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FGF19: Standards, Functions & Clinical significance

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

Language: English [EN]
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FGF19 topic overview

The analysis highlights Standards, Functions and Clinical significance as prominent areas in the source structure around FGF19.

Related topics
32
Source areas
3
Connected nodes
35
Extracted relationships
94
Concept neighborhoods
20
Bridge connections
35

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Functions · 14 topics
Clinical significance · 13 topics
Overview · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
FGF19, fibroblast growth factor 19
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23
Band
11q13.3 · 7|7 F5
Bgee
gallbladder · gonad · islet of Langerhans · sural nerve · small intestine
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 7 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Functions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How FGF19 connects Entity context

The extracted context around FGF19 shows recurring relationship patterns in the source. For example, FGF19 → 1-phosphatidylinositol-3-kinase activity, development of the heart, extracellular region, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, intracellular anatomical structure, MAPK cascade, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, nervous system development, neural crest cell migration, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of JNK cascade, positive regulation of protein kinase B signaling Another extracted example is FGF19 → cerebellar cortex, cerebellar hemisphere, dorsal nucleus of lateral geniculate body, duodenum, embryo, epiblast, gallbladder, gonad, gray matter layer of cerebellum, islet of Langerhans, medial habenular nucleus, mucosa of small intestine, pretectal area, primitive streak, Purkinje cell, right hemisphere of cerebellum, small intestine, sural nerve, tail of embryo. Use these groups to spot repeated connection types before inspecting the individual relationships.

FGF19

Top relations

Gene ontology · 24
FGF19 → 1-phosphatidylinositol-3-kinase activity, development of the heart, extracellular region, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, intracellular anatomical structure, MAPK cascade, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, nervous system development, neural crest cell migration, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of JNK cascade, positive regulation of protein kinase B signaling
Bgee · 19
FGF19 → cerebellar cortex, cerebellar hemisphere, dorsal nucleus of lateral geniculate body, duodenum, embryo, epiblast, gallbladder, gonad, gray matter layer of cerebellum, islet of Langerhans, medial habenular nucleus, mucosa of small intestine, pretectal area, primitive streak, Purkinje cell, right hemisphere of cerebellum, small intestine, sural nerve, tail of embryo
RNA expression pattern · 19
FGF19 → cerebellar cortex, cerebellar hemisphere, dorsal nucleus of lateral geniculate body, duodenum, embryo, epiblast, gallbladder, gonad, gray matter layer of cerebellum, islet of Langerhans, medial habenular nucleus, mucosa of small intestine, pretectal area, primitive streak, Purkinje cell, right hemisphere of cerebellum, small intestine, sural nerve, tail of embryo
related to Clinical significance · 6
FGF19 → Crohn's, In, Patients, SeHCAT, Surgical, This
related to Role as a cancer promoter · 3
FGF19 → Amplification, Increase, Targeting FGF19
Band · 2
FGF19 → 11q13.3, 7|7 F5
Chr. · 2
FGF19 → Chromosome 11 (human), Chromosome 7 (mouse)
End · 2
FGF19 → 144,900,953 bp, 69,704,022 bp
Aliases · 1
FGF19 → FGF19, fibroblast growth factor 19
Available structures · 1
FGF19 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bile acid gene human growth factor bp chr band synthesis diarrhea fibroblast chromosome 11 protein mouse liver patients reduced functions

FGF19 relationships Subject–Predicate–Object triples

TTTA extracted 94 structured relationships around FGF19. Examples in this analysis include FGF19 → Aliases → FGF19, fibroblast growth factor 19 and FGF19 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
FGF19AliasesFGF19, fibroblast growth factor 191.00infobox
FGF19Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P231.00infobox
FGF19Band11q13.31.00infobox
FGF19Band7|7 F51.00infobox
FGF19Bgeegallbladder1.00infobox
FGF19Bgeegonad1.00infobox
FGF19Bgeeislet of Langerhans1.00infobox
FGF19Bgeesural nerve1.00infobox
FGF19Bgeesmall intestine1.00infobox
FGF19Bgeemucosa of small intestine1.00infobox
FGF19Bgeeduodenum1.00infobox
FGF19Bgeecerebellar cortex1.00infobox
FGF19Bgeecerebellar hemisphere1.00infobox
FGF19Bgeeright hemisphere of cerebellum1.00infobox
FGF19Bgeegray matter layer of cerebellum1.00infobox
FGF19Bgeedorsal nucleus of lateral geniculate body1.00infobox
FGF19BgeePurkinje cell1.00infobox
FGF19Bgeeembryo1.00infobox
FGF19Bgeeprimitive streak1.00infobox
FGF19Bgeetail of embryo1.00infobox
FGF19Bgeeepiblast1.00infobox
FGF19Bgeemedial habenular nucleus1.00infobox
FGF19Bgeepretectal area1.00infobox
FGF19BioGPSMore reference expression data1.00infobox
FGF19Chr.Chromosome 11 (human)1.00infobox
FGF19Chr.Chromosome 7 (mouse)1.00infobox
FGF19DatabasesNCBI: entry; OMA: entry1.00infobox
FGF19End69,704,022 bp1.00infobox
FGF19End144,900,953 bp1.00infobox
FGF19EnsemblENSG000001623441.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around FGF19 bring nearby vocabulary together. In this analysis, examples include Bile, Acid and Patients. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • FGF19
    • Bile
    • Acid
    • Patients
    • Response
    • Diarrhea
    • Liver
    • Gene
    • Growth
    • Human
    • Absorption
    • Cancer
    • Fibroblast
  • fgf19
    • Bile
    • Acid
    • Patients
    • Response
    • Diarrhea
    • Liver
    • Gene
    • Growth
    • Human
    • Absorption
    • Cancer
    • Fibroblast
  • bile acid
    • Acid
    • Bile
    • Fgf19
    • Synthesis
    • Response
    • Acids
    • Diarrhea
    • Absorption
    • Chronic
    • Receptor
    • Reduced
    • Shown
  • bile acid diarrhea
    • Acid
    • Bile
    • Reduced
    • Fgf19
    • Synthesis
    • Levels
    • Response
    • Acids
    • Diarrhea
    • Shown
    • Patients
    • Absorption
  • fibroblast growth factor
    • Encoded
    • Factor
    • Fibroblast
    • Growth
    • Gene
    • Location
    • Protein
    • Chromosome
    • Bp
    • Chr
    • Cancer
    • Development
  • chenodeoxycholic acid
    • Bile
    • Synthesis
    • Fgf19
    • Response
    • Diarrhea
    • Absorption
    • Chronic
    • Acids
    • Reduced
    • Shown
    • Hormone
    • Functions
  • glycochenodeoxycholic acid
    • Bile
    • Synthesis
    • Fgf19
    • Response
    • Diarrhea
    • Absorption
    • Chronic
    • Acids
    • Reduced
    • Shown
    • Hormone
    • Functions
  • obeticholic acid
    • Bile
    • Synthesis
    • Fgf19
    • Response
    • Diarrhea
    • Absorption
    • Chronic
    • Acids
    • Reduced
    • Shown
    • Hormone
    • Functions

Connections between topic areas Semantic bridges

For FGF19, one of the stronger structural bridges in this analysis connects FGF19 with Functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
FGF19Functions · splits 21 ⟂ 15
FGF19Clinical significance · splits 22 ⟂ 14
FGF19Overview · splits 30 ⟂ 6

Map overview Semantic statistics

FGF19

Nodes36
Edges35
Triples94
Avg. degree1.94
Density0.055556
Components1

Source & methodology

TTTA analyzes the structure around FGF19 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Functions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — FGF19 · EN edition · Analysis: TopicsToTalkAbout

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