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Bile acid: Standards, Clinical significance & Structure and synthesis

Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver in peroxisomes. Bile acids are conjugated with taurine or glycine residues to give anions called bile salts.

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Bile acid topic overview

The analysis highlights Standards, Clinical significance and Structure and synthesis as prominent areas in the source structure around Bile acid.

Related topics
97
Source areas
7
Connected nodes
104
Extracted relationships
64
Related term clusters
35
Bridge connections
104

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 21 topics
Overview · 18 topics
Structure and synthesis · 15 topics
Hormonal actions · 13 topics
Functions · 11 topics
Production · 10 topics
Description · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Description

Production

Functions

Structure and synthesis

Hormonal actions

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Bile acid connects Entity context

The extracted context around Bile acid shows recurring relationship patterns in the source. For example, Bile acid → Among, Anandamide, Bile, FXR, N-acyl, NAPE-PLD, Oleoylethanolamide, Palmitoylethanolamide, TGR5 Another extracted example is Bile acid → Another, Bile, Farnesoid, FXR, Many, NR1H4, TGR5. Use these groups to spot repeated connection types before inspecting the individual relationships.

Bile acid

Top relations

related to Bile acids are cofactors of membrane NAPE-PLD · 9
Bile acid → Among, Anandamide, Bile, FXR, N-acyl, NAPE-PLD, Oleoylethanolamide, Palmitoylethanolamide, TGR5
related to Hormonal actions · 7
Bile acid → Another, Bile, Farnesoid, FXR, Many, NR1H4, TGR5
related to Cholestasis · 5
Bile acid → Bile, PBC, Structural, Tests, Treatment
related to Dermatology · 5
Bile acid → Bile, Deoxycholic, FDA, Mesotherapy, Phase III
related to Gallstones · 5
Bile acid → Bile, Gallstones, Lower, Oral, Stones
related to Bile acid diarrhea · 4
Bile acid → Crohn's, Excess, IBS-D, SeHCAT
related to Lipid digestion · 4
Bile acid → Bile, Critical, Human, Synthesis
related to Primary bile acids · 4
Bile acid → Approximately, Bile, FGF15/19, P450-mediated
related to Regulation of synthesis · 4
Bile acid → Activation, FGF19, FXR, Secondly
related to Description · 3
Bile acid → Bile, GPBAR1, TGR5

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bile acids acid cholesterol liver chenodeoxycholic hydroxyl synthesis salts group cholic position deoxycholic steroid intestine may also found primary actions

Bile acid relationships Subject–Predicate–Object triples

TTTA extracted 64 structured relationships around Bile acid. Examples in this analysis include intrahepatic cholestasis of pregnancy → instance of → including types of cholestasis and primary biliary cirrhosis → instance of → which is common in cholestatic conditions. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
intrahepatic cholestasis of pregnancyinstance ofincluding types of cholestasis0.80text
portosystemic shuntinstance ofincluding types of cholestasis0.80text
and hepatic microvascular dysplasia in dogsinstance ofincluding types of cholestasis0.80text
primary biliary cirrhosisinstance ofwhich is common in cholestatic conditions0.80text
following bariatric surgery.Bile acid diarrheaExcess concentrations of bile acids in the colon are a cause of chronic diarrheainstance ofBile acid therapy may be of value to prevent stones in certain circumstances0.80text
following bariatric surgeryinstance ofBile acid therapy may be of value to prevent stones in certain circumstances0.80text
Bile acidrelated to Bile acid diarrheaExcess0.60section
Bile acidrelated to Bile acid diarrheaCrohn's0.60section
Bile acidrelated to Bile acid diarrheaIBS-D0.60section
Bile acidrelated to Bile acid diarrheaSeHCAT0.60section
Bile acidrelated to Bile acids and colon cancerBile0.60section
Bile acidrelated to Bile acids and colon cancerDeoxycholic0.60section

Related concept clusters Related term clusters

The concept neighborhoods around Bile acid bring nearby vocabulary together. In this analysis, examples include Acid, Bile and Synthesis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Bile acid
    • Acid
    • Bile
    • Synthesis
    • 3α
    • Cholesterol
    • Salts
    • Liver
    • Acids
    • Lithocholic
    • Groups
    • Chenodeoxycholic
    • Humans
  • bile acid
    • Acid
    • Bile
    • Chenodeoxycholic
    • Cholic
    • Hydroxyl
    • Deoxycholic
    • Synthesis
    • 3α
    • Cholesterol
    • Salts
    • Liver
    • Acids
  • acids
    • Bile
    • Cholesterol
    • Acid
    • Liver
    • Salts
    • Synthesis
    • Intestine
    • Biliary
    • Colon
    • Actions
    • Primary
    • Also
  • bile
    • Acid
    • Synthesis
    • Cholesterol
    • Salts
    • Liver
    • Chenodeoxycholic
    • Intestine
    • Also
    • Cholic
    • Conjugated
    • Hydroxyl
    • Biliary
  • taurocholic acid
    • Bile
    • Chenodeoxycholic
    • Cholic
    • Hydroxyl
    • Deoxycholic
    • Synthesis
    • 3α
    • Acids
    • Group
    • Lithocholic
    • Groups
    • Liver
  • glycocholic acid
    • Bile
    • Chenodeoxycholic
    • Cholic
    • Hydroxyl
    • Deoxycholic
    • Synthesis
    • 3α
    • Acids
    • Group
    • Lithocholic
    • Groups
    • Liver
  • cholic acid
    • Chenodeoxycholic
    • Bile
    • Deoxycholic
    • Humans
    • Cholic
    • Lithocholic
    • Groups
    • Hydroxyl
    • Synthesis
    • Salts
    • 3α
    • Found
  • taurochenodeoxycholic acid
    • Bile
    • Chenodeoxycholic
    • Cholic
    • Hydroxyl
    • Deoxycholic
    • Synthesis
    • 3α
    • Acids
    • Group
    • Lithocholic
    • Groups
    • Liver

Connections between topic areas Semantic bridges

For Bile acid, one of the stronger structural bridges in this analysis connects Bile acid with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Bile acid — Clinical significance · splits 83 ⟂ 22
Bile acid — Overview · splits 86 ⟂ 19
Bile acid — Structure and synthesis · splits 89 ⟂ 16
Bile acid — Hormonal actions · splits 91 ⟂ 14
Bile acid — Functions · splits 93 ⟂ 12
Bile acid — Production · splits 94 ⟂ 11
Bile acid — Description · splits 95 ⟂ 10

Map overview Semantic statistics

Bile acid

Nodes105
Edges104
Triples64
Avg. degree1.98
Density0.019048
Components1

Source & methodology

TTTA analyzes the structure around Bile acid to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Clinical significance & Structure and synthesis, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Bile acid · EN edition · Analysis: TopicsToTalkAbout

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