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Alanyl—tRNA synthetase 1 (AARS1) is an enzyme that is encoded by the AARS1 gene in humans and is a member of the aminoacyl-tRNA synthetases (ARSs) family of enzymes.
The analysis highlights Clinical significance and Overview as prominent areas in the source structure around AARS1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
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The extracted context around AARS1 shows recurring relationship patterns in the source. For example, AARS1 → alanine-tRNA ligase activity, alanyl-tRNA aminoacylation, amino acid binding, aminoacyl-tRNA editing activity, aminoacyl-tRNA ligase activity, aminoacyl-tRNA metabolism involved in translational fidelity, ATP binding, cerebellar Purkinje cell layer development, cytoplasm, cytosol, extracellular exosome, ligase activity, membrane, metal ion binding, mitochondrion, negative regulation of neuron apoptotic process, neuromuscular process, neuromuscular process controlling balance, nucleic acid binding, nucleotide binding Another extracted example is AARS1 → anterior horn of spinal cord, beta cell, Brodmann area 10, Brodmann area 9, calvaria, cerebellar vermis, cingulate gyrus, crypt of lieberkuhn of small intestine, endothelial cell of lymphatic vessel, facial motor nucleus, frontal pole, lacrimal gland, left lobe of liver, middle frontal gyrus, paraflocculus of cerebellum, primitive streak, right frontal lobe, somite, stroma of bone marrow, stromal cell of endometrium. Use these groups to spot repeated connection types before inspecting the individual relationships.
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bp gene chr human 16 band trna chromosome mutations synthetase aminoacyl-trna location enzyme trichothiodystrophy mouse enzymes amino protein cmt2 genes
TTTA extracted 112 structured relationships around AARS1. Examples in this analysis include AARS1 → 6.1.1.7 → ↗ and AARS1 → Aliases → AARS1, CMT2N, EIEE29, alanyl-tRNA synthetase, AARS, alanyl-tRNA synthetase 1, DEE29, TTD8, HDLS2. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| AARS1 | 6.1.1.7 | ↗ | 1.00 | infobox |
| AARS1 | Aliases | AARS1, CMT2N, EIEE29, alanyl-tRNA synthetase, AARS, alanyl-tRNA synthetase 1, DEE29, TTD8, HDLS2 | 1.00 | infobox |
| AARS1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4XEO, 4XEM | 1.00 | infobox |
| AARS1 | Band | 16q22.1 | 1.00 | infobox |
| AARS1 | Band | 8|8 E1 | 1.00 | infobox |
| AARS1 | Bgee | beta cell | 1.00 | infobox |
| AARS1 | Bgee | frontal pole | 1.00 | infobox |
| AARS1 | Bgee | Brodmann area 10 | 1.00 | infobox |
| AARS1 | Bgee | right frontal lobe | 1.00 | infobox |
| AARS1 | Bgee | middle frontal gyrus | 1.00 | infobox |
| AARS1 | Bgee | paraflocculus of cerebellum | 1.00 | infobox |
| AARS1 | Bgee | Brodmann area 9 | 1.00 | infobox |
| AARS1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| AARS1 | Bgee | cingulate gyrus | 1.00 | infobox |
| AARS1 | Bgee | cerebellar vermis | 1.00 | infobox |
| AARS1 | Bgee | calvaria | 1.00 | infobox |
| AARS1 | Bgee | left lobe of liver | 1.00 | infobox |
| AARS1 | Bgee | facial motor nucleus | 1.00 | infobox |
| AARS1 | Bgee | lacrimal gland | 1.00 | infobox |
| AARS1 | Bgee | stroma of bone marrow | 1.00 | infobox |
| AARS1 | Bgee | anterior horn of spinal cord | 1.00 | infobox |
| AARS1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| AARS1 | Bgee | somite | 1.00 | infobox |
| AARS1 | Bgee | primitive streak | 1.00 | infobox |
| AARS1 | Bgee | crypt of lieberkuhn of small intestine | 1.00 | infobox |
| AARS1 | BioGPS | n/a | 1.00 | infobox |
| AARS1 | Chr. | Chromosome 16 (human) | 1.00 | infobox |
| AARS1 | Chr. | Chromosome 8 (mouse) | 1.00 | infobox |
| AARS1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| AARS1 | End | 70,289,707 bp | 1.00 | infobox |
The concept neighborhoods around AARS1 bring nearby vocabulary together. In this analysis, examples include Mutations, Gene and Aminoacyl-trna. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For AARS1, one of the stronger structural bridges in this analysis connects AARS1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around AARS1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — AARS1 · EN edition · Analysis: TopicsToTalkAbout
