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ABHD12

alpha/beta-Hydrolase domain containing 12 (ABHD12) is a serine hydrolase encoded by the ABHD12 gene that participates in the breakdown of the endocannabinoid neurotransmitter 2-arachidonylglycerol (2-AG) in the central nervous system. It is responsible for about 9% of brain 2-AG hydrolysis. Together, ABHD12 along with two other enzymes, monoacylglycerol…

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3.1.1.23
↗
Aliases
ABHD12, ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2, abhydrolase domain containing 12, habhydrolase domain containing 12, lysophospholipase
Band
20p11.21 · 2|2 G3
Bgee
C1 segment · prefrontal cortex · body of pancreas · left lobe of thyroid gland · right lobe of thyroid gland
BioGPS
n/a
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

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Protein structure

Function

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Mutations

Inhibitors

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Map overview Semantic statistics

ABHD12

Nodes91
Edges90
Triples110
Avg. degree1.98
Density0.021978
Components1

How this topic connects Entity context

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ABHD12

Top relations

Bgee · 20
ABHD12 → anterior cingulate cortex, body of pancreas, Brodmann area 9, C1 segment, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, lateral hypothalamus, left lobe of thyroid gland, nucleus accumbens, pontine nuclei, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right lobe of thyroid gland, seminal vesicula, superior frontal gyrus, transitional epithelium of urinary bladder
RNA expression pattern · 20
ABHD12 → anterior cingulate cortex, body of pancreas, Brodmann area 9, C1 segment, cerebellar cortex, cingulate gyrus, dentate gyrus of hippocampal formation granule cell, dorsomedial hypothalamic nucleus, lateral hypothalamus, left lobe of thyroid gland, nucleus accumbens, pontine nuclei, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, right lobe of thyroid gland, seminal vesicula, superior frontal gyrus, transitional epithelium of urinary bladder
Gene ontology · 17
ABHD12 → acylglycerol catabolic process, acylglycerol lipase activity, adult walking behavior, AMPA glutamate receptor complex, cytoplasm, dendrite cytoplasm, glycerophospholipid catabolic process, hydrolase activity, integral component of membrane, lysophospholipase activity, membrane, monoacylglycerol catabolic process, palmitoyl-(protein) hydrolase activity, phosphatidylserine catabolic process, plasma membrane, protein depalmitoylation, response to auditory stimulus
related to Function · 8
ABHD12 → ABHD6, AG, AG-CB2R, Along, Based, Endocannabinoids, MAGL, Murine
related to Inhibitors · 5
ABHD12 → Inhibitors, MAFP, Orlistat, Selective, THL
related to Interactions · 5
ABHD12 → ABHD16A, AG, Elevated, In, PHARC
related to Mutations · 4
ABHD12 → Currently, Mutations, Null, PHARC
related to history · 3
ABHD12 → Identification, In, PHARC
related to Models · 3
ABHD12 → Based, PHARC, The
Band · 2
ABHD12 → 20p11.21, 2|2 G3

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Important terminology

2-ag pharc human brain hydrolase bp lipase chr band hydrolysis gene mutations also monoacylglycerol chromosome 20 mouse domain inhibitors lysophospholipase

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ABHD123.1.1.23↗1.00infobox
ABHD12AliasesABHD12, ABHD12A, BEM46L2, C20orf22, PHARC, dJ965G21.2, abhydrolase domain containing 12, habhydrolase domain containing 12, lysophospholipase1.00infobox
ABHD12Band20p11.211.00infobox
ABHD12Band2|2 G31.00infobox
ABHD12BgeeC1 segment1.00infobox
ABHD12Bgeeprefrontal cortex1.00infobox
ABHD12Bgeebody of pancreas1.00infobox
ABHD12Bgeeleft lobe of thyroid gland1.00infobox
ABHD12Bgeeright lobe of thyroid gland1.00infobox
ABHD12Bgeeright frontal lobe1.00infobox
ABHD12Bgeecingulate gyrus1.00infobox
ABHD12Bgeeanterior cingulate cortex1.00infobox
ABHD12Bgeenucleus accumbens1.00infobox
ABHD12BgeeBrodmann area 91.00infobox
ABHD12Bgeetransitional epithelium of urinary bladder1.00infobox
ABHD12Bgeesuperior frontal gyrus1.00infobox
ABHD12Bgeeprimary visual cortex1.00infobox
ABHD12Bgeeprimary motor cortex1.00infobox
ABHD12Bgeeseminal vesicula1.00infobox
ABHD12Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
ABHD12Bgeelateral hypothalamus1.00infobox
ABHD12Bgeedorsomedial hypothalamic nucleus1.00infobox
ABHD12Bgeepontine nuclei1.00infobox
ABHD12Bgeecerebellar cortex1.00infobox
ABHD12BioGPSn/a1.00infobox
ABHD12Chr.Chromosome 20 (human)1.00infobox
ABHD12Chr.Chromosome 2 (mouse)1.00infobox
ABHD12DatabasesNCBI: entry; OMA: entry1.00infobox
ABHD12End25,390,835 bp1.00infobox
ABHD12End150,746,661 bp1.00infobox

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