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Proteinkináza R

Proteinkináza R (PKR, proteinkináza aktivovaná dvouřetězcovou RNA (dsRNA)) je enzym ze skupiny serin/threonin kináz, který fosforyluje eukaryotický iniciační faktor eIF-2. Po této fosforylaci dochází k zastavení syntézy bílkovin v buňce, tedy jinými slovy k inhibici translace. To je důležité při obraně proti napadení buňky viry – PKR je aktivována po…

Struktura, Funkce & Overview

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Struktura

Funkce

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Proteinkináza R

Nodes37
Edges36
Triples28
Avg. degree1.95
Density0.054054
Components1

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Proteinkináza R

Top relations

related to Struktura · 18
Proteinkináza R → C-koncovou, Dané, IFN-stimulated, ISRE, Kvůli, N-terminální, Navazání, Navázání, PKR, Promotor, PRR, RNA, RNA-vazebného, Serin, Thr-446, Thr-451, Threonin, Tyrosin
related to Funkce · 10
Proteinkináza R → Daná, Daný, HSP, Iniciace, Navázáni, PDGF, PKR, Platelet Derived Growth Faktor, Proteinkináza, Serin

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Important terminology

pkr rna eif-2 obsahuje serin translace proteinkináza dvouřetězcovou buňky threonin fosforylaci genu interferonů aminokyselin vede skupiny faktor syntézy inhibici aktivována

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Proteinkináza Rrelated to FunkceProteinkináza0.60section
Proteinkináza Rrelated to FunkcePKR0.60section
Proteinkináza Rrelated to FunkceHSP0.60section
Proteinkináza Rrelated to FunkcePDGF0.60section
Proteinkináza Rrelated to FunkcePlatelet Derived Growth Faktor0.60section
Proteinkináza Rrelated to FunkceDaná0.60section
Proteinkináza Rrelated to FunkceIniciace0.60section
Proteinkináza Rrelated to FunkceNavázáni0.60section
Proteinkináza Rrelated to FunkceSerin0.60section
Proteinkináza Rrelated to FunkceDaný0.60section
Proteinkináza Rrelated to StrukturaPKR0.60section
Proteinkináza Rrelated to StrukturaN-terminální0.60section

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