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ATP7A

ATP7A, also known as Menkes' protein (MNK), is a copper-transporting P-type ATPase which uses the energy arising from ATP hydrolysis to transport Cu(I) across cell membranes. The ATP7A protein is a transmembrane protein and is expressed in the intestine and all tissues except liver. In the intestine, ATP7A regulates Cu(I) absorption in the human body by…

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7.2.2.8
Aliases
ATP7A, DSMAX, MK, MNK, SMAX3, ATPase copper transporting alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AW0, 1KVI, 1KVJ, 1Q8L, 1S6O, 1S6U, 1Y3J, 1Y3K, 1YJR, 1YJT, 1YJU, 1YJV, 2G9O, 2GA7, 2K1R, 2KIJ, 2KMV, 2KMX,…
Band
Xq21.1 · X D|X 47.36 cM
Bgee
buccal mucosa cell · trabecular bone · skin of thigh · germinal epithelium · corpus epididymis
BioGPS
n/a

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Overview

Gene

Structure

Conformational change

Transport mechanism

Function

Interactions

Clinical significance

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Map overview Semantic statistics

ATP7A

Nodes37
Edges36
Triples236
Avg. degree1.95
Density0.054054
Components1

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ATP7A

Top relations

Gene ontology · 103
ATP7A → antimicrobial humoral response, apical plasma membrane, ATP binding, ATPase-coupled cation transmembrane transporter activity, basolateral plasma membrane, blood vessel development, blood vessel remodeling, brush border membrane, cartilage development, catecholamine metabolic process, cation transport, cell leading edge, cellular copper ion homeostasis, cellular response to amino acid stimulus, cellular response to antibiotic, cellular response to cadmium ion, cellular response to cobalt ion, cellular response to copper ion, cellular response to hypoxia, cellular response to iron ion
Bgee · 20
ATP7A → Achilles tendon, buccal mucosa cell, choroid plexus of fourth ventricle, corpus epididymis, efferent ductule, Epithelium of choroid plexus, external carotid artery, germinal epithelium, internal carotid artery, iris, left lung lobe, parietal pleura, retinal pigment epithelium, Rostral migratory stream, skin of hip, skin of thigh, tibia, trabecular bone, vas deferens, visceral pleura
RNA expression pattern · 20
ATP7A → Achilles tendon, buccal mucosa cell, choroid plexus of fourth ventricle, corpus epididymis, efferent ductule, Epithelium of choroid plexus, external carotid artery, germinal epithelium, internal carotid artery, iris, left lung lobe, parietal pleura, retinal pigment epithelium, Rostral migratory stream, skin of hip, skin of thigh, tibia, trabecular bone, vas deferens, visceral pleura
related to Clinical significance · 14
ATP7A → American College, As, Copper, Cu, DNA, Genomics, Golgi, Many, Medical Genetics, Menkes, OHS, Other, Researchers, The
related to External links · 11
ATP7A → ATP7A-Related Copper Transport Disorders, ATP7A-Related Copper Transport DisordersGeneCardHuman, ATP7A-Related Distal Motor NeuropathyOMIM, GeneReviews/NCBI/NIH/UW, Includes, Medicine Medical Subject Headings, Menkes Disease, MeSH, National Library, Occipital Horn Syndrome, UCSC Genome Browser
related to Transport mechanism · 11
ATP7A → ATP, ATP-binding, Cu, DKTG, E1, E2, In, P-type ATPases, The, Then ATP7A, Within
related to Interactions · 9
ATP7A → Antioxidant, ATOX1, Cu, GLRX, Glutaredoxin-1, GMTCXXC, Golgi-network, GRX1, It
related to Function · 8
ATP7A → After Cu, Cu, Golgi, Here, If Cu, In, The, This
related to Structure · 8
ATP7A → An ATP-binding, ATP7B, C-termini, Cu, Eight, GMTCXXC, It, N-terminal
related to Gene · 5
ATP7A → At, Mutations/additions/deletions, The, The ATP7A, Xq21

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Important terminology

cu protein gene copper human transport transmembrane cell mutations function bp binding band tissues membrane chr motif disease chromosome also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ATP7A7.2.2.81.00infobox
ATP7AAliasesATP7A, DSMAX, MK, MNK, SMAX3, ATPase copper transporting alpha1.00infobox
ATP7AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AW0, 1KVI, 1KVJ, 1Q8L, 1S6O, 1S6U, 1Y3J, 1Y3K, 1YJR, 1YJT, 1YJU, 1YJV, 2G9O, 2GA7, 2K1R, 2KIJ, 2KMV, 2KMX,…1.00infobox
ATP7ABandXq21.11.00infobox
ATP7ABandX D|X 47.36 cM1.00infobox
ATP7ABgeebuccal mucosa cell1.00infobox
ATP7ABgeetrabecular bone1.00infobox
ATP7ABgeeskin of thigh1.00infobox
ATP7ABgeegerminal epithelium1.00infobox
ATP7ABgeecorpus epididymis1.00infobox
ATP7ABgeetibia1.00infobox
ATP7ABgeeAchilles tendon1.00infobox
ATP7ABgeeparietal pleura1.00infobox
ATP7ABgeevisceral pleura1.00infobox
ATP7ABgeeskin of hip1.00infobox
ATP7ABgeeEpithelium of choroid plexus1.00infobox
ATP7ABgeeRostral migratory stream1.00infobox
ATP7ABgeeinternal carotid artery1.00infobox
ATP7ABgeechoroid plexus of fourth ventricle1.00infobox
ATP7ABgeeexternal carotid artery1.00infobox
ATP7ABgeeretinal pigment epithelium1.00infobox
ATP7ABgeevas deferens1.00infobox
ATP7ABgeeleft lung lobe1.00infobox
ATP7ABgeeefferent ductule1.00infobox
ATP7ABgeeiris1.00infobox
ATP7ABioGPSn/a1.00infobox
ATP7AChr.X chromosome (human)1.00infobox
ATP7AChr.X chromosome (mouse)1.00infobox
ATP7ADatabasesNCBI: entry; OMA: entry1.00infobox
ATP7AEnd78,050,395 bp1.00infobox

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