Activity-based proteomics

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Activity-based proteomics. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Probe design

Covalently Nucleophile Epoxides Vinyl sulfones Photoreactive

28 related topics

Historical development

Penicillin Ben Cravatt Scripps Research Institute Stanford University Leiden University

10 related topics

Detection methods

Tandem mass spectrometry Stable Isotope Labeling by Amino acids in Cell culture Tandem mass tagging Isobaric mass tags

4 related topics

Overview

Chemoproteomic Active sites

2 related topics

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Chemoproteomic Chemoproteomics
Active sites Active site

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes49

Edges48

Triples20

Avg. degree1.96

Density0.040816

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

enzyme abpp active enzymes activity protein probes abps used proteins functional probe proteomics profiling activity-based mass spectrometry target enabling inactive

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
the serine hydrolases	instance of	produce radical intermediates that form covalent crosslinks with nearby residues in the enzyme active site.With classes of enzymes	0.80	text
metalloproteases that often interact with endogenous inhibitors or that exist as inactive zymogens	instance of	produce radical intermediates that form covalent crosslinks with nearby residues in the enzyme active site.With classes of enzymes	0.80	text
ABPP offers a valuable advantage over traditional techniques that rely on abundance rather than activity	instance of	produce radical intermediates that form covalent crosslinks with nearby residues in the enzyme active site.With classes of enzymes	0.80	text
masked warheads	instance of	Strategies	0.80	text
which become activated only in the presence of a target enzyme	instance of	Strategies	0.80	text
have been developed to improve specificity.LinkerBetween the reactive group	instance of	Strategies	0.80	text
the tag	instance of	Strategies	0.80	text
ABPs often include a linker / spacer / biorecognition element	instance of	Strategies	0.80	text
which can tune probe solubility	instance of	Strategies	0.80	text
steric accessibility	instance of	Strategies	0.80	text
and substrate mimicry	instance of	Strategies	0.80	text
biotin	instance of	or an affinity label	0.80	text

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3

Research this topic

Explore this topic

Probe design

Historical development

Detection methods

Overview

Key facts & relationships

Topics to explore

Overview

Historical development

Probe design

Detection methods

Advanced semantic analysis

Map overview Semantic statistics