FGF19

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Functions

Fibroblast growth factor Morphogenesis Heparin FGFR4 FGF15

14 related topics

Clinical significance

Chronic diarrhea Bile acid malabsorption Crohn's disease Primary bile acid diarrhea 7α-hydroxy-4-cholesten-3-one

13 related topics

Overview

Protein Gene Hormone Bile acid Bile acid diarrhea

5 related topics

Key facts & relationships

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Aliases: FGF19, fibroblast growth factor 19
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23
Band: 11q13.3 · 7|7 F5
Bgee: gallbladder · gonad · islet of Langerhans · sural nerve · small intestine
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 7 (mouse)

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Map overview Semantic statistics

Nodes36

Edges35

Triples94

Avg. degree1.94

Density0.055556

Components1

How this topic connects Entity context

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FGF19

Top relations

Gene ontology · 24

FGF19 → 1-phosphatidylinositol-3-kinase activity, development of the heart, extracellular region, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, intracellular anatomical structure, MAPK cascade, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, nervous system development, neural crest cell migration, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of JNK cascade, positive regulation of protein kinase B signaling

Bgee · 19

FGF19 → cerebellar cortex, cerebellar hemisphere, dorsal nucleus of lateral geniculate body, duodenum, embryo, epiblast, gallbladder, gonad, gray matter layer of cerebellum, islet of Langerhans, medial habenular nucleus, mucosa of small intestine, pretectal area, primitive streak, Purkinje cell, right hemisphere of cerebellum, small intestine, sural nerve, tail of embryo

RNA expression pattern · 19

related to Clinical significance · 6

FGF19 → Crohn's, In, Patients, SeHCAT, Surgical, This

related to Role as a cancer promoter · 3

FGF19 → Amplification, Increase, Targeting FGF19

Band · 2

FGF19 → 11q13.3, 7|7 F5

Chr. · 2

FGF19 → Chromosome 11 (human), Chromosome 7 (mouse)

End · 2

FGF19 → 144,900,953 bp, 69,704,022 bp

Aliases · 1

FGF19 → FGF19, fibroblast growth factor 19

Available structures · 1

FGF19 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23

Important terminology Word statistics

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Important terminology

bile acid gene human growth factor bp chr band synthesis diarrhea fibroblast chromosome 11 protein mouse liver patients reduced functions

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
FGF19	Aliases	FGF19, fibroblast growth factor 19	1.00	infobox
FGF19	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23	1.00	infobox
FGF19	Band	11q13.3	1.00	infobox
FGF19	Band	7\|7 F5	1.00	infobox
FGF19	Bgee	gallbladder	1.00	infobox
FGF19	Bgee	gonad	1.00	infobox
FGF19	Bgee	islet of Langerhans	1.00	infobox
FGF19	Bgee	sural nerve	1.00	infobox
FGF19	Bgee	small intestine	1.00	infobox
FGF19	Bgee	mucosa of small intestine	1.00	infobox
FGF19	Bgee	duodenum	1.00	infobox
FGF19	Bgee	cerebellar cortex	1.00	infobox
FGF19	Bgee	cerebellar hemisphere	1.00	infobox
FGF19	Bgee	right hemisphere of cerebellum	1.00	infobox
FGF19	Bgee	gray matter layer of cerebellum	1.00	infobox
FGF19	Bgee	dorsal nucleus of lateral geniculate body	1.00	infobox
FGF19	Bgee	Purkinje cell	1.00	infobox
FGF19	Bgee	embryo	1.00	infobox
FGF19	Bgee	primitive streak	1.00	infobox
FGF19	Bgee	tail of embryo	1.00	infobox
FGF19	Bgee	epiblast	1.00	infobox
FGF19	Bgee	medial habenular nucleus	1.00	infobox
FGF19	Bgee	pretectal area	1.00	infobox
FGF19	BioGPS	More reference expression data	1.00	infobox
FGF19	Chr.	Chromosome 11 (human)	1.00	infobox
FGF19	Chr.	Chromosome 7 (mouse)	1.00	infobox
FGF19	Databases	NCBI: entry; OMA: entry	1.00	infobox
FGF19	End	69,704,022 bp	1.00	infobox
FGF19	End	144,900,953 bp	1.00	infobox
FGF19	Ensembl	ENSG00000162344	1.00	infobox

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