ATP7A

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ATP7A topic overview

The analysis highlights Structure, Clinical significance and Interactions as prominent areas in the source structure around ATP7A.

Related topics: 28
Source areas: 8
Connected nodes: 36
Extracted relationships: 236
Concept neighborhoods: 17
Bridge connections: 36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 8 topics

Structure · 6 topics

Clinical significance · 4 topics

Interactions · 3 topics

Conformational change · 2 topics

Function · 2 topics

Gene · 2 topics

Transport mechanism · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

7.2.2.8: ↗
Aliases: ATP7A, DSMAX, MK, MNK, SMAX3, ATPase copper transporting alpha
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AW0, 1KVI, 1KVJ, 1Q8L, 1S6O, 1S6U, 1Y3J, 1Y3K, 1YJR, 1YJT, 1YJU, 1YJV, 2G9O, 2GA7, 2K1R, 2KIJ, 2KMV, 2KMX,…
Band: Xq21.1 · X D|X 47.36 cM
Bgee: buccal mucosa cell · trabecular bone · skin of thigh · germinal epithelium · corpus epididymis
BioGPS: n/a

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

P-type ATPase
ATP hydrolysis
Transmembrane protein
Golgi apparatus
Peptidyl-α-monooxygenase Peptidylglycine monooxygenase
Tyrosinase
Lysyl oxidase
Menkes disease

Gene

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ATP7A connects Entity context

The extracted context around ATP7A shows recurring relationship patterns in the source. For example, ATP7A → antimicrobial humoral response, apical plasma membrane, ATP binding, ATPase-coupled cation transmembrane transporter activity, basolateral plasma membrane, blood vessel development, blood vessel remodeling, brush border membrane, cartilage development, catecholamine metabolic process, cation transport, cell leading edge, cellular copper ion homeostasis, cellular response to amino acid stimulus, cellular response to antibiotic, cellular response to cadmium ion, cellular response to cobalt ion, cellular response to copper ion, cellular response to hypoxia, cellular response to iron ion Another extracted example is ATP7A → Achilles tendon, buccal mucosa cell, choroid plexus of fourth ventricle, corpus epididymis, efferent ductule, Epithelium of choroid plexus, external carotid artery, germinal epithelium, internal carotid artery, iris, left lung lobe, parietal pleura, retinal pigment epithelium, Rostral migratory stream, skin of hip, skin of thigh, tibia, trabecular bone, vas deferens, visceral pleura. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 103

ATP7A → antimicrobial humoral response, apical plasma membrane, ATP binding, ATPase-coupled cation transmembrane transporter activity, basolateral plasma membrane, blood vessel development, blood vessel remodeling, brush border membrane, cartilage development, catecholamine metabolic process, cation transport, cell leading edge, cellular copper ion homeostasis, cellular response to amino acid stimulus, cellular response to antibiotic, cellular response to cadmium ion, cellular response to cobalt ion, cellular response to copper ion, cellular response to hypoxia, cellular response to iron ion

Bgee · 20

ATP7A → Achilles tendon, buccal mucosa cell, choroid plexus of fourth ventricle, corpus epididymis, efferent ductule, Epithelium of choroid plexus, external carotid artery, germinal epithelium, internal carotid artery, iris, left lung lobe, parietal pleura, retinal pigment epithelium, Rostral migratory stream, skin of hip, skin of thigh, tibia, trabecular bone, vas deferens, visceral pleura

RNA expression pattern · 20

related to Clinical significance · 14

ATP7A → American College, As, Copper, Cu, DNA, Genomics, Golgi, Many, Medical Genetics, Menkes, OHS, Other, Researchers, The

related to External links · 11

ATP7A → ATP7A-Related Copper Transport Disorders, ATP7A-Related Copper Transport DisordersGeneCardHuman, ATP7A-Related Distal Motor NeuropathyOMIM, GeneReviews/NCBI/NIH/UW, Includes, Medicine Medical Subject Headings, Menkes Disease, MeSH, National Library, Occipital Horn Syndrome, UCSC Genome Browser

related to Transport mechanism · 11

ATP7A → ATP, ATP-binding, Cu, DKTG, E1, E2, In, P-type ATPases, The, Then ATP7A, Within

related to Interactions · 9

ATP7A → Antioxidant, ATOX1, Cu, GLRX, Glutaredoxin-1, GMTCXXC, Golgi-network, GRX1, It

related to Function · 8

ATP7A → After Cu, Cu, Golgi, Here, If Cu, In, The, This

related to Structure · 8

ATP7A → An ATP-binding, ATP7B, C-termini, Cu, Eight, GMTCXXC, It, N-terminal

related to Gene · 5

ATP7A → At, Mutations/additions/deletions, The, The ATP7A, Xq21

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cu protein gene copper human transport transmembrane cell mutations function bp binding band tissues membrane chr motif disease chromosome also

ATP7A relationships Subject–Predicate–Object triples

TTTA extracted 236 structured relationships around ATP7A. Examples in this analysis include ATP7A → 7.2.2.8 → ↗ and ATP7A → Aliases → ATP7A, DSMAX, MK, MNK, SMAX3, ATPase copper transporting alpha. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
ATP7A	7.2.2.8	↗	1.00	infobox
ATP7A	Aliases	ATP7A, DSMAX, MK, MNK, SMAX3, ATPase copper transporting alpha	1.00	infobox
ATP7A	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AW0, 1KVI, 1KVJ, 1Q8L, 1S6O, 1S6U, 1Y3J, 1Y3K, 1YJR, 1YJT, 1YJU, 1YJV, 2G9O, 2GA7, 2K1R, 2KIJ, 2KMV, 2KMX,…	1.00	infobox
ATP7A	Band	Xq21.1	1.00	infobox
ATP7A	Band	X D\|X 47.36 cM	1.00	infobox
ATP7A	Bgee	buccal mucosa cell	1.00	infobox
ATP7A	Bgee	trabecular bone	1.00	infobox
ATP7A	Bgee	skin of thigh	1.00	infobox
ATP7A	Bgee	germinal epithelium	1.00	infobox
ATP7A	Bgee	corpus epididymis	1.00	infobox
ATP7A	Bgee	tibia	1.00	infobox
ATP7A	Bgee	Achilles tendon	1.00	infobox
ATP7A	Bgee	parietal pleura	1.00	infobox
ATP7A	Bgee	visceral pleura	1.00	infobox
ATP7A	Bgee	skin of hip	1.00	infobox
ATP7A	Bgee	Epithelium of choroid plexus	1.00	infobox
ATP7A	Bgee	Rostral migratory stream	1.00	infobox
ATP7A	Bgee	internal carotid artery	1.00	infobox
ATP7A	Bgee	choroid plexus of fourth ventricle	1.00	infobox
ATP7A	Bgee	external carotid artery	1.00	infobox
ATP7A	Bgee	retinal pigment epithelium	1.00	infobox
ATP7A	Bgee	vas deferens	1.00	infobox
ATP7A	Bgee	left lung lobe	1.00	infobox
ATP7A	Bgee	efferent ductule	1.00	infobox
ATP7A	Bgee	iris	1.00	infobox
ATP7A	BioGPS	n/a	1.00	infobox
ATP7A	Chr.	X chromosome (human)	1.00	infobox
ATP7A	Chr.	X chromosome (mouse)	1.00	infobox
ATP7A	Databases	NCBI: entry; OMA: entry	1.00	infobox
ATP7A	End	78,050,395 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ATP7A bring nearby vocabulary together. In this analysis, examples include Cu, Protein and Copper. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

ATP7A
- Cu
- Protein
- Copper
- Gene
- Disease
- Membrane
- Cell
- Human
- Mutations
- Transport
- Function
- Transmembrane
atp7a
- Cu
- Protein
- Copper
- Gene
- Disease
- Membrane
- Cell
- Human
- Mutations
- Transport
- Function
- Transmembrane
p-type atpase
- Acid
- Metal
- External
- Function
- Cell
- Transport
- Atpase
- Chromosome
- Expressed
- Location
- P-type
- Structure
atp hydrolysis
- P-type
- External
- Binding
- Cell
- Atpase
- Expressed
- Transmembrane
- Transport
- Acid
- Band
- Chromosome
- Golgi
transmembrane protein
- Motif
- Cell
- Expressed
- Activity
- Tissues
- Cu
- Transmembrane
- Transport
- Golgi
- Intestine
- Binding
- Human
aspartic acid
- P-type
- External
- Transport
- Atp
- Expressed
- Band
- Chromosome
- Golgi
- Location
- Metal
- Activity
- Bp
basolateral membrane
- Enzymes
- Transmembrane
- External
- Copper
- Acid
- Band
- Chromosome
- Location
- Metal
- P-type
- -binding
- Activity
antioxidant 1 copper chaperone
- Activity
- Gene
- Function
- Transport
- Location
- Disease
- Human
- Mutations
- External
- Chromosome
- Golgi
- Menkes

Connections between topic areas Semantic bridges

For ATP7A, one of the stronger structural bridges in this analysis connects ATP7A with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

ATP7A — Overview · splits 28 ⟂ 9

ATP7A — Structure · splits 30 ⟂ 7

ATP7A — Clinical significance · splits 32 ⟂ 5

ATP7A — Interactions · splits 33 ⟂ 4

ATP7A — Gene · splits 34 ⟂ 3

ATP7A — Conformational change · splits 34 ⟂ 3

ATP7A — Function · splits 34 ⟂ 3

Map overview Semantic statistics

ATP7A

Nodes37

Edges36

Triples236

Avg. degree1.95

Density0.054054

Components1

Source & methodology

TTTA analyzes the structure around ATP7A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure, Clinical significance & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ATP7A · EN edition · Analysis: TopicsToTalkAbout