include Infections, Complicated and Tract. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Cefiderocol
    • Infections
    • Complicated
    • Tract
    • Urinary
    • Treatment
    • Gram-negative
    • Caused
    • Options
    • Bacteria
    • Including
    • Adults
    • Alternative
  • cefiderocol
    • Infections
    • Complicated
    • Tract
    • Urinary
    • Treatment
    • Gram-negative
    • Caused
    • Options
    • Bacteria
    • Including
    • Adults
    • Alternative
  • urinary tract infections
    • Tract
    • Urinary
    • Infections
    • Options
    • Adults
    • Alternative
    • Limited
    • Gram-negative
    • Caused
    • Including
    • Treatment
    • Participants
  • gram-negative
    • Treatment
    • Caused
    • Adults
    • Indicated
    • Limited
    • Options
    • Bacteria
    • Including
    • Pseudomonas
    • Aeruginosa
    • Alternative
    • Antibiotics
  • bacteria
    • Indicated
    • Treatment
    • Gram-negative
    • Pseudomonas
    • Aeruginosa
    • Antibiotics
    • Caused
    • Cefiderocol
    • Fetroja
    • Used
    • Adults
    • Alternative
  • multidrug-resistant gram-negative bacterial
    • Treatment
    • Caused
    • Adults
    • Indicated
    • Limited
    • Options
    • Bacteria
    • Including
    • Pseudomonas
    • Aeruginosa
    • Alternative
    • Antibiotics
  • bloodstream infections
    • Tract
    • Urinary
    • Options
    • Gram-negative
    • Adults
    • Limited
    • Treatment
    • Alternative
    • Clinical
    • Trial
    • Caused
    • Including
  • food and drug administration
    • Fda
    • Infusion
    • Administration
    • Drug
    • Including
    • Treatment
    • Gram-negative
    • Tract
    • Urinary
    • Fetroja
    • Adults
    • Alternative

Connections between topic areas Semantic bridges

For Cefiderocol, one of the stronger structural bridges in this analysis connects Cefiderocol with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Cefiderocol — Overview · splits 37 ⟂ 12
Cefiderocol — Pharmacology · splits 37 ⟂ 12
Cefiderocol — Medical uses · splits 40 ⟂ 9
Cefiderocol — Adverse effects · splits 42 ⟂ 7
Cefiderocol — History · splits 44 ⟂ 5
Cefiderocol — In vitro activity · splits 46 ⟂ 3

Map overview Semantic statistics

Cefiderocol

Nodes49
Edges48
Triples85
Avg. degree1.96
Density0.040816
Components1

Source & methodology

TTTA analyzes the structure around Cefiderocol to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Cefiderocol · EN edition · Analysis: TopicsToTalkAbout

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