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BMPR2

Bone morphogenetic protein receptor type II or BMPR2 is a serine/threonine receptor kinase encoded by the BMPR2 gene. It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling. BMPs are involved in a host of cellular functions including osteogenesis, cell growth and cell…

Oocyte development, Function & Clinical significance

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2.7.11.30
Aliases
BMPR2, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2HLQ, 3G2F
Band
2q33.1-q33.2 · 1|1 C2
Bgee
visceral pleura · lower lobe of lung · tendon of biceps brachii · urethra · lateral nuclear group of thalamus
BioGPS
n/a

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Overview

Function

Oocyte development

Clinical significance

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Map overview Semantic statistics

BMPR2

Nodes39
Edges38
Triples200
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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BMPR2

Top relations

Gene ontology · 94
BMPR2 → activin receptor activity, type II, activin receptor signaling pathway, anterior/posterior pattern specification, aortic valve development, apical plasma membrane, artery development, ATP binding, atrial septum morphogenesis, atrioventricular valve morphogenesis, basal plasma membrane, blood vessel remodeling, BMP binding, BMP receptor activity, BMP signaling pathway, brain development, cardiac muscle tissue development, caveola, cell surface, cellular response to BMP stimulus, cellular response to starvation
Bgee · 20
BMPR2 → carotid body, ciliary body, cumulus cell, epithelium of lens, iris, lateral nuclear group of thalamus, lower lobe of lung, molar, parietal pleura, pineal gland, retinal pigment epithelium, right lung, right lung lobe, skin of hip, skin of thigh, substantia nigra, tail of epididymis, tendon of biceps brachii, urethra, visceral pleura
RNA expression pattern · 20
BMPR2 → carotid body, ciliary body, cumulus cell, epithelium of lens, iris, lateral nuclear group of thalamus, lower lobe of lung, molar, parietal pleura, pineal gland, retinal pigment epithelium, right lung, right lung lobe, skin of hip, skin of thigh, substantia nigra, tail of epididymis, tendon of biceps brachii, urethra, visceral pleura
related to Function · 19
BMPR2 → Binding, BMP, BMP-2, BMP-4, BMP-7, BMPs, II, II TGF, In, In TGF, On, Once, SMAD, TGF-β1, TGFβ, The, They, Type II, Unlike
related to Oocyte development · 12
BMPR2 → BMP15, BMPR1B, BMPR2-mediated, Experimental, FSH, GDF9, However, It, KGN, TGFβR1, There, These
related to Clinical significance · 5
BMPR2 → An, At, It, The, When
related to External links · 4
BMPR2 → Heritable Pulmonary Arterial HypertensionHuman, Heritable Pulmonary Arterial HypertensionOMIM, NCBI/NIH/UW, UCSC Genome Browser
Band · 2
BMPR2 → 1|1 C2, 2q33.1-q33.2
Chr. · 2
BMPR2 → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
BMPR2 → 202,567,751 bp, 59,918,173 bp

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Important terminology

receptor type ii gene human bone bp pulmonary signaling protein binding morphogenetic bmp chr band arterial growth ligand chromosome beta

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BMPR22.7.11.301.00infobox
BMPR2AliasesBMPR2, BMPR-II, BMPR3, BMR2, BRK-3, POVD1, PPH1, T-ALK, bone morphogenetic protein receptor type 21.00infobox
BMPR2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2HLQ, 3G2F1.00infobox
BMPR2Band2q33.1-q33.21.00infobox
BMPR2Band1|1 C21.00infobox
BMPR2Bgeevisceral pleura1.00infobox
BMPR2Bgeelower lobe of lung1.00infobox
BMPR2Bgeetendon of biceps brachii1.00infobox
BMPR2Bgeeurethra1.00infobox
BMPR2Bgeelateral nuclear group of thalamus1.00infobox
BMPR2Bgeeparietal pleura1.00infobox
BMPR2Bgeeright lung1.00infobox
BMPR2Bgeeskin of thigh1.00infobox
BMPR2Bgeeskin of hip1.00infobox
BMPR2Bgeetail of epididymis1.00infobox
BMPR2Bgeecumulus cell1.00infobox
BMPR2Bgeeciliary body1.00infobox
BMPR2Bgeeiris1.00infobox
BMPR2Bgeecarotid body1.00infobox
BMPR2Bgeeright lung lobe1.00infobox
BMPR2Bgeesubstantia nigra1.00infobox
BMPR2Bgeemolar1.00infobox
BMPR2Bgeeretinal pigment epithelium1.00infobox
BMPR2Bgeepineal gland1.00infobox
BMPR2Bgeeepithelium of lens1.00infobox
BMPR2BioGPSn/a1.00infobox
BMPR2Chr.Chromosome 2 (human)1.00infobox
BMPR2Chr.Chromosome 1 (mouse)1.00infobox
BMPR2DatabasesNCBI: entry; OMA: entry1.00infobox
BMPR2End202,567,751 bp1.00infobox

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