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ADH5: Overview & Clinical significance

Alcohol dehydrogenase class-3 is an enzyme that in humans is encoded by the ADH5 gene.

Language: English [EN]
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ADH5 topic overview

The analysis highlights Overview and Clinical significance as prominent areas in the source structure around ADH5.

Related topics
25
Source areas
2
Connected nodes
27
Extracted relationships
93
Related term clusters
20
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 23 topics
Clinical significance · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

1.1.1.1
↗
1.1.1.284
↗
Aliases
ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide, BMFS7, AMEDS
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M6H, 1M6W, 1MA0, 1MC5, 1MP0, 1TEH, 2FZE, 2FZW, 3QJ5
Band
4q23 · 3|3 G3
Bgee
gastric mucosa · Descending thoracic aorta · stromal cell of endometrium · kidney tubule · corpus epididymis

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How ADH5 connects Entity context

The extracted context around ADH5 shows recurring relationship patterns in the source. For example, ADH5 → alcohol dehydrogenase (NAD+) activity, alcohol dehydrogenase activity, zinc-dependent, cytoplasm, cytosol, electron transfer activity, electron transport chain, ethanol oxidation, extracellular exosome, fatty acid binding, formaldehyde catabolic process, formaldehyde dehydrogenase activity, metal ion binding, mitochondrion, oxidoreductase activity, peptidyl-cysteine S-nitrosylation, positive regulation of blood pressure, protein homodimerization activity, respiratory system process, response to lipopolysaccharide, response to nitrosative stress Another extracted example is ADH5 → Achilles tendon, ascending aorta, atrioventricular valve, corpus epididymis, Descending thoracic aorta, endocardial cushion, gastric mucosa, Gonadal ridge, kidney tubule, left lobe of liver, medial ganglionic eminence, medullary collecting duct, olfactory epithelium, popliteal artery, primitive streak, stromal cell of endometrium, tibial arteries, ureter, vas deferens, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

ADH5

Top relations

Gene ontology · 24
ADH5 → alcohol dehydrogenase (NAD+) activity, alcohol dehydrogenase activity, zinc-dependent, cytoplasm, cytosol, electron transfer activity, electron transport chain, ethanol oxidation, extracellular exosome, fatty acid binding, formaldehyde catabolic process, formaldehyde dehydrogenase activity, metal ion binding, mitochondrion, oxidoreductase activity, peptidyl-cysteine S-nitrosylation, positive regulation of blood pressure, protein homodimerization activity, respiratory system process, response to lipopolysaccharide, response to nitrosative stress
Bgee · 20
ADH5 → Achilles tendon, ascending aorta, atrioventricular valve, corpus epididymis, Descending thoracic aorta, endocardial cushion, gastric mucosa, Gonadal ridge, kidney tubule, left lobe of liver, medial ganglionic eminence, medullary collecting duct, olfactory epithelium, popliteal artery, primitive streak, stromal cell of endometrium, tibial arteries, ureter, vas deferens, ventricular zone
RNA expression pattern · 20
ADH5 → Achilles tendon, ascending aorta, atrioventricular valve, corpus epididymis, Descending thoracic aorta, endocardial cushion, gastric mucosa, Gonadal ridge, kidney tubule, left lobe of liver, medial ganglionic eminence, medullary collecting duct, olfactory epithelium, popliteal artery, primitive streak, stromal cell of endometrium, tibial arteries, ureter, vas deferens, ventricular zone
related to Clinical significance · 3
ADH5 → ALDH2, AMED, Mutations
Band · 2
ADH5 → 3|3 G3, 4q23
Chr. · 2
ADH5 → Chromosome 3 (mouse), Chromosome 4 (human)
End · 2
ADH5 → 138,161,260 bp, 99,088,801 bp
1.1.1.1 · 1
ADH5 → ↗
1.1.1.284 · 1
ADH5 → ↗
Aliases · 1
ADH5 → ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide, BMFS7, AMEDS

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene alcohol dehydrogenase bp human chr formaldehyde band enzyme ethanol chromosome location class iii chi activity family alcohols oxidation glutathione

ADH5 relationships Subject–Predicate–Object triples

TTTA extracted 93 structured relationships around ADH5. Examples in this analysis include ADH5 → 1.1.1.1 → ↗ and ADH5 → Aliases → ADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide, BMFS7, AMEDS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ADH51.1.1.1↗1.00infobox
ADH51.1.1.284↗1.00infobox
ADH5AliasesADH5, ADH-3, ADHX, FALDH, FDH, GSH-FDH, GSNOR, HEL-S-60p, alcohol dehydrogenase 5 (class III), chi polypeptide, BMFS7, AMEDS1.00infobox
ADH5Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1M6H, 1M6W, 1MA0, 1MC5, 1MP0, 1TEH, 2FZE, 2FZW, 3QJ51.00infobox
ADH5Band4q231.00infobox
ADH5Band3|3 G31.00infobox
ADH5Bgeegastric mucosa1.00infobox
ADH5BgeeDescending thoracic aorta1.00infobox
ADH5Bgeestromal cell of endometrium1.00infobox
ADH5Bgeekidney tubule1.00infobox
ADH5Bgeecorpus epididymis1.00infobox
ADH5Bgeeascending aorta1.00infobox
ADH5BgeeAchilles tendon1.00infobox
ADH5Bgeepopliteal artery1.00infobox
ADH5Bgeetibial arteries1.00infobox
ADH5Bgeeventricular zone1.00infobox
ADH5Bgeeprimitive streak1.00infobox
ADH5Bgeeleft lobe of liver1.00infobox
ADH5BgeeGonadal ridge1.00infobox
ADH5Bgeeendocardial cushion1.00infobox
ADH5Bgeemedullary collecting duct1.00infobox
ADH5Bgeeureter1.00infobox
ADH5Bgeemedial ganglionic eminence1.00infobox
ADH5Bgeevas deferens1.00infobox
ADH5Bgeeolfactory epithelium1.00infobox
ADH5Bgeeatrioventricular valve1.00infobox
ADH5BioGPSn/a1.00infobox
ADH5Chr.Chromosome 4 (human)1.00infobox
ADH5Chr.Chromosome 3 (mouse)1.00infobox
ADH5DatabasesNCBI: entry; OMA: entry1.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around ADH5 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Alcohol. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ADH5
    • Gene
    • Location
    • Alcohol
    • Dehydrogenase
    • Human
    • Search
    • Ucsc
    • Activity
    • Enzyme
    • Chromosome
    • Bp
    • Chr
  • adh5
    • Gene
    • Location
    • Alcohol
    • Dehydrogenase
    • Human
    • Search
    • Ucsc
    • Activity
    • Enzyme
    • Chromosome
    • Bp
    • Chr
  • formaldehyde dehydrogenase
    • Chi
    • Class
    • Iii
    • Gene
    • Cellular
    • Component
    • Glutathione
    • Oxidation
    • Activity
    • Ethanol
    • Search
    • Enzyme
  • alcohol dehydrogenase
    • Dehydrogenase
    • Chi
    • Class
    • Iii
    • Gene
    • Adh5
    • Search
    • Activity
    • Enzyme
    • Chromosome
    • Formaldehyde
    • Location
  • alcohol
    • Dehydrogenase
    • Chi
    • Class
    • Iii
    • Gene
    • Adh5
    • Search
    • Activity
    • Enzyme
    • Chromosome
    • Formaldehyde
    • Location
  • ethanol
    • Alcohols
    • Glutathione
    • Oxidation
    • Activity
    • Formaldehyde
    • Adduct
    • Hydroxysteroids
    • Metabolize
    • Retinol
    • Substrates
    • Cellular
    • Component
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • End
    • Mouse
    • Search
    • Ucsc
    • Activity
    • Chi
    • Class
  • cellular metabolism
    • Component
    • Formaldehyde
    • End
    • Glutathione
    • Mouse
    • Oxidation
    • Search
    • Ucsc
    • Enzyme
    • Ethanol
    • Band
    • Chromosome

Connections between topic areas Semantic bridges

For ADH5, one of the stronger structural bridges in this analysis connects ADH5 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ADH5 — Overview · splits 4 ⟂ 24
ADH5 — Clinical significance · splits 25 ⟂ 3

Map overview Semantic statistics

ADH5

Nodes28
Edges27
Triples93
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around ADH5 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ADH5 · EN edition · Analysis: TopicsToTalkAbout

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