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Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.
The analysis highlights Standards, Functions and Clinical significance as prominent areas in the source structure around FGF19.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around FGF19 shows recurring relationship patterns in the source. For example, FGF19 → 1-phosphatidylinositol-3-kinase activity, development of the heart, extracellular region, fibroblast growth factor receptor binding, fibroblast growth factor receptor signaling pathway, growth factor activity, intracellular anatomical structure, MAPK cascade, negative regulation of bile acid biosynthetic process, negative regulation of gene expression, nervous system development, neural crest cell migration, phosphatidylinositol phosphate biosynthetic process, phosphatidylinositol-3-phosphate biosynthetic process, phosphatidylinositol-4,5-bisphosphate 3-kinase activity, positive regulation of cell population proliferation, positive regulation of ERK1 and ERK2 cascade, positive regulation of glucose import, positive regulation of JNK cascade, positive regulation of protein kinase B signaling Another extracted example is FGF19 → cerebellar cortex, cerebellar hemisphere, dorsal nucleus of lateral geniculate body, duodenum, embryo, epiblast, gallbladder, gonad, gray matter layer of cerebellum, islet of Langerhans, medial habenular nucleus, mucosa of small intestine, pretectal area, primitive streak, Purkinje cell, right hemisphere of cerebellum, small intestine, sural nerve, tail of embryo. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bile acid gene human growth factor bp chr band synthesis diarrhea fibroblast chromosome 11 protein mouse liver patients reduced functions
TTTA extracted 94 structured relationships around FGF19. Examples in this analysis include FGF19 → Aliases → FGF19, fibroblast growth factor 19 and FGF19 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| FGF19 | Aliases | FGF19, fibroblast growth factor 19 | 1.00 | infobox |
| FGF19 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PWA, 2P23 | 1.00 | infobox |
| FGF19 | Band | 11q13.3 | 1.00 | infobox |
| FGF19 | Band | 7|7 F5 | 1.00 | infobox |
| FGF19 | Bgee | gallbladder | 1.00 | infobox |
| FGF19 | Bgee | gonad | 1.00 | infobox |
| FGF19 | Bgee | islet of Langerhans | 1.00 | infobox |
| FGF19 | Bgee | sural nerve | 1.00 | infobox |
| FGF19 | Bgee | small intestine | 1.00 | infobox |
| FGF19 | Bgee | mucosa of small intestine | 1.00 | infobox |
| FGF19 | Bgee | duodenum | 1.00 | infobox |
| FGF19 | Bgee | cerebellar cortex | 1.00 | infobox |
| FGF19 | Bgee | cerebellar hemisphere | 1.00 | infobox |
| FGF19 | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| FGF19 | Bgee | gray matter layer of cerebellum | 1.00 | infobox |
| FGF19 | Bgee | dorsal nucleus of lateral geniculate body | 1.00 | infobox |
| FGF19 | Bgee | Purkinje cell | 1.00 | infobox |
| FGF19 | Bgee | embryo | 1.00 | infobox |
| FGF19 | Bgee | primitive streak | 1.00 | infobox |
| FGF19 | Bgee | tail of embryo | 1.00 | infobox |
| FGF19 | Bgee | epiblast | 1.00 | infobox |
| FGF19 | Bgee | medial habenular nucleus | 1.00 | infobox |
| FGF19 | Bgee | pretectal area | 1.00 | infobox |
| FGF19 | BioGPS | More reference expression data | 1.00 | infobox |
| FGF19 | Chr. | Chromosome 11 (human) | 1.00 | infobox |
| FGF19 | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| FGF19 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| FGF19 | End | 69,704,022 bp | 1.00 | infobox |
| FGF19 | End | 144,900,953 bp | 1.00 | infobox |
| FGF19 | Ensembl | ENSG00000162344 | 1.00 | infobox |
The concept neighborhoods around FGF19 bring nearby vocabulary together. In this analysis, examples include Bile, Acid and Patients. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For FGF19, one of the stronger structural bridges in this analysis connects FGF19 with Functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around FGF19 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Functions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — FGF19 · EN edition · Analysis: TopicsToTalkAbout