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ADAMTS2: Function, Gene & Clinical significance

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme that in humans is encoded by the ADAMTS2 gene.

Language: English [EN]
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ADAMTS2 topic overview

The analysis highlights Function, Gene and Clinical significance as prominent areas in the source structure around ADAMTS2.

Related topics
10
Source areas
4
Connected nodes
14
Extracted relationships
89
Concept neighborhoods
10
Bridge connections
14

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 4 topics
Clinical significance · 2 topics
Gene · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.24.14
Aliases
ADAMTS2, ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, ADAM metallopeptidase with thrombospondin type 1 motif 2, EDSDERMS
Band
11|11 B1.3
Bgee
stromal cell of endometrium · subcutaneous adipose tissue · right lung · right coronary artery · spleen
BioGPS
n/a
Chr.
Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How ADAMTS2 connects Entity context

The extracted context around ADAMTS2 shows recurring relationship patterns in the source. For example, ADAMTS2 → ankle, aortic valve, ascending aorta, body of femur, cervix, decidua, gastric mucosa, gastrula, left coronary artery, left uterine tube, myometrium, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, umbilical cord, upper lobe of left lung, vas deferens Another extracted example is ADAMTS2 → collagen catabolic process, collagen fibril organization, collagen-containing extracellular matrix, extracellular matrix, extracellular region, hydrolase activity, lung development, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein processing, proteolysis, skin development, spermatogenesis, zinc ion binding. Use these groups to spot repeated connection types before inspecting the individual relationships.

ADAMTS2

Top relations

Bgee · 20
ADAMTS2 → ankle, aortic valve, ascending aorta, body of femur, cervix, decidua, gastric mucosa, gastrula, left coronary artery, left uterine tube, myometrium, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, umbilical cord, upper lobe of left lung, vas deferens
RNA expression pattern · 20
ADAMTS2 → ankle, aortic valve, ascending aorta, body of femur, cervix, decidua, gastric mucosa, gastrula, left coronary artery, left uterine tube, myometrium, right coronary artery, right lung, spleen, stroma of bone marrow, stromal cell of endometrium, subcutaneous adipose tissue, umbilical cord, upper lobe of left lung, vas deferens
Gene ontology · 16
ADAMTS2 → collagen catabolic process, collagen fibril organization, collagen-containing extracellular matrix, extracellular matrix, extracellular region, hydrolase activity, lung development, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, protein processing, proteolysis, skin development, spermatogenesis, zinc ion binding
related to Clinical significance · 7
ADAMTS2 → As, Cross-links, Danlos, Ehlers, Procollagen, Several, These
related to External links · 4
ADAMTS2 → Deprecated, GeneCardThe MEROPS, M12, UCSC Genome Browser
related to Function · 3
ADAMTS2 → Procollagens, Specifically, This
3.4.24.14 · 1
ADAMTS2 → ↗
Aliases · 1
ADAMTS2 → ADAMTS2, ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, ADAM metallopeptidase with thrombospondin type 1 motif 2, EDSDERMS
Band · 1
ADAMTS2 → 11|11 B1.3
BioGPS · 1
ADAMTS2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene enzyme procollagen bp also collagen chr function location chromosome mutations mouse band end thrombospondin adam-ts2 pc i-np external fibrils

ADAMTS2 relationships Subject–Predicate–Object triples

TTTA extracted 89 structured relationships around ADAMTS2. Examples in this analysis include ADAMTS2 → 3.4.24.14 → ↗ and ADAMTS2 → Aliases → ADAMTS2, ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, ADAM metallopeptidase with thrombospondin type 1 motif 2, EDSDERMS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ADAMTS23.4.24.141.00infobox
ADAMTS2AliasesADAMTS2, ADAM-TS2, ADAMTS-2, ADAMTS-3, NPI, PC I-NP, PCI-NP, PCINP, PCPNI, PNPI, ADAM metallopeptidase with thrombospondin type 1 motif 2, EDSDERMS1.00infobox
ADAMTS2Band11|11 B1.31.00infobox
ADAMTS2Bgeestromal cell of endometrium1.00infobox
ADAMTS2Bgeesubcutaneous adipose tissue1.00infobox
ADAMTS2Bgeeright lung1.00infobox
ADAMTS2Bgeeright coronary artery1.00infobox
ADAMTS2Bgeespleen1.00infobox
ADAMTS2Bgeeleft coronary artery1.00infobox
ADAMTS2Bgeeupper lobe of left lung1.00infobox
ADAMTS2Bgeegastric mucosa1.00infobox
ADAMTS2Bgeemyometrium1.00infobox
ADAMTS2Bgeeleft uterine tube1.00infobox
ADAMTS2Bgeeascending aorta1.00infobox
ADAMTS2Bgeeaortic valve1.00infobox
ADAMTS2Bgeedecidua1.00infobox
ADAMTS2Bgeegastrula1.00infobox
ADAMTS2Bgeeumbilical cord1.00infobox
ADAMTS2Bgeestroma of bone marrow1.00infobox
ADAMTS2Bgeebody of femur1.00infobox
ADAMTS2Bgeeankle1.00infobox
ADAMTS2Bgeecervix1.00infobox
ADAMTS2Bgeevas deferens1.00infobox
ADAMTS2BioGPSn/a1.00infobox
ADAMTS2Chr.Chromosome 11 (mouse)1.00infobox
ADAMTS2DatabasesNCBI: entry1.00infobox
ADAMTS2End50,698,400 bp1.00infobox
ADAMTS2Ensembln/a1.00infobox
ADAMTS2Entrez95091.00infobox
ADAMTS2Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc3.4.24.14↗↗↗↗1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around ADAMTS2 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Mutations. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ADAMTS2
    • Gene
    • Location
    • Mutations
    • Enzyme
    • Activity
    • B1
    • Chromosome
    • Human
    • I-np
    • Metallopeptidase
    • Mouse
    • Pc
  • adamts2
    • Gene
    • Location
    • Mutations
    • Enzyme
    • Activity
    • B1
    • Chromosome
    • Human
    • I-np
    • Metallopeptidase
    • Mouse
    • Pc
  • gene
    • Location
    • Mutations
    • Activity
    • B1
    • Chromosome
    • Human
    • I-np
    • Metallopeptidase
    • Mouse
    • Pc
    • Syndrome
    • Thrombospondin
  • function
    • Activity
    • B1
    • Chromosome
    • Metallopeptidase
    • Mouse
    • Bp
    • Chr
    • Location
    • Collagen
    • External
    • Band
    • Body
  • chromosome 5
    • B1
    • Metallopeptidase
    • Mouse
    • Bp
    • Function
    • Location
    • External
    • Band
    • Body
    • End
    • Human
    • I-np
  • enzyme
    • Procollagen
    • I-np
    • Pc
    • Thrombospondin
    • Gene
    • External
    • Metalloproteinase
    • Motifs
    • Activity
    • B1
    • Chromosome
    • End
  • procollagen
    • End
    • Pc
    • Processing
    • Proteins
    • Several
    • Thrombospondin
  • ehlers–danlos syndrome
    • Mutations
    • Several
    • Type

Connections between topic areas Semantic bridges

For ADAMTS2, one of the stronger structural bridges in this analysis connects ADAMTS2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ADAMTS2Function · splits 10 ⟂ 5
ADAMTS2Overview · splits 12 ⟂ 3
ADAMTS2Gene · splits 12 ⟂ 3
ADAMTS2Clinical significance · splits 12 ⟂ 3

Map overview Semantic statistics

ADAMTS2

Nodes15
Edges14
Triples89
Avg. degree1.87
Density0.133333
Components1

Source & methodology

TTTA analyzes the structure around ADAMTS2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Gene & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ADAMTS2 · EN edition · Analysis: TopicsToTalkAbout

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